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Gallo catechin and gallate microcapsule granule and preparation technique thereof

A technology of epigallocatechin and gallate, applied in the field of hydrophobic microcapsules, can solve the problem of high drug loading, and achieve the effects of good stability, good fluidity and good encapsulation effect

Active Publication Date: 2008-04-30
GUANGDONG LAB ANIMALS MONITORING INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems that epigallocatechin gallate (EGCG) is not suitable for industrial application such as easy oxidation, hygroscopicity and fluidity, the present invention develops a kind of EGCG microcapsule, which solves the problem of hygroscopicity and stability of EGCG powder. , Good fluidity, high dissolution rate, achieving the purpose of slow release and controlled release, and high drug loading

Method used

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  • Gallo catechin and gallate microcapsule granule and preparation technique thereof

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Embodiment 1

[0026] Embodiment 1. A kind of epigallocatechin gallate microcapsule particle, it is made up of the composition of following weight ratio:

[0027] Epigallocatechin gallate 2,

[0028] Ethyl cellulose 1

[0029] Polyethylene glycol 0.1,

[0030] Sodium carboxymethyl starch 1.8.

[0031] Its preparation process is:

[0032] (1) The ethyl cellulose of 1 weight part is dissolved in the dichloromethane, prepares the concentration that obtains the ethyl cellulose solution at 5% (g / v),

[0033] (2) Add 2 parts by weight of epigallocatechin gallate, 0.1 parts by weight of polyethylene glycol and sodium carboxymethyl starch of 1.8 parts by weight in the above-mentioned ethyl cellulose solution, stir to make it fully suspended, The stirring speed is controlled at 1500 rpm, and petroleum ether is slowly added dropwise until the system is completely precipitated, and the precipitated microcapsules are separated from the solvent to obtain a mixture of cysts and solvent A, and the cyst...

Embodiment 2

[0034] Embodiment 2. A kind of epigallocatechin gallate microcapsule particle, it is made up of the composition of following weight ratio:

[0035] Epigallocatechin gallate 3,

[0036] Ethyl cellulose 1

[0037] Polyethylene glycol 0.2

[0038] Sodium carboxymethyl starch 0.5.

[0039] Its preparation process is:

[0040] (1) The ethyl cellulose of 1 weight part is dissolved in the dichloromethane, prepares the concentration that obtains the ethyl cellulose solution at 6% (g / v),

[0041] (2) Add 3 parts by weight of epigallocatechin gallate, 0.2 parts by weight of polyethylene glycol and sodium carboxymethyl starch of 0.5 parts by weight in the above-mentioned ethyl cellulose solution, stir to make it fully suspended, The stirring speed is controlled at 1500 rpm, and petroleum ether is slowly added dropwise until the system is completely precipitated, and the precipitated microcapsules are separated from the solvent to obtain a mixture of cysts and solvent A, and the cysts...

Embodiment 3

[0042] Embodiment 3. A kind of epigallocatechin gallate microcapsule particle, it is made up of the composition of following weight ratio:

[0043] Epigallocatechin gallate 2,

[0044] Ethyl cellulose 1.5

[0045] Polyethylene glycol 0.05,

[0046] Sodium Carboxymethyl Starch 1.

[0047] Its preparation process is:

[0048] (1) Dissolve 1.5 parts by weight of ethyl cellulose in the fraction <45°C under normal pressure of the solvent mixture A separated by the above-mentioned method one, and prepare the ethyl cellulose solution with a concentration of 7% (g / v),

[0049] (2) Add 2 parts by weight of epigallocatechin gallate, 0.05 parts by weight of polyethylene glycol and sodium carboxymethyl starch of 1 part by weight in the above-mentioned ethyl cellulose solution, stir to make it fully suspended, Control the stirring speed at 1500 rev / min, slowly add dropwise the distillate of the solvent mixture A separated from the above-mentioned method under normal pressure > 60°C, ...

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Abstract

The invention relates to an epigallocatechin gallate (EGCG) microcapsule particle and a preparation process thereof. The microcapsule particle uses epigallocatechin gallate as a capsule core, and ethyl cellulose (EC) and / or polyethylene glycol (PEG) as the capsule material, using carboxymethyl starch sodium (CMS-Na) as the accelerator, the prepared microcapsule particles have good stability, and solve the problem of epigallocatechin gallate Hygroscopicity and fluidity problems, the final product granules have good encapsulation effect, high yield, stable dissolution rate, and can be used for the development and utilization of drugs, food, feed, etc.

Description

technical field [0001] The invention relates to a hydrophobic microcapsule with epigallocatechin gallate (EGCG) as the capsule core and a preparation process thereof. Background technique [0002] Epigallocatechin gallate (EGCG), the main component of tea polyphenols, is widely distributed in medicinal plants. As a natural antioxidant and free radical scavenger, it has been widely used in food, medicine (including Veterinary medicine), feed and chemical industry, modern pharmacological research shows that EGCG has anti-tumor, anti-thrombosis, anti-oxidation, anti-aging, anti-bacterial and virus effects. [0003] However, because the phenolic hydroxyl group in the EGCG molecule is very active, it is easy to absorb moisture, oxidize, polymerize or condense, etc., thereby degrading a variety of substances and having poor stability. In addition, due to the poor fluidity of EGCG, it is not conducive to the sub-dose packaging of pharmaceutical dosage forms, so that it is subject ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/50A61K47/38A61P7/02A61P31/04A61P31/12A61P35/00A61P39/06
Inventor 黄韧郭震
Owner GUANGDONG LAB ANIMALS MONITORING INST
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