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Ginkgo leaf extract and preparing method thereof

A technology of extract and ginkgo biloba, which is applied in the field of preparation of the extract, can solve the problems of low content, inability to scale up, and high cost, and achieve the effect of improving curative effect and reducing dosage

Active Publication Date: 2008-06-18
YANGTZE RIVER PHARMA GRP JIA NGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used preparation methods of ginkgo leaf extract at home and abroad include resin adsorption separation, CO2 supercritical extraction and other methods. These methods have disadvantages such as low content increase or high cost or inability to scale up.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment one: the preparation of ginkgo leaf extract and tablet thereof of the present invention

[0015] Weigh commercially available Ginkgo biloba extract, wherein flavonol glycoside content 24% (W / W), lactone content 6% (W / W) 1kg, reflux extraction with 6 times of petroleum ether, discard petroleum ether solution , the residue was vacuum-dried at low temperature, extracted twice with 6 times the amount of ethyl acetate under reflux, and the extract and residue were collected and processed separately.

[0016] Take the above-mentioned ethyl acetate reflux liquid, recover ethyl acetate under reduced pressure, add 2 times the amount of acetone to the residue to dissolve, add the same amount of hot water to mix evenly, let stand, refrigerate, precipitate lactone, filter, and dissolve the lactone with methanol Aluminum oxide column, eluting with methanol, recovering methanol to dryness, obtained 93g of refined lactone, determined by high performance liquid chromatograph...

Embodiment 2

[0020] Embodiment two: the preparation of ginkgo biloba injection

[0021] prescription

[0022] Refined Ginkgo Biloba Extract 8.8g

[0023] Sodium chloride 90g

[0024] Tween 80 appropriate amount

[0025] Add water for injection to 10000ml

[0026] Take the prescription amount of refined ginkgo biloba extract, add 80% (W / W) water for injection, stir, add appropriate amount of Tween 80 to dissolve, add sodium chloride, stir to dissolve, add 0.05% (W / W) activated carbon to keep warm After 20 minutes, filter, adjust the pH value to 5-7, add water to a sufficient amount, filter through a 0.2um microporous membrane, pack into 100ml / bottle, and sterilize at 105°C for 30 minutes to obtain the product.

Embodiment 3

[0027] Embodiment three: the preparation of ginkgo leaf freeze-dried powder injection

[0028] prescription:

[0029] Refined Ginkgo Biloba Extract 8.8g

[0030] Hydroxypropyl Beta Cyclodextrin 10g

[0031] Add water for injection to 200ml

[0032] Take the prescribed amount of hydroxypropyl beta-cyclodextrin, stir and dissolve in 80% water for injection, add the refined extract of ginkgo biloba, stir and dissolve, add 0.05% (W / W) activated carbon to keep warm for 20 minutes, filter, and adjust the pH value to 5 ~7, add water to a sufficient amount, filter with a 0.2um microporous membrane, pack into 2ml / bottle, and freeze-dry to obtain.

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PUM

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Abstract

Disclosed are an extract of ginkgo biloba and a preparation method of the extract. The contents of the controllable components of the liquid phase of the extract reach more than 80 percent; wherein, the content of flavonol glycosides is more than 74 percent; and the content of lactone is more than 6 percent. The preparation method is that extracts of the ordinary ginkgo biloba sold in the market are separated and purified by dephenolization acid, AB-8 resin, polyamide resin and alumina, and then two components containing 90 percent of flavonoids and 50 percent of lactone are respectively made; and the two components are mixed in the proportion of 6: 1. The refined extracts not only can be made into solid oral preparation to reduce the drug dose but also can be made into injection according to the latest requirements of the new drug in the registration provisions in China, and the injection is used to treat cardiovascular and cerebrovascular diseases, taking effect fast.

Description

technical field [0001] The invention relates to a ginkgo leaf extract, which is refined by using the commercially available ginkgo leaf extract as a raw material, and also relates to a preparation method of the extract. Background technique [0002] Cardiovascular and cerebrovascular diseases are common clinical diseases and frequently-occurring diseases. The disease is characterized by a long course of disease, is difficult to cure, and has a high mortality rate. At present, although there are many drugs for the treatment of cardiovascular and cerebrovascular diseases in Western medicine, their clinical use is limited due to large side effects or other reasons. Ginkgo biloba preparations have always been popular with doctors and patients in the treatment of cardiovascular and cerebrovascular diseases. However, due to factors such as low content of active ingredients, large dosage, oral dosage forms, and uncertain curative effects, it is generally used as an adjuvant therapy...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K47/40A61P9/10A61K127/00
Inventor 彭国平陆宏国陈国俊王继亮尹必喜
Owner YANGTZE RIVER PHARMA GRP JIA NGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE CO LTD
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