Dexibuprofen effervescent tablet and preparation method thereof

A technology of disintegrants and raw materials, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems that it is difficult to make soluble liquid dosage forms, difficult to prepare insoluble drugs, etc. problems, to achieve the effect of convenient administration, rapid onset of action and high bioavailability

Inactive Publication Date: 2007-11-28
汪洪湖
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the shortcomings of the oral preparations of dexibuprofen in the prior art, which are not easy to make soluble liquid dosage forms in water and difficult to prepare effervescent tablets. The effervescent tablet of Dexibuprofen and the preparation method thereof can make the effervescent tablet containing Dexibuprofen rapidly react with water to form a transparent and delicious solution, and has the advantages of convenient taking, high bioavailability and rapid onset of effect; Compared with ordinary liquid preparations, it also has the advantage of being more convenient to carry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: Dexibuprofen 200

[0029] Arginine 385

[0030] Sodium bicarbonate 700

[0031] Sodium Bitartrate 800

[0032] Lactose 785

[0033] Polyethylene glycol PEG 300

[0034] Appropriate amount of lubricant

[0035] Appropriate amount of stevioside and spices

[0036] Proper amount of ethanol or water

[0037] Process: crushing, mixing, granulating and tableting the above-mentioned raw and auxiliary materials to obtain the effervescent tablets of D-ibuprofen.

Embodiment 2

[0039] Prescription: Dexibuprofen 200

[0040] Arginine hydrochloride 385

[0041] Sodium bicarbonate 700

[0042] Sodium Bitartrate 1000

[0043] Sucrose 785

[0044] Polyvinylpyrrolidone PVP 200

[0045] Appropriate amount of lubricant

[0046] Appropriate amount of stevioside and spices

[0047] Proper amount of ethanol or water

[0048] Process: crushing, mixing, granulating and tableting the above-mentioned raw and auxiliary materials to obtain the effervescent tablets of D-ibuprofen.

Embodiment 3

[0050] Prescription: Dexibuprofen 200

[0051] Lysine 385

[0052] Sodium bicarbonate 400

[0053] Sodium Bitartrate 600

[0054] Mixture of lactose and sucrose 675

[0055] Polyvinylpyrrolidone PVP 200

[0056] Appropriate amount of lubricant

[0057] Appropriate amount of stevioside and spices

[0058] Proper amount of ethanol or water

[0059] Process: crushing, mixing, granulating and tableting the above-mentioned raw and auxiliary materials to obtain the effervescent tablets of D-ibuprofen.

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PUM

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Abstract

The present invention provides one kind of effervescent dextro brufen tablet and its preparation process, and features that the effervescent dextro brufen tablet contains dextro brufen 1 weight portions, alkaline cosolvent 0-100 weight portions, acid disintegrant 1-8 weight portions, alkaline disintegrant 2-15 weight portions, stuffing 0-15 weight portions, adhesive 0.1-12 weight portions, corrective 0.01-0.5 weight portion, and lubricant 0.1-2 weight portions. Its preparation process includes the steps of mixing, pelletizing and tabletting. The effervescent dextro brufen tablet is superior to traditional orally taken dextro brufen preparation, can dissolve in water to form tasty solution, and has easy taking, high bioavailability, fast acting and other advantages.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to an effervescent tablet containing dexibuprofen and a preparation method thereof. Background technique: [0002] Ibuprofen, namely 2-(4-isobutylphenyl)propionic acid, is a non-steroidal anti-inflammatory drug (NSAIDs) and is the first ibuprofen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic drug ladder [2], which is recorded in domestic and foreign pharmacopoeias and is one of the basic drugs in my country. Due to the stereoselectivity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/46A61K31/192A61K47/16A61P29/00
Inventor 汪洪湖
Owner 汪洪湖
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