Medicinal composition for treating dysmenorrhea and preparation process thereof
A composition and drug technology, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problem of synergistic dysmenorrhea effective proportioning relationship has not been reported, and achieve good analgesic effect, wide range, concentrated effective ingredients. Effect
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experiment example 1
[0030] Experimental example 1 Analgesia experiment
[0031] 1. Effect on diethylstilbestrol and oxytocin-induced uterine cramps in mice
[0032] Diethylstilbestrol and oxytocin induced uterine cramps in female mice ♀ 60 mice were divided into 6 groups. Angelica polysaccharide: Corydalis tetrahydropalmatine total alkali is 4:1 (sample 1), 1:1 (sample 2), 1:4 (sample 3) of the composition of the present invention in different ratios, and the composition is irrigated at 120mg (total amount of active ingredients) / kg The stomach and the control group consisted of the same amount of angelica polysaccharides and total alkaloids of Corydalis, and the comparison experiment was carried out respectively, and the comparison between the groups was carried out by F test. The experimental results are shown in Table 1. One hour before the experiment, the total alkaloids of corydalis, angelica polysaccharide, and the drug of the present invention were given by intragastric administration, and the ...
experiment example 2
[0046] Experimental example 2 Effect on spontaneous activity of isolated uterus in ♀ mice
[0047]The experimental samples were the composition of the present invention in different ratios of Angelica sinensis polysaccharide: Corydalis total alkali at 4:1 (Sample 1), 1:1 (Sample 2), and 1:4 (Sample 3). Healthy non-pregnant mice, weighing 20-24g, used 2mg / kg SC diethylstilbestrol injection for 2 days before the experiment to improve the sensitivity of the uterus to the drug. During the experiment, the mice were put to death by dissection of their necks, and the uterus was quickly dissected, and immediately placed in the mixed gas (95% O 2 +5% CO 2 )% saturated Rockwell solution, carefully remove the connective tissue and fat tissue around the uterus to make a uterine specimen about 1cm in length. Fix one end of the specimen on the hook of the specimen plate and place it in a bath containing 20ml Rockwell solution. , The other end is connected to the tension transducer, the water ba...
Embodiment 1
[0052] Example 1: Preparation of capsules
[0053] Preparation of angelica polysaccharides: Angelica was extracted with 8 parts by weight of distilled water at reflux for 3 times, 4 hours each time. After the 3 times of extracts were combined, the extracts were combined and concentrated by distillation under reduced pressure. After the concentrate was pre-cooled, 3 times by volume of ethanol was added and stirred. After standing, the precipitate is collected by a high-speed refrigerated centrifuge to obtain the crude polysaccharide. The crude polysaccharide is dissolved in distilled water, dialyzed against distilled water at 4°C for 3 days, centrifuged to remove the precipitate, and the supernatant is freeze-dried to obtain.
[0054] The preparation of total alkali of Corydalis: Take Corydalis powder and put it in an extractor, moisten it with concentrated ammonia water, extract 6 times the volume of chloroform for 3 hours, filter, and evaporate the filtrate to dryness in a water ...
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