Supercharge Your Innovation With Domain-Expert AI Agents!

Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones

A technology of methylpyridoxine and its extract, which is applied in food preparation, medical raw materials derived from ginkgo biloba, drug combination, etc.

Inactive Publication Date: 2008-05-07
DR VILMAR SHVABE GMBKH EHND KO KG
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, depending on constraints that may be established in the future and in view of the requirement to modify the extraction composition as little as possible, it may be desirable to remove only the biflavones or 4'-O-methylpyridoxine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones
  • Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0066] Example 1: Ginkgo biloba extract with reduced content of 4'-O-methylpyridoxine

[0067] 1249g of the extract solution obtained according to the above preparation method was adjusted with water until the ethanol content was about 40% (w / w) and applied to 50ml (corresponding to 0.28ml per gram of dry extract) Amberlite IR-120 (strongly acidic ion exchanger) ) (Tubular column: about 2×16.5 cm; flow rate: about 8 ml / min) (step I)), followed by flushing with 200 ml of 50% ethanol (w / w). The resulting solution was concentrated on a rotary evaporator and dried in vacuum at 50°C (step m)): 179.4 g.

[0068] It can be seen from the following table that the content of 4'-O-methylpyridoxine of 0.4 ppm is achieved without basically changing the content of the components related to the efficacy.

example 2

[0071] Example 2a): Ginkgo biloba extract with reduced content of diflavonoids

[0072] 500g of the extract solution obtained according to the above preparation method was adjusted with water until the ethanol content was about 40% (w / w) and applied to 400ml (corresponding to 5.7ml per gram of dry extract) Sepabeads SP-850 (adsorbent resin) ( Column: about 4×32 cm; flow rate: about 8 ml / min) (step 1)), followed by flushing with a total of about 2 liters of 40% ethanol (w / w). 10% (259.3 g) of the resulting solution was concentrated on a rotary evaporator and freeze-dried (step m)): 6.92 g. The remaining 90% of the solution was used in Example 2b).

[0073] It can be seen from the following table that the content of diflavonoids of less than 1 ppm is achieved under the condition that the content of the ingredients related to the efficacy is basically unchanged.

example 2

[0074] Example 2b): Ginkgo biloba extract with reduced content of 4'-O-methylpyridoxine and diflavonoids

[0075] 90% (2334.1g) of the solution obtained in Example 2a) was applied to 25ml (corresponding to 0.40ml per gram of dry extract) Amberlite IR-120 (strongly acidic ion exchanger) (column: about 1.5×11cm; Flow rate: about 10ml / min) (step 1)), followed by flushing with 100ml 40% ethanol (w / w). The resulting solution was concentrated on a rotary evaporator and freeze-dried (step m)): 61.67 g.

[0076] It can be seen from the table below that the 4'-O-methylpyridoxine content of 0.4 ppm and the diflavonoid content of less than 1 ppm were achieved under the condition that the content of the components related to the efficacy was basically unchanged.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and / or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and / or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and / or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Description

Technical field [0001] The present invention relates to an improved multi-step method for preparing a ginkgobiloba extract with a reduced content of 4'-O-methylpyridoxine and / or diflavonoids, wherein the elimination is through an adsorbent resin and / or ion exchange Agent filtration is achieved and the material to be removed remains on the resin. The present invention further relates to a ginkgo extract with a reduced content of 4'-O-methylpyridoxine and / or diflavonoids obtainable by the method of the present invention, and its use. Background technique [0002] For decades, Ginkgo biloba extract has been used as a medicine. Currently, it is used to treat various dementias and their symptoms, as well as brain and peripheral blood circulation disorders. The ingredients related to efficacy are terpene lactones (ginkgolide A, B and C and bilobalide) and glycosides of flavonoids (quercetin, kaempferol and isoforms). Rhamnetin (isorhamnetin)). Ginkgo biloba also contains components tha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/00
CPCA23L1/3004A61K36/16A23L33/11A61P25/00A61P25/28A61P7/00A61P9/00A61P9/02A61P9/08A61P9/10A61K31/445A61K31/353
Inventor 克莱门斯·埃德尔迈尔荷尔曼·休格伊哥·酷克福瑞德须·朗
Owner DR VILMAR SHVABE GMBKH EHND KO KG
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com