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Method for preparing calcium magnesium gluconate

The technology of calcium gluconate and gluconic acid is applied in the field of preparation of calcium and magnesium supplementary preparation calcium and magnesium gluconate, and achieves the effects of strong market competitiveness, excellent solubility and heat resistance stability

Inactive Publication Date: 2011-08-24
ZHEJIANG ENGLA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the calcium gluconate is used to supplement calcium in the market, and the combination of calcium and magnesium is relatively small.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Wash 1000g of shells, roast them in a high-temperature electric furnace at 1000-1200°C for 1 hour, extract calcium oxide and trace mineral elements, add 150g of food-grade magnesium sulfate powder, and react with L-lactic acid or L-lactic acid and gluconic acid to form Calcium magnesium lactate or calcium magnesium lactate gluconate 613g, then add 40%-45wt% sodium hydroxide for deacetylation reaction to obtain calcium magnesium gluconate.

Embodiment 2

[0018] The calcium magnesium gluconate prepared by the method is white granular powder, odorless and tasteless, easily soluble in boiling water, slowly dissolved in water, and insoluble in absolute ethanol, chloroform or ether. Get this product and carry out the release test according to the release test method (Chinese Pharmacopoeia version two appendix XD first method in 1995), with hydrochloric acid solution (9 → 1000ml) 900ml as solvent, rotating speed is 100 revolutions per minute, according to the law, at 1.5 Take a 10ml sample every hour and filter, and the filtrate is set aside. Discard the hydrochloric acid solvent, and replace it with 900ml of potassium dihydrogen phosphate-sodium hydroxide buffer solution with pH 6.8 as the solvent, operate according to the law, take 10ml of samples and filter them at 4, 8, and 14 hours (in total time), and immediately in the Add 10ml of pH 6.8 buffer solution to the operating container. Get filtrate, according to spectrophotometry...

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PUM

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Abstract

The invention relates to a preparation method for calcium magnesium gluconate. The method is characterized in that the calcium magnesium gluconate is obtained by adding oxide of calcium into magnesium and L2 lactic acid or L2 lactic acid gluconic acid for reaction. The oxide of calcium adopts a shell as raw material, which is baked at the temperature of 1000-1200 DEG C. By the design of the best ratio of calcium and magnesium suitable for human absorption and retaining other trace mineral elements contained in the shell, the invention is best for human absorption of mineral substance.

Description

(1) Technical field [0001] The invention relates to a preparation method of calcium magnesium gluconate supplement preparation. (2) Background technology [0002] The value of pearls is high, but the oysters that produce pearls suddenly lose their color after breeding pearls and are abandoned by others. Except for a small part being utilized, most of them are discarded and cause environmental pollution. In fact, clam shells have high utilization value. If they can be used, they can not only solve the problem of environmental pollution, but also turn them into wealth and form a virtuous circle. [0003] At present, most of the products in the market use calcium gluconate to supplement calcium, and few combine calcium and magnesium together. Commercially available calcium and magnesium tablets also mostly supplement calcium and magnesium in the form of carbonate. (3) Contents of the invention [0004] The purpose of the present invention is to provide a novel combination ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C59/105C07C51/43
Inventor 陈海军李小龙翁学庆黄德年焦瑞芳王益军王晶
Owner ZHEJIANG ENGLA PHARMA