Device and method for continuously back extracting penicillin

A penicillin and equipment technology, applied in the field of online automatic control continuous stripping penicillin, can solve the problems of organic phase product entrainment, unstable degradation of penicillin, emulsification, instability, etc., and achieve the effect of ensuring clarification time and inhibiting product degradation.

Inactive Publication Date: 2008-01-16
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantages of cumbersome penicillin stripping process in existing production, long operating time and instability, etc., and solve the unstable degradation and emulsification of penicillin in continuous production, entrainment of a large number of organic phase products, and unqualified heavy phase treatment In order to solve the problem that fluctuations in raw material titer are difficult to control, an online self-controlled continuous stripping penicillin equipment is provided

Method used

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  • Device and method for continuously back extracting penicillin
  • Device and method for continuously back extracting penicillin
  • Device and method for continuously back extracting penicillin

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] See Figure 1 and Figure 2. The equipment includes: eccentric wheel 5, exhaust valve 6, upper clarification section container 7, tray 8, central shaft 9, central shaft groove 10, heavy phase distributor 11, light phase distributor 12, lower clarification section container 13, electromagnetic Valves 14-1, 14-2, 14-3, 14-4, computer control system 15, cooling water jacket layer 16, polarimeter 17, pH meter probe 18, light phase distributor 19 in heavy phase clarification area, arc shaped baffle plate 20, tower body extension 21, laser particle size analyzer 22, return hole 23, injection pipe 25, filter 26, peristaltic pump 27, flange 28, inclined plate 29.

[0058] The two ends of a tower body are respectively the extraction tower of clarification section container, and its cylindrical tower body reaction extraction section adopts jacket layer 16 structure, and the clarification section container 7 of tower body upper end is larger than the clarification section container ...

Embodiment 2

[0069] The equipment of Example 1 was used. Concentration is 69010U / ml penicillin G organic solution and concentration is 25wt% potassium carbonate solution with 200l / h and 8.05l / h respectively under the condition of embodiment 1. The organic raffinate phase continuously flows out of the tower through the clarification section at the top of the tower and enters the intermediate storage tank for collection. The heavy phase rich in penicillin enters the collection tank continuously through the clarification section at the bottom of the tower controlled by a solenoid valve. The experimental results showed that there was no entrainment in the heavy phase and the organic raffinate phase; the potency of penicillin in the organic raffinate phase was 200-500 U / ml, and the pH of the heavy phase was 6.6-7.0; the yield of penicillin G was 90.6%.

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Abstract

The present invention relates to an equipment and the operation method for continuous penicillin stripping. An extraction tower is controlled by a computer control system; a cylindrical tower reaction extraction section adopts a jacketed structure; a clarification section container on the upper end of the tower body is larger than a clarification section container on the lower end of the tower body; a tower body extension section that extends into the upper clarification section container is bended outwards after a certain length of extension; a reflux hole is arranged on a straight tower body on the tower body extension section; an arc-shaped baffle plate with a downward arc core is arranged over the tower body extension section; a central shaft with a tower plate enters into the top of the upper clarification section container to make the bottom of the central shaft landed in a central shaft slot; a light phase distributor, a pH meter probe and a light phase in a heavy phase clarification area are arranged in the lower clarification section container; a laser particle size analyzer is arranged on a flange which connects the upper clarification section container with the tower body; a polarimeter is arranged on a pipe on an organic extraction raffinate phase exit. The invention can effectively inhibit the problems of penicillin degradation and milk slag handling, which can be applied to large-scale penicillin production through on-line automation control.

Description

technical field [0001] The invention belongs to the technical field of chemical separation engineering, and relates to an antibiotic production and extraction process and vibrating plate tower equipment, in particular to special equipment and an operation method for on-line self-controlled continuous back-extraction of penicillin from butyl acetate solution containing penicillin. Background technique [0002] Penicillin is currently the antibiotic with the largest production volume and the most widely used. It has the advantages of strong antibacterial effect, high curative effect, and low toxicity. It is the drug of choice for the treatment of sensitive bacterial infections. Penicillin is extremely unstable under strong acid or alkaline conditions, and its degradation rate is fast, especially under the condition of rising temperature; and it has the characteristics of large titer fluctuation, high phase ratio, and easy emulsification during the extraction process. At presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D499/18C07D499/48
Inventor 刘会洲申淑锋常志东安振涛王分良高任龙
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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