An administer orally mixed nucleus glycosides as well as its preparing technics

Abstract

The invention belongs to the biology and pharmaceutical technical field, and relates to oral mixed nucleoside and the preparation process thereof. The invention mainly provides the oral mixed nucleoside and the preparation process thereof in order to overcome the problems existing in the prior art that the spatial structure of the product is damaged to a certain degree, the production cycle is longer, the operation is difficult, and the integrated cost is high. In order to overcome the problems existing in the prior art, the invention has the technical proposal that the oral mixed nucleoside is obtained through the following preparation processes, and the preparation processes comprise the steps that step one, malt roots are prepared; step two, pre-treatment: the malt roots are extracted through water, and filtered, after being preheated, phosphatase liquid is added to be prepared to be used; step three, hydrolytic reaction: purified water is preheated, and ribonucleic acid is added into the purified water, the pH value is adjusted, the mixed fluid in the step two is added into the purified water, the pH value is adjusted again, and the purified water is insulated and reacts; stepfour, the fluid is inactivated, the pH value is adjusted, and the fluid is filtered; step five, the fluid is concentrated and dried.

Description

Technical field:

[0001] The invention belongs to the technical field of biopharmaceuticals, and relates to an oral mixed nucleoside and a preparation process thereof. Background technique:

[0002] Nucleic acid is the most basic substance of life. Nucleotide is the main component of nucleic acid. The main components of mixed nucleosides are adenosine, guanosine, urine, and cytidine. Mixed nucleosides can promote and improve the nucleic acid metabolism of the human body, especially have unique curative effects on chronic hepatitis, diabetes and cardiovascular diseases. Antihypertensive effect.

[0003] Mixed nucleosides are nucleic acid biochemical drugs. In the prior art, mixed nucleosides are prepared using animal ribonucleic acid (RNA) as a substrate and decomposed by physical and chemical methods to obtain mixed nucleosides. Its disadvantages are: 1. The decomposition method is unreasonable, which leads to the destruction of the three-dimensional structure of the mixed ...