Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones

A technology of methylpyridoxine and its extract, which is applied in food preparation, medical raw materials derived from ginkgo biloba, drug combination, etc.

Inactive Publication Date: 2008-05-07
DR VILMAR SHVABE GMBKH EHND KO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, depending on constraints that may be established in the future and in view of the requirement to modify th...

Method used

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  • Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones
  • Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones

Examples

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Effect test

example 1

[0066] Example 1: Ginkgo biloba extract with reduced content of 4'-O-methylpyridoxine

[0067] 1249g of the extract solution obtained according to the above preparation method was adjusted with water until the ethanol content was about 40% (w / w) and applied to 50ml (corresponding to 0.28ml per gram of dry extract) Amberlite IR-120 (strongly acidic ion exchanger) ) (Tubular column: about 2×16.5 cm; flow rate: about 8 ml / min) (step I)), followed by flushing with 200 ml of 50% ethanol (w / w). The resulting solution was concentrated on a rotary evaporator and dried in vacuum at 50°C (step m)): 179.4 g.

[0068] It can be seen from the following table that the content of 4'-O-methylpyridoxine of 0.4 ppm is achieved without basically changing the content of the components related to the efficacy.

example 2

[0071] Example 2a): Ginkgo biloba extract with reduced content of diflavonoids

[0072] 500g of the extract solution obtained according to the above preparation method was adjusted with water until the ethanol content was about 40% (w / w) and applied to 400ml (corresponding to 5.7ml per gram of dry extract) Sepabeads SP-850 (adsorbent resin) ( Column: about 4×32 cm; flow rate: about 8 ml / min) (step 1)), followed by flushing with a total of about 2 liters of 40% ethanol (w / w). 10% (259.3 g) of the resulting solution was concentrated on a rotary evaporator and freeze-dried (step m)): 6.92 g. The remaining 90% of the solution was used in Example 2b).

[0073] It can be seen from the following table that the content of diflavonoids of less than 1 ppm is achieved under the condition that the content of the ingredients related to the efficacy is basically unchanged.

example 2

[0074] Example 2b): Ginkgo biloba extract with reduced content of 4'-O-methylpyridoxine and diflavonoids

[0075] 90% (2334.1g) of the solution obtained in Example 2a) was applied to 25ml (corresponding to 0.40ml per gram of dry extract) Amberlite IR-120 (strongly acidic ion exchanger) (column: about 1.5×11cm; Flow rate: about 10ml / min) (step 1)), followed by flushing with 100ml 40% ethanol (w / w). The resulting solution was concentrated on a rotary evaporator and freeze-dried (step m)): 61.67 g.

[0076] It can be seen from the table below that the 4'-O-methylpyridoxine content of 0.4 ppm and the diflavonoid content of less than 1 ppm were achieved under the condition that the content of the components related to the efficacy was basically unchanged.

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Abstract

The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Description

Technical field [0001] The present invention relates to an improved multi-step method for preparing a ginkgobiloba extract with a reduced content of 4'-O-methylpyridoxine and / or diflavonoids, wherein the elimination is through an adsorbent resin and / or ion exchange Agent filtration is achieved and the material to be removed remains on the resin. The present invention further relates to a ginkgo extract with a reduced content of 4'-O-methylpyridoxine and / or diflavonoids obtainable by the method of the present invention, and its use. Background technique [0002] For decades, Ginkgo biloba extract has been used as a medicine. Currently, it is used to treat various dementias and their symptoms, as well as brain and peripheral blood circulation disorders. The ingredients related to efficacy are terpene lactones (ginkgolide A, B and C and bilobalide) and glycosides of flavonoids (quercetin, kaempferol and isoforms). Rhamnetin (isorhamnetin)). Ginkgo biloba also contains components tha...

Claims

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Application Information

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IPC IPC(8): A61K36/00
CPCA23L1/3004A61K36/16A23L33/11A61P25/00A61P25/28A61P7/00A61P9/00A61P9/02A61P9/08A61P9/10A61K31/445A61K31/353
Inventor 克莱门斯·埃德尔迈尔荷尔曼·休格伊哥·酷克福瑞德须·朗
Owner DR VILMAR SHVABE GMBKH EHND KO KG
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