Epsilon-caprolactone polymer

A polymer and caprolactone technology, applied in the field of ε-caprolactone polymers, can solve the problems of low glass transition temperature, slow degradation rate, strong crystallinity, etc.

Inactive Publication Date: 2007-12-19
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the defects of strong crystallinity, low glass transition temperature (Tg) and slow degradation rate of PCL, the application of PCL is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Mix 4-carbonyl-ε-caprolactone (OPD) and caprolactone at a molar ratio of 1:2 and add them to the polymerization reactor, with 1% of the molar number of 4-carbonyl-ε-caprolactone The stannous isooctanoate is used as a catalyst, and dry toluene is used as a solvent, and the copolymer is obtained after reacting at 80° C. for 18 hours.

[0018] The H NMR spectrum of the obtained copolymer ( 1 H-NMR) analysis: with d-CHCl 3 as the solvent, TMS as the internal standard, and use the German AVANCE500MHz nuclear magnetic resonance spectrometer to measure the hydrogen nuclear magnetic spectrum of the copolymer. COOCH 2 (δ=4.35, triplet), COCH 2 (δ=2.77, triplet), COOCH 2 (δ=4.08, triplet), COOCH 2 (δ=4.35, triplet) is the characteristic peak of the 4-carbonyl-ε-caprolactone structural unit in the polymer, COOCH 2 (δ=4.08, triplet) is the characteristic peak of the ε-caprolactone structural unit in the polymer, and can calculate 4-carbonyl-ε- in the polymer according to ...

Embodiment 2～3

[0026] 4-carbonyl-ε-caprolactone (OPD) and caprolactone are mixed at a molar ratio of 1:4 or 1:6 respectively and then added to the polymerization reactor, and can be obtained by the method of step (1) in Example 1 Copolymers with different molecular weights were analyzed by gel permeation chromatography (GPC). The molecular weight was calculated using a 244-type GPC tester from Waters Corporation of the United States, using tetrahydrofuran as the eluting solvent, and using polystyrene standard samples as the benchmark. The results are shown in Table 1

[0027] Table 1

[0028]

Embodiment 4～7

[0030] Only the molar ratio of reduction product to lactide in step (3) of Example 1 was changed (other conditions were the same as in Example 1). That is, the molar ratio of the reduction product to lactide is 1:40, 1:60, 1:80 or 1:100 respectively to obtain target objects with different molecular weights, and the resulting copolymer is analyzed by gel permeation chromatography (GPC). The 244 GPC tester of American Waters Company uses tetrahydrofuran as the eluting solvent, and the molecular weight calculation results are shown in Table 2 based on polystyrene standard samples.

[0031] Table 2

[0032]

instance number

Molar ratio of reduction product to lactide

M n a

×10 4

M w b

×10 4

The molecular weight distribution

(M w / M n )

1

4

5

6

7

1∶20

1∶40

1∶60

1∶80

1∶100

1.59

2.25

3.64

5.17

3.78

2.44 ...

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Abstract

The present invention relates to one kind of epsilon-caprolactone polymer capable of being used as biomedicine material. The epsilon-caprolactone polymer is prepared with 4-carbonyl-epsilon-caprolactone as initial material, and through the first homopolymerization to obtain homopolymer or copolymerization together with epsilon-caprolactone, delta-valerolactone, lactide and/or glycolide to obtain copolymer, the subsequent selective reduction of the homopolymer or copolymer, and the final graft copolymerization of the reduced product and epsilon-caprolactone, delta-valerolactone, lactide and/or glycolide to obtain the target product. The epsilon-caprolactone polymer of the present invention has controllable molecular weight, and thus controllable crystaallinity, hydrophilicity, degradation rate, etc.

Description

technical field [0001] The invention relates to an ε-caprolactone polymer, in particular to an ε-caprolactone polymer which can be used as a biomedical material. Background technique [0002] ε-caprolactone polymer (PCL), because of its good biocompatibility, is an ideal raw material for biomedical materials. However, due to the defects of strong crystallinity, low glass transition temperature (Tg) and slow degradation rate of PCL, the application of PCL is limited. Therefore, the modification of PCL is imperative. [0003] In order to meet different needs, different modification methods can be used. Such as: Wang Shenguo and others used the copolymerization method to prepare the copolymer of ε-caprolactone and ethylene glycol polyether, which overcomes the defect of slow degradation of PCL (Acta Polymer Sinica, 1995, 5: 560-565); Tarvainen et al. 2,2-bis(2-oxazoline) (2,2-bis(2-oxazoline)) is used as the chain mixing agent of PCL to adjust the degradation performance of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/91C08G63/08C08G63/85
Inventor 郎美东朱佳芸
Owner EAST CHINA UNIV OF SCI & TECH
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