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An administer orally mixed nucleus glycosides as well as its preparing technics

A preparation process and nucleoside technology, which is applied in the field of oral mixed nucleosides and its preparation, can solve the problems of three-dimensional structure damage, long production cycle, high comprehensive cost, etc., and achieve the effects of reduced comprehensive cost, short production cycle and high biological activity

Active Publication Date: 2011-09-07
西安万隆制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides an oral mixed nucleoside and its preparation process to overcome the problems in the prior art that the three-dimensional structure of the product is destroyed to a certain extent, the production cycle is relatively long, the operation is difficult and the comprehensive cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Step (1) preparing barley root: select high-quality wheat or barley, remove impurities, and carry out soaking cultivation at a cultivation temperature of 18° C. at a cultivation temperature of 18° C. according to the ratio of wheat and water of 1:2, and the cultivation time is 7 days;

[0035] Step (2): Preprocessing

[0036] Water extraction: Put the malt root into the extraction barrel, add purified water for extraction.

[0037] Operation process:

[0038] Put 48Kg malt roots into 12 stainless steel barrels at 4Kg / barrel respectively, then add 480Kg purified water into 12 stainless steel barrels for leaching, the parts by weight of malt roots and purified water are 1:10, the leaching temperature 10°C, leaching time 25h. When filtering, squeeze and filter the soaked malt root solution with a 60-mesh filter cloth, and then vacuum filter the filtrate with a 200-mesh filter cloth after standing for 90 minutes; the oil temperature of the filtrate entering the interlayer ...

Embodiment 2

[0054] Step (1) preparing barley root: select high-quality wheat or barley, remove impurities, and carry out soaking cultivation at a cultivation temperature of 28° C. at a cultivation temperature of 28° C. for 4 days according to the ratio of wheat and water 1:5;

[0055] Step (2): Preprocessing

[0056] Water extraction: Put the malt root into the extraction barrel, add purified water for extraction.

[0057] Operation process: Put 48Kg of malt root into 12 stainless steel barrels at 4Kg / barrel, and then add 570Kg of purified water into 12 stainless steel barrels for leaching. The leaching temperature is 25°C, and the leaching time is 10h. Squeeze and filter the soaked malt root solution with a 60-mesh filter cloth, and then vacuum filter the filtrate with a 200-mesh filter cloth after standing for 70 minutes; preheat the filtrate into a stainless steel reactor with an interlayer oil temperature of 75±2°C After 50 minutes, quickly put the enzyme solution into the stainless ...

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Abstract

The invention belongs to the biology and pharmaceutical technical field, and relates to oral mixed nucleoside and the preparation process thereof. The invention mainly provides the oral mixed nucleoside and the preparation process thereof in order to overcome the problems existing in the prior art that the spatial structure of the product is damaged to a certain degree, the production cycle is longer, the operation is difficult, and the integrated cost is high. In order to overcome the problems existing in the prior art, the invention has the technical proposal that the oral mixed nucleoside is obtained through the following preparation processes, and the preparation processes comprise the steps that step one, malt roots are prepared; step two, pre-treatment: the malt roots are extracted through water, and filtered, after being preheated, phosphatase liquid is added to be prepared to be used; step three, hydrolytic reaction: purified water is preheated, and ribonucleic acid is added into the purified water, the pH value is adjusted, the mixed fluid in the step two is added into the purified water, the pH value is adjusted again, and the purified water is insulated and reacts; stepfour, the fluid is inactivated, the pH value is adjusted, and the fluid is filtered; step five, the fluid is concentrated and dried.

Description

Technical field: [0001] The invention belongs to the technical field of biopharmaceuticals, and relates to an oral mixed nucleoside and a preparation process thereof. Background technique: [0002] Nucleic acid is the most basic substance of life. Nucleotide is the main component of nucleic acid. The main components of mixed nucleosides are adenosine, guanosine, urine, and cytidine. Mixed nucleosides can promote and improve the nucleic acid metabolism of the human body, especially have unique curative effects on chronic hepatitis, diabetes and cardiovascular diseases. Antihypertensive effect. [0003] Mixed nucleosides are nucleic acid biochemical drugs. In the prior art, mixed nucleosides are prepared using animal ribonucleic acid (RNA) as a substrate and decomposed by physical and chemical methods to obtain mixed nucleosides. Its disadvantages are: 1. The decomposition method is unreasonable, which leads to the destruction of the three-dimensional structure of the mixed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K31/7052A61P1/16A61P3/10A61P9/10A61P9/12A61P35/00A61P37/04C12P19/38
Inventor 孙悦迎戴新萍党永孙晓蕾慕娟潘文岚
Owner 西安万隆制药股份有限公司
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