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Manyzoned polypore glycopeptide production method and formulation thereof

A technology of versicolor glycopeptide and production method, which is applied in the field of natural medicine and can solve the problems of unfavorable, large volume and easy adhesion

Active Publication Date: 2012-09-26
SHANGHAI ZHICAO BIOTECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the volume of capsules is large, and patients with esophageal cancer have difficulty swallowing; capsules are mostly gelatin products, and gelatin is made of cow hooves or horns, so vegetarians should avoid it; moreover, capsules are easy to adhere to the stomach wall after entering the stomach. Stimulates gastric body agitation, also not good for gastric cancer or gastric ulcer patients

Method used

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  • Manyzoned polypore glycopeptide production method and formulation thereof
  • Manyzoned polypore glycopeptide production method and formulation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Yunzhi glycopeptide film-coated tablets with excess heavy metals removed

[0030] The production process of Yunzhi glycopeptide film-coated tablets is as follows:

[0031] Yunzhi submerged culture mycelium → hot water extraction, ethanol precipitation, to obtain Yunzhi glycopeptide → add microcrystalline cellulose and other auxiliary materials, and then granulate → press into tablet core (plain tablet) → → Coating, to obtain Yunzhi glycopeptide Film-coated tablet intermediate→The intermediate is bottled after passing the inspection to obtain the finished product.

[0032] 1. Production of Yunzhi Submerged Mycelia

[0033] The submerged mycelium of Versicolor versicolor is produced by three-stage fermentation: Strain: Cov-1, the slant strain is first placed in a conical flask and shaken at 25°C, and the medium is 5% corn flour, 1% glucose, pH6. 5. The oscillation frequency is 200rpm. After 7 days of oscillation culture, move the culture into a 200-liter seed...

Embodiment 2

[0050] Example 2: Coriolus versicolor glycopeptide granules with excess heavy metals removed

[0051] Put 50Kg of Yunzhi glycopeptide obtained in Example 1, which removes excess heavy metals, into a high-speed mixing granulator (HzSg-200 type), and another 4.0Kg of microcrystalline cellulose, stir and mix at high speed for 30 minutes, and then gradually add Contain 15L of 75% alcohol solution of 75g hydroxypropyl methylcellulose, start stirring and granulating flying knife button at the same time, stir and granulate for 30 minutes. Pass the above-mentioned granules through a 14-mesh medicine sieve, and dry at 60°C for 1 hour to obtain 57Kg of dry granules. Add 0.14Kg lubricant-magnesium stearate to the dry granules. After mixing, it can be divided into aluminum foil bags by a bagging machine. Each bag is filled with 1.1g of versicolor glycopeptide and sealed.

[0052] Each bag of Yunzhi Glycopeptide Granules contains 1.0g of Yunzhi Glycopeptide, which is equivalent to the cli...

Embodiment 3

[0053] Example 3: Yunzhi Glycopeptide Oral Liquid Removed from Excessive Heavy Metals

[0054] Get the Yunzhi glycopeptide 20Kg that removes excessive heavy metal that makes by embodiment one, trehalose 30Kg, erythritol 10Kg, xylooligosaccharide 6.5Kg, sodium aspartate 0.2Kg and taste nucleotide ( 1:1 mixture of 5' guanylic acid and 5' inosinic acid sodium) 0.2Kg, after fully mixing, add 1000L of pure water to dissolve, then press filter with 0.3μ microporous filter membrane, heat the filtrate to 98°C, keep After 60 minutes, it is filled into a glass bottle that has been sterilized in advance, and then it is sterilized after being capped. The volume of each bottle is 50ml, and it contains no less than 300mg of versicolor glycopeptide (calculated as glucose). Dosage: 3 times a day, 1 bottle (50ml) each time. This dose is the same as the daily clinical dose of Yunzhi Glycopeptide Capsules.

[0055] Table 2. The performance comparison between the original dosage form of Yunzhi...

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Abstract

The invention provides a method for preparing coriolan. It employs anti- chelating technology to prevent the chelating of glycopeptide with heavy metal, and makes the heavy content in coriolan meet international foodstuff sanitary standard. The coriolan prepared with method in this invention can be prepared into oral film clothing sheet tablet with medical findings, particles or oral liquid, which can be used to treat cancer and for health- care purpose.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to a production method of Yunzhi glycopeptide, in particular to a production method of Yunzhi glycopeptide capable of removing excessive heavy metals and a preparation thereof. Background technique [0002] Polysaccharopeptide of YunZhi (Polysaccharopeptide of YunZhi) is called PSP, which is a proteoglycan extracted from the mycelium of Yunzhi deep layer culture. Yunzhi glycopeptide is one of the two Yunzhi polysaccharide drugs recognized by the international medical community (Parris M. Kidd: The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment, in Alternative Medicine Review Vol.5, No.1, pp. 4-27, 2000. Solomon P.W. et al: Culinary-Medicinal Higher Basidiomycete Mushrooms as a Prominent Source of Dietary Supplements and Drugs for the 21 st Century. In Mushroom Biology and Mushroom Products, pp. 25-26, 2005). Yunzhi glycopeptide is used in tumo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P21/02A61K36/04A61K38/16A61K9/08A61K9/10A61K9/16A61K9/28A61P35/00C12R1/645
Inventor 杨庆尧杨晓彤
Owner SHANGHAI ZHICAO BIOTECH
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