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Technology for preparing haw total phenolic acid part

A technology of total phenolic acid and hawthorn, which is applied in the field of medicine, can solve the problems of activity decline, etc., and achieve the effect of low cost, sufficient source of raw materials, and cheap price

Inactive Publication Date: 2008-03-19
上海永恒生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, it is believed that the total flavonoids in hawthorn play a pharmacological role, and there are also some patents on the separation and extraction of total flavonoids in hawthorn (such as application number: 01103986.8 and application number: 01118628.3), but we have found through research that when the hawthorn After the flavonoid content in the total flavonoid extract is further increased, the activity decreases instead

Method used

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  • Technology for preparing haw total phenolic acid part

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Preparation of effective part

[0038] Take 100kg of dried hawthorn leaves, grind them into coarse powder, and extract with 10 times the amount of 60% ethanol under reflux for three times, combine the extracts, concentrate under reduced pressure to 50L, place for precipitation, centrifuge, and pass the supernatant through AB-8 macroporous adsorption resin Chromatography, the water eluted part adjusted the pH value to 1, extracted with ethyl acetate, the extract was concentrated under reduced pressure, dissolved in water, and then chromatographed by AB-8 macroporous adsorption resin, eluted with water until the pH value was 3 to 5, continue to elute with 60% diacetone, concentrate the eluent under reduced pressure, and spray dry to obtain 0.52 kg of light yellow powder, which is the total phenolic acid fraction of hawthorn (the yield is 0.52% based on the crude drug amount). Through assay, the purity is 84.79%.

Embodiment 2

[0039] Embodiment 2: Preparation of effective fraction

[0040] Take 100 kg of dried hawthorn fruit, crush it, and extract it by percolation with 20 times the amount of 80% methanol, combine the percolation solution, concentrate it under reduced pressure to 50 L, place it for precipitation, centrifuge, and the supernatant is subjected to D101 macroporous adsorption resin chromatography, water After adjusting the pH value of the eluted part to 2, extract it with ethyl acetate, concentrate the extract under reduced pressure and dissolve it in water, then go through AB-8 macroporous adsorption resin chromatography, and elute with water until the pH value is 3-5. Continue to elute with 20% dilute ethanol, concentrate the eluate under reduced pressure, and spray dry to obtain 0.42 kg of light yellow powder, which is the total phenolic acid fraction of hawthorn (the yield is 0.42% based on crude drug amount). Through content determination, the purity is 67.25%.

Embodiment 3

[0041] Embodiment three: the preparation of tablet

[0042] Take 100g of the part of the present invention, 80g of starch, and 5g of dextrin, mix evenly, add 10% starch slurry to make soft material, granulate with a 14-mesh nylon screen, ventilate and dry at 60-70°C, granulate with a 16-mesh sieve, add stearic acid 1.5g of magnesium and 5g of sodium carboxymethyl starch were mixed evenly, pressed into 1000 tablets, and coated. Each tablet contains 100 mg of the site of the present invention. Adults take 2 to 5 times a day, 1 to 10 tablets each time.

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Abstract

The invention provides a technology of extracting the total phenolic acid part of hawthorn from the hawthorn leaf or the hawthorn fruit. The part can be used separately or matched with other medically permissive complementary material to be made into an oral preparation and an injection preparation. The part is fit for preventing and remedying various kinds of ischemic cardio-cerebrovascular diseases, senile dementia and hyperlipoidemia.

Description

[0001] This application is a divisional application of the invention patent application "Preparation process and application of total phenolic acid parts of hawthorn" with application number 03150544.9 submitted on August 26, 2003! Technical field: [0002] The invention belongs to the field of medicine, in particular to the preparation process and preparation of the total phenolic acid part isolated from hawthorn leaves or fruits and its potential application in medicine and health food. Background technique: [0003] Cardiovascular and cerebrovascular diseases are one of the diseases with higher incidence in the world. With the development of social economy and the improvement of people's living standards, the prevalence of cardiovascular and cerebrovascular diseases is also increasing year by year. According to relevant reports, in 2001, 56 million people died in the world. The two leading causes, coronary heart disease and stroke, are responsible for 7 million and 5.5 m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P9/10A61P25/28A61P3/06C07C51/47A61K127/00A61K131/00A61K9/08A61K9/10A61K9/14A61K9/20A61P9/00C07B63/00
Inventor 张蓉
Owner 上海永恒生物科技有限公司
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