Method for preparing L-ornithine-L-aspartate

A technology of aspartic acid salt and aspartic acid, which is applied in the preparation of organic compounds, chemical instruments and methods, and preparation of cyanide reaction, etc. It can solve the problems of low product yield, large water consumption, and environmental impact , to achieve process simplification, low raw material cost and energy consumption, and reduce the effects of three wastes treatment

Inactive Publication Date: 2008-01-09
上海依福瑞实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adopt the deficiency of said method to be: product yield is not high, only about 50%, and ion exchange prepares free ornithine and needs to use a large amount of resins, and water cons

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] 1. Put 3.8 kg of L-ornithine sulfate into 30.4 kg of distilled water, stir to dissolve, add 2.66 kg of L-aspartic acid, stir and heat to 45°C-50°C, and keep warm for 10 minutes.

[0008] 2. Add Ba(OH) to the reactant formed above 2 ·8H 2 O (barium hydroxide) 3.5 kilograms, and keep above-mentioned temperature and stir for 3.5 hours and then cool to room temperature, leave standstill for 7 hours, remove precipitated barium sulfate through filtration again.

[0009] 3. Add 0.45 kilograms of D403 large gap chelating type styrene ion exchange resin in the filtrate of above-mentioned removal of precipitate barium sulfate, filter after stirring at room temperature for 1.5 hours, and its filter residue is recyclable chelated barium ion ( Ba +2 ) D403 chelating resin, the filtrate was concentrated to 1.20 g / ml when the concentration of feed liquid was 1.20 g / ml at 50 DEG C of vacuum dehydration, and 0.2 kg of gac was added for decolorization in 40 minutes.

[0010] 4. Remove...

Embodiment 2

[0012] 1. Put 38 kg of L-ornithine sulfate into 296 kg of distilled water, stir to dissolve, then add 25.8 kg of L-aspartic acid, stir and heat to 45°C-50°C, and keep warm for 10 minutes.

[0013] 2. Add Ba(OH) to the reactant formed above 2 ·8H 2 O (barium hydroxide) 32.3 kilograms, and keep above-mentioned temperature and stir for 3 hours and then cool to room temperature, leave standstill for 6 hours, remove precipitated barium sulfate through filtration again.

[0014] 3. Add 3.8 kilograms of D403 large-gap chelating type styrene ion-exchange resin in the above-mentioned filtrate that removes barium sulfate, and filter after stirring at room temperature for 1 hour, and its filter residue is recyclable D403 chelating resin for reuse. When dehydrating and concentrating under vacuum at 50° C. until the concentration of the feed solution is 1.20 g / ml, add 2 kg of activated carbon and decolorize for 30 minutes.

[0015] 4. Remove activated carbon by filtration, heat the filtr...

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PUM

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Abstract

Production of L-2, 5-diaminovaleric acid-L-asparto salt by chemical synthesis is carried out by dissolving L-2, 5-diaminovaleric acid sulfate into distilled water, putting L-asparto, heating while dissolving, neutralizing sulfuric acid by barium hydroxide, cooling, filtering to remove diluted barium sulfate, chelating residual barium ion (Ba+2) by D403 chelate resin, filtering to remove chelating resin, decompressing while concentrating, de-coloring by activated carbon, filtering to remove activated carbon, agitating by anhydrous alcohol, heating, crystallizing under reflux state, filtering and drying to obtain final product. It avoids resin adsorption, resin recovery process and acid water treatment.

Description

Technical field: [0001] The invention relates to a preparation method of L-ornithine-L-aspartate, in particular to a method for preparing L-ornithine-L-aspartate by chemical synthesis. Background technique: [0002] The existing method for preparing L-ornithine-L-aspartate, such as German patent DE4 020 980 C1, uses arginase to convert arginine into ornithine, and in the reaction process, asparagine Amino acid adjusts its PH, and directly prepares this product. Another example is British Patents Brit.965,637 and Brit.1,067,742 and European Patent EP 0 477 991 A1, all of which use ornithine hydrochloride as raw material, adsorbed by cation exchange resin, and then eluted with 3-5% ammonia water, after concentration Add an equivalent amount of aspartic acid, then concentrate and add alcohol or acetone to obtain the product. The disadvantages of adopting the above method are: the product yield is not high, only about 50%, a large amount of resin is needed for the preparation ...

Claims

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Application Information

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IPC IPC(8): C07C227/14C07C229/24C07C229/26
Inventor 许云生许迎春许蓓仙葛邦錀
Owner 上海依福瑞实业有限公司
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