Dexibuprofen effervescent tablet and preparation method thereof

Abstract

The present invention provides one kind of effervescent dextro brufen tablet and its preparation process, and features that the effervescent dextro brufen tablet contains dextro brufen 1 weight portions, alkaline cosolvent 0-100 weight portions, acid disintegrant 1-8 weight portions, alkaline disintegrant 2-15 weight portions, stuffing 0-15 weight portions, adhesive 0.1-12 weight portions, corrective 0.01-0.5 weight portion, and lubricant 0.1-2 weight portions. Its preparation process includes the steps of mixing, pelletizing and tabletting. The effervescent dextro brufen tablet is superior to traditional orally taken dextro brufen preparation, can dissolve in water to form tasty solution, and has easy taking, high bioavailability, fast acting and other advantages.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to an effervescent tablet containing dexibuprofen and a preparation method thereof. Background technique: [0002] Ibuprofen, namely 2-(4-isobutylphenyl)propionic acid, is a non-steroidal anti-inflammatory drug (NSAIDs) and is the first ibuprofen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs among NSAIDs. Pharmacological action shows its anti-inflammatory, analgesic and antipyretic effects. Clinically used for various acute and chronic arthritis, soft tissue rheumatism, tenosynovitis, sports injuries and headaches, myalgia, dysmenorrhea, pain after tooth extraction, and cancer pain. The drug is recommended as the first step drug in the analgesic drug ladder [2], which is recorded in domestic and foreign pharmacopoeias and is one of the basic drugs in my country. Due to the stereoselectivity ...

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the shortcomings of the oral preparations of dexibuprofen in the prior art, which are not easy to make soluble liquid dosage forms in water and difficult to prepare effervescent tablets. The effervescent tablet of Dexibuprofen and the preparation method thereof can make the effervescent tablet containing Dexibuprofen rapidly react with water to form a transparent and delicious solution, and has the advantages of convenient taking, high bioavailability and rapid onset of effect; Compared with ordinary liquid preparations, it also has the advantage of being more convenient to carry