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Method for enriching active ingredient of seal oil

An active ingredient, the technology of seal oil, applied in the direction of oil/fat refining, fat production, etc., can solve the problems of many steps, complicated process, limited application of seal oil, etc., and achieve the effect of short residence time and simple process

Inactive Publication Date: 2008-05-14
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned high-vacuum rectification method or molecular distillation method, in order to reduce the boiling point of raw materials, has carried out esterification, brought into a small amount of organic solvents in this process, makes the final product contain a small amount of organic solvents, greatly limits seal oil as a kind of natural The application of medicines and health care products; then carry out molecular distillation or high-vacuum rectification and purification to enrich the active ingredients of unsaturated fatty acids, and then deesterify to obtain seal essential oil. The enrichment method needs to go through esterification and deesterification processes, with many steps and complicated processes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In the feeder of self-made molecular distillation device (feeder volume 300ml, evaporation area 1.2 square meters, wiper rotating speed 100~1000rpm), add 1L seal oil crude product, containing 3-PUFA 17.4%. Turn on the raw material preheating device and raise the temperature to 100°C. Turn on the cooling device and keep the cooling temperature at 40°C (the condensation temperature should not be too low to cause the viscosity of the distillate to be too high and affect the flow), add liquid nitrogen to the cold trap, turn on the rotary vane vacuum pump, and make the operating pressure of the system reach 1.5 Pa, turn on the oil diffusion pump after 20 minutes, and the system pressure reaches 0.6Pa. Turn on the precision constant temperature tank for evaporating materials to heat the heat transfer oil, make the temperature stable to 180°C first, then set the temperature to 290°C, and start feeding after reaching the target temperature, the feeding rate is 20mL / min, the wip...

Embodiment 2

[0016] In the feeder of self-made molecular distillation device (same as above), add 1L seal oil crude product, contain 3-PUFA 18.8%. Turn on the raw material preheating device and raise the temperature to 100°C. Turn on the cooling device, keep the cooling temperature at 50°C, add liquid nitrogen to the cold trap, turn on the rotary vane vacuum pump, and make the operating pressure of the system reach 1.5Pa, turn on the oil diffusion pump after 20 minutes, and the system pressure reaches 0.8Pa. Turn on the precision constant temperature tank for evaporating materials to heat the heat transfer oil, make the temperature stable to 180°C first, then set the temperature to 310°C, and start feeding after reaching the target temperature, the feeding rate is 60mL / min, the wiper The rotating speed is 300rpm. After the distillation process, 486mL of distillate and 505mL of heavy fraction are obtained; the content of 3-PUFA in the final product reaches 28.3%.

Embodiment 3

[0018] Add 1L crude seal oil, containing 3-PUFA15.3%, into the feeder of the self-made molecular distillation device (same as above). Turn on the raw material preheating device and raise the temperature to 100°C. Turn on the cooling device, keep the cooling temperature at 60°C, add liquid nitrogen to the cold trap, turn on the rotary vane vacuum pump, so that the operating pressure of the system reaches 1.5Pa, and turn on the oil diffusion pump after 20 minutes, and the system pressure reaches 0.1Pa. Turn on the precision constant temperature tank for evaporating materials to heat the heat transfer oil, make the temperature stable to 180°C first, then set the temperature to 330°C, and start feeding after reaching the target temperature. The feed rate is 80mL / min, and the wiper The rotating speed is 350rpm. After the distillation process, 484mL of distillate and 504mL of heavy fraction are obtained; the content of 3-PUFA in the final product reaches 27.6%.

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Abstract

The invention discloses a method for enriching active ingredients from fur seal crude oil. The existing method makes the final product contain a small amount of organic solvent, which greatly limits the application of seal oil as a natural medicine and health care product; the enrichment method needs to go through esterification and deesterification processes, with many steps and complicated processes. In the present invention, crude seal oil is used as raw material, purified by molecular distillation, and unsaturated fatty acids are enriched in effective components to obtain seal essential oil. The evaporation temperature is 290-330°C. Under the conditions of high flow rate and high distillation temperature, the invention does not need esterification, has simple process, short residence time, and no pollution to the environment; the enriched seal essential oil is especially suitable for application in natural medicines and health care products.

Description

technical field [0001] The invention relates to a method for enriching active ingredient omega-3 unsaturated fatty acid (3-PUFA) from fur seal crude oil. Background technique [0002] Fur seal is a kind of marine mammal covered with bristles all over the body, living in the arctic alpine waters (-40 ℃) for many years, its body contains a large amount of unsaturated fatty acids - mainly including eicosapentaenoic acid (EPA), two Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). Patents such as CN1679626, CN1437955, CN1435186, CN1518990, CN1410076 and CN1410077 have reported the application of seal oil: for the preparation of health products for the prevention and treatment of chemical liver damage; for the preparation of drugs for the prevention and treatment of menopausal syndrome; for the preparation of drugs for the prevention and treatment of senile dementia; It is a health product for spots, acne and pregnancy spots; it also has special effects in the treatmen...

Claims

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Application Information

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IPC IPC(8): C11B3/00
Inventor 应安国叶伟东
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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