Method for synthesizing taurine

A synthetic method, the technology of taurine, applied in the preparation of sulfonic acid, organic chemistry, etc., can solve the problems of harsh production environment, difficult to accurately measure pH, difficult to control, etc., and achieve the effect of friendly production environment

Inactive Publication Date: 2008-01-09
JIANGSU YUANYANG PHARMA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0041] This method is difficult to control in the actual production process, it is difficult to accurately measure the pH value, and it is easy to add too much soda ash. What is more complicated is the separation of taurine and sodium sulfate. Separation of taurine and sodium sulfate (glauber's salt) at low temperature, accompanied by a large amount of SO 2 Gas, so that the production environment is extremely harsh, so there is an urgent need for a simple, economical and reliable clean production process that can separate taurine at low temperature

Method used

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  • Method for synthesizing taurine
  • Method for synthesizing taurine
  • Method for synthesizing taurine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Put ammonium bisulfite (50%) 588kg (2.97×10 3 mol), add ammonium bicarbonate 138kg (1.74×10 3 mol), until no carbon dioxide gas is released, add ethanolamine sulfate 352.5kg (2.5×10 3 mol), heating and stirring to 75°C, and maintaining the pressure in the kettle at -0.08MPa, after continuing to react for 60h, cooling down to 10°C while stirring, and centrifugal separation to obtain 360kg of crude taurine.

[0059] Put 360kg of the above-mentioned crude product taurine into a 1000L reactor, add 500L of water and 0.5kg of active carbon, dissolve the crude product taurine under heating and stirring, filter and remove the active carbon to obtain a colorless transparent liquid, and cool down to 5 ℃, centrifuged and washed to obtain 220kg of high-quality taurine, and dried to obtain 201kg of finished product taurine (1.61×10 3 mol), after testing, all the indicators are in line with the Japanese Pharmacopoeia JP8 edition and the United States Pharmacopoeia USP26 edition.

Embodiment 2

[0061] Add liquid ammonium bisulfite (50%) 650kg (3.29×10 3 mol), add equimolar ammonium bicarbonate, react under stirring to produce ammonium sulfite, and add ethanolamine hydrochloride 391kg (4.93×10 3 mol), heated and stirred to 90°C, and continued to react under normal pressure for 50h, then cooled down to 10°C under stirring, and centrifuged to obtain 430kg of crude taurine.

[0062] Put 430kg of the above crude taurine into a 1000L reaction kettle, add 500L of water and 1kg of activated carbon, dissolve the crude taurine under heating and stirring, filter out the activated carbon to obtain a colorless transparent liquid, and cool down to 10°C while stirring , centrifuged and washed to obtain 243kg of high-quality taurine, and dried to obtain 210kg of finished product taurine (1.68×10 3 mol), after testing, all indicators are in line with JP8 and USP26.

Embodiment 3

[0064] Add liquid ammonium bisulfite (50%) 645kg (3.29×10 3 mol), and added 450kg of ethanolamine phosphate (3.19×10 3 mol), pressurized to 0.4MPa, heated to 115°C and kept for 50h, cooled down to 10°C under stirring, and centrifuged to obtain 400kg of crude taurine.

[0065] Put 400kg of the above crude taurine into a 1000L reaction kettle, add 500L of water and 1kg of activated carbon, dissolve the crude taurine under heating and stirring, filter out the activated carbon to obtain a colorless transparent liquid, and cool down to 10°C while stirring , centrifuged and washed to obtain fine-quality taurine 225kg (1.8×10 3 mol), dried to obtain 200kg of finished taurine (1.6×10 3 mol), after testing, all indicators are in line with JP8 and USP26.

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Abstract

Synthesis of taurine is carried out by: reducing esterified product of cholamine with ammonium sulfite as reducer, separating to generate crude product, and re-crystallizing to obtain final product. It's economical, has no SO2 gas discharge and has friendly production environment and can separate out taurine and sulfate at low temperature.

Description

technical field [0001] The invention relates to a method for synthesizing taurine, which belongs to the technical field of organic chemical synthesis. Background technique [0002] Taurine, also known as taurine, is a sulfur-containing non-protein amino acid with a chemical name of 2-aminoethanesulfonic acid (NH 2 CH 2 CH 2 SO 3 H), in recent years along with the in-depth study to taurine physiological action, nutritive value, its application is also more and more widely, has important application in aspects such as medicine, food, fuel, tensio-active agent, pH buffering agent. As a drug, taurine can be used for choleretic, liver protection, detoxification, anti-inflammatory, antipyretic, sedative, anticonvulsant, antiarrhythmia, treatment of cardiac insufficiency, regulation of osmotic pressure, lowering blood pressure, treatment of arteriosclerosis, inhibition of central nervous system, maintenance of eyesight etc. At present, some developed countries in the world, su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/14C07C303/02
Inventor 陆昌元王剑峰
Owner JIANGSU YUANYANG PHARMA
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