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Method for preparing Notoginsen triterpenes

A technology of Panax notoginseng saponins and Panax notoginseng, which is applied in the field of preparation of Panax notoginseng saponins, can solve the problems of low purity of the extract, large loss of active ingredients of Panax notoginseng, cumbersome process, etc., and achieve easy industrialized large-scale production and extraction The effect of high separation efficiency and high physiological activity

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used methods for extracting notoginseng saponins from Panax notoginseng include alcohol extraction, alcohol extraction-resin method, water extraction alcohol extraction-resin method, etc., but the obtained extract (extract) is not high in purity, and the process is relatively cumbersome. , the loss of active ingredients of notoginseng is relatively large, therefore, it is of great significance to study the extraction and separation method of more effective and high-purity notoginseng saponins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take notoginseng medicinal materials (roots, stems), crush them, add water to boil and extract three times and control the pH, the first time is 6 times the amount of medicinal materials and 0.7% Na2CO3, the second time is 4 times the amount of medicinal materials and 0.3% Na2CO3 % Na2CO3 of the amount of medicinal material, the third time is 4 times the amount of water of the medicinal material; side countercurrent circulation extraction, after boiling, keep for 1.5, 1, 1 hour respectively; the medicinal liquid is combined and cooled to room temperature, filtered, and the filtrate has treated macropores Type weakly basic anion D392 exchange column (Nankai University Chemical Plant), rinse with 2% NaOH solution of 2 times the volume of the resin bed, discard the rinse solution; then rinse with pure water 3 times, discard the water rinse solution; use 7 times the volume of the resin bed Elute with 70% ethanol by bed volume, collect the eluate, concentrate to a thick paste...

Embodiment 2

[0017] Take Panax notoginseng leaves, crush them, add water and ultrasonically extract four times and control the pH, the first time is 5 times the amount of water and 0.9% of the amount of NaHCO3, and the second time is 4 times the amount of water and 0.5% of the amount of herbs NaHCO3, the third and fourth times are 3 times the amount of water of the medicinal material; the medicinal liquid is combined and cooled to room temperature, filtered, and the macroporous weakly basic anion D380 exchange column (Nankai University Chemical Plant) that has been processed on the medicinal liquid filtrate ), rinsed with 2.5% NaOH solution of 1.5 times the volume of the resin bed, and discarded the rinse solution; rinsed with 4 times of pure water, discarded the water rinse solution; eluted with 65% ethanol of 8 times the volume of the resin bed, and collected the eluate , concentrated to a thick paste (relative density at 50° C. is 1.28 to 1.33), and dried with a dynamic belt drying devic...

Embodiment 3

[0019] Get the Radix Notoginseng medical material (root, stem), pulverize, add 50% ethanol backflow extraction three times and control pH, the Na2CO3 of 5 times of 50% ethanol amount and 1% medicinal material amount for the first time, the second time is medicinal material amount 4 times the amount of 50% ethanol and 0.5% Na2CO3 of the amount of medicinal materials, the third time is 4 times the amount of 50% ethanol of the medicinal materials; side countercurrent circulation reflux extraction, after the reflux starts, keep 1.5, 1, 1 hour respectively; liquid filtration And combine the filtrates, after the filtrates are concentrated under reduced pressure at 70°C until there is no alcohol smell, the concentrated solution is diluted with water to a ratio of medicinal material to liquid of 1:1.5, filtered, and the filtrate has been treated on the macroporous strong basic anion D201 exchange column ( Chemical Plant of Nankai University), rinse with 2% NaOH solution of 2 times the ...

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PUM

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Abstract

The invention discloses a method for preparing notoginsen triterpenes. It comprises following steps: (1) collecting notoginseng roots or leaves, feeding them into disslovant, moderating to basic with solution, extracting and getting extract; (2) feeding extract into large- porous basic anion exchange column, washing with basic solution and pure water, getting rid of washing liquid, washing with water- containing ethanol, condensing washing liquid, and getting final product. The invention is characterized by high extract separatio rate, high total concentration of notoginsen triterpenes, strong physiologically activity and suitability for industrial production.

Description

technical field [0001] The invention belongs to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of Panax notoginseng saponins. Background technique [0002] Panax notoginseng is a perennial herbaceous plant of the genus Panax of the genus Araliaceae of the family Araliaceae. Modern research has found that the main function of Panax notoginseng is to prevent and treat cardiovascular and cerebrovascular diseases, and it also has a good effect on liver diseases and cancer. The total saponins of Panax notoginseng are the main effective parts of Panax notoginseng. The total saponins of Panax notoginseng have the effects of dilating blood vessels and inhibiting platelet aggregation, and also have the effects of anti-inflammation, analgesia, anti-aging, and enhancing immune function. The medicinal parts of Panax notoginseng include the stem base (reed head, cut mouth), main root, and branch root (tendon). The leaves of Panax no...

Claims

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Application Information

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IPC IPC(8): C07J17/00C07J9/00C07J71/00A61K36/285A61P9/10A61P7/02A61P29/00A61P37/04A61P43/00
Inventor 杨悦武叶正良郑永锋李旭
Owner TIANJIN TASLY ZHIJIAO PHARMA
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