In situ preparation method for nano zirconium oxide and hydroxyapatite composite powder

A technology of hydroxyapatite and nano-zirconia, applied in the field of medical materials

Inactive Publication Date: 2008-03-19
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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AI Technical Summary

Problems solved by technology

Nano-hydroxyapatite is a typical biological material with good biocompatibility and biological activity. Synthetic hydroxyapatite ceramics have the best affinity with the human body. A lot of research has been done on the synthesis method of limestone powder, and some progress has been made, but there are few reports on the in-situ preparation of nano-zirconia and hydroxyapatite composite powder.

Method used

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Embodiment Construction

[0028] Specific embodiments of the present invention are provided below.

[0029] The in-situ preparation method of nano-zirconia and hydroxyapatite composite powder of the present invention comprises the following production steps:

[0030] (1) In situ compounding

[0031] The "in-situ composite" mentioned here aims to combine less than 10% zirconia (ZrO 2 ) is evenly dispersed in hydroxyapatite (HA), so that the sintering temperature of the composite powder can be reduced, the biological activity of hydroxyapatite can be retained, and a composite filler with good dispersibility can be obtained.

[0032] Using 0.1mol / L zirconium oxychloride (ZrOCl 2 ), 0.0334mol / L calcium nitrate Ca(NO 3 ) 2 , 0.02mol / L diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 and 0.6mol / L ammonia water as raw materials, put them in the same reactor, the pH value of the reaction is 8-9, the reaction temperature is 80°C, and react for 6 hours under the action of a magnetic stirrer to prepare nano-s...

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Abstract

The invention is an in-situ preparation method of nanometer zirconium and hydroxyapatite compound powder. The method comprises the following steps: ''in-situ''- zirconium oxychloride, calcium nitrite, diammonium hydrogen phosphate and ammonia water are used as the raw materials, which are put in a same reactor by proportion; the pH value of the reaction is controlled in an alkaline range; a precursor of the nanometer zirconium and hydroxyapatite compound powder is prepared through the stirring action of a mixer at a higher reaction temperature; then after- ''ultrasonic treatment''-'' ethanol rinsing''-''calcination''-''grinding'', the nanometer zirconium and hydroxyapatite compound powder is obtained. The positive effect of the invention is that the prepared compound powder provides a novel way for the modification of the nanometer particle biological material. The invention can be used to prepare high performance bioceramic, which is applied for the replacement of the artificial implants and artificial joints; the invention can forms the nanometer compound fillers with different particle size and component, which are used for the synthesis of high performance nanometer compound materials. The invention has a significant meaning in the application of the medical materials.

Description

【Technical field】 [0001] The invention relates to the technical field of medical materials, in particular, it is a biomedical material mainly used for alveolar ridge enhancement, implants, tissue engineering brackets and crown and bridge repairs, and can also be used as a filler for existing polymers. Modified nano zirconia (ZrO 2 ) and the in-situ preparation method of hydroxyapatite (HA) composite powder. 【Background technique】 [0002] At present, on the technical level, the preparation of nano-zirconia (ZrO 2 ) and hydroxyapatite (HA) composite powder mainly in two ways: [0003] One is the "solid phase method", which is to combine hydroxyapatite (HA) with zirconia (ZrO 2 ) powders are mixed according to a certain ratio, and then subjected to mechanical ball milling to obtain nano-sized zirconia and hydroxyapatite composite powders. [0004] The other is the "liquid phase suspension method", which is made by adding zirconia (ZrO 2 ) powder into hydroxyapatite sol to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G25/02C01B25/32
Inventor 张修银朱邦尚于卫强李翔
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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