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A relieving cough dropping pills and its preparing method

A drop pill and Baibu technology, applied in the field of cough drop pill and its preparation, can solve the problems of low utilization and slow dissolution, and achieve the effects of improved phagocytosis, fast dissolution speed and accelerated onset of effect

Inactive Publication Date: 2008-04-16
SHANGHAI HUATUO MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to extract a kind of extract miscible with polyethylene alcohol through a specific process, and then make it into an cough drop pill, so as to overcome the traditional medicinal material powder used in the prior art. The disadvantages of slow dissolution and low utilization

Method used

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  • A relieving cough dropping pills and its preparing method
  • A relieving cough dropping pills and its preparing method
  • A relieving cough dropping pills and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Here is an example of a preferred solution:

[0030] The matrix adopts polyethylene glycol 6000, and the weight ratio of the extract and the matrix is ​​1:1.

[0031] 1. Preparation of extract

[0032] (1) Take 9.2kg of herbal medicines, add 70% ethanol for reflux extraction twice, add 6 times the amount of ethanol for the first time, reflux extraction for 3 hours, add 4 times the amount of ethanol for the second time, reflux extraction for 2 hours, and combine ethanol extraction liquid, filtered, recovered ethanol, and water for later use.

[0033] (2) Take 9.2kg of Peucedanum herb, add water to decoct three times, add 10 times the amount of water for the first time, decoct for 3 hours, add 6 times the amount of water for the second time, decoct for 1 hour, and add 4 times the amount for the third time water, decocting for 0.5 hours. Combine the decoctions, filter, combine the filtrate with the water of Baibu, concentrate under reduced pressure to 2g crude drug / ml, ...

Embodiment 2

[0044] Choose different matrices to carry out the experiment of formulating.

[0045] Using polyethylene glycol 4000 as the base, mix the extract and the base evenly at a ratio of 1:1, and follow the steps specified in Example 1 for the rest, heat the prepared materials of each group until melting, and use the dripping pill Machine, adjust its temperature control system to meet the requirements of the sixth step of the preparation process in Example 1, use methyl silicone oil as a condensing agent, prepare according to the process given in Example 1, and use Polymerization in Example 1 For the comparison of ethylene glycol 6000 as the matrix, see the attached table 1 for the experimental results.

[0046] Table 1 Experiments of mixing extracts with different matrices

[0047]

[0048] Note: The symbol "-" in the attached table means slightly worse, "+" means average, and "++" means better.

Embodiment 3

[0050] Experiments with different ratios of extract and matrix.

[0051] In order to investigate the influence of the extract and the matrix in different ratios on the products involved in the present invention, the extract and the matrix are mixed evenly with the ratio of 1:0.5, 1:1, 1:3, and 1:5 respectively, and the matrix is ​​selected. Polyethylene glycol 6000, and others are all according to the steps specified in Example 1. The prepared materials of each group are heated to melt respectively, and the temperature control system is adjusted to meet the sixth step of the preparation process in Example 1 by using a dropping pill machine. requirements, using methyl silicone oil as a condensing agent, and preparing according to the process given in Example 1, 4 recipe experiments with different ratios of extract and matrix were obtained, and 4 groups of different experimental results were obtained, see the attached table 2.

[0052] Table 2 Experiments of different ratios of...

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PUM

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Abstract

The present invention relates to a cough-relieving drop pill and its preparation method. The method is: extracting stemona sessilifolia, peucedanum and prunus persica, then with polyethylene as matrix, the weight ratio of extract and polyethylene is 1:0.5 to 1:5, preparing drop pill. The preparation method is simple, suitable for industrial production. The cough-relieving drop pill prepared by the method is used for treating cough, abundant sputum, asthma, infantile pertussis and acute and chronic tracheitis.

Description

technical field [0001] The invention relates to a drop pill for cough, excessive phlegm, asthma, pertussis in children and acute and chronic bronchitis, in particular to a cough drop pill and a preparation method thereof. Background technique [0002] Herba Fructus is sweet in nature, bitter, tepor. Return lung meridian. It has the effect of nourishing the lungs, lowering the qi and relieving cough, and is used to treat chronic cough, tuberculosis cough, whooping cough, etc. Fructus Peucedanum nature is bitter, pungent, be slightly cold. Return lung meridian. It has the effects of dispelling wind and clearing heat, reducing qi and resolving phlegm, and is used for treating wind-heat cough with excessive phlegm, panting with phlegm-heat, and expectoration of yellow and thick phlegm. Bitter almonds are bitter in nature and slightly warm. Return lung, large intestine channel. It has the effect of lowering Qi, relieving cough and relieving asthma. For the treatment of cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/20A61P11/14A61P11/10A61P11/06A61P11/00
Inventor 付荣杰徐波孙兆林潘俊芳
Owner SHANGHAI HUATUO MEDICAL SCI CO LTD
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