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Common stonecrop herb and use of salidroside in stem cell committed differentiation to hepatocyte lineage

A technology of directed differentiation and salidroside, applied in the field of rhodiola

Active Publication Date: 2008-07-23
北京瑞草堂三圣(汤阴)药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] At present, there is no report that rhodiola and salidroside can induce the directed differentiation of adult stem cells into hepatic cells

Method used

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  • Common stonecrop herb and use of salidroside in stem cell committed differentiation to hepatocyte lineage
  • Common stonecrop herb and use of salidroside in stem cell committed differentiation to hepatocyte lineage
  • Common stonecrop herb and use of salidroside in stem cell committed differentiation to hepatocyte lineage

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Experimental program
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Effect test

Embodiment 1

[0047] Reagents and materials:

[0048] 4-week-old SD rats: Experimental Animal Center of Zhejiang Academy of Medical Sciences;

[0049] Salidroside and salidroside aglycon: China National Institute for the Control of Pharmaceutical and Biological Products;

[0050] Percoll: Pharmacia;

[0051] Low-sugar DMEM medium: GIBCO company;

[0052] High-glucose DMEM medium: GIBCO company;

[0053] Fetal bovine serum: GIBCO company;

[0054] Hepes (2-[4-(2-hydroxyethyl)-1-piperazine]ethanesulfonic acid): Amresco Company;

[0055] Insulin / transferrin / selenium: Sigma;

[0056] Dexamethasone: Sigma;

[0057] HGF: Pepro Tech;

[0058] FGF-4: Pepro Tech.

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Abstract

The invention relates to a rhodiola rosea and a rhodioside application for inducing stem cells to directionally differentiate into hepatocytes, in particular to a compound inducer of the rhodioside and cell growth factor FGF-4 used for inducing mesenchymal stem cells to directionally differentiate into hepatocytes. The rhodiola rosea develops the new application of rhodiola, which induces mesenchymal stem cells and other stem cells to directionally differentiate into hepatocytes in vitro, and provides the effect of the rhodiola rosea and the rhodioside on inducing the adult stem cells to directionally differentiate into hepatocytes, which is beneficial to further research of the in vivo stem cells transplantation for treating acute or chronic hepatic injury and middle-advanced liver disease field, and provides the basic for new drug development.

Description

(1) Technical field [0001] The invention relates to the application of rhodiola rosea, especially salidroside, in inducing stem cells to differentiate into hepatic cells. (2) Background technology [0002] Rhodiola is a plant of the genus Rhodiola (Rhodiola L.) of the Crassulaceae family. It is a perennial herb or subshrub plant, mainly distributed in the Himalayas in the northern hemisphere, northwest Asia and North America at an altitude of 1,600 to 4,000 meters. area. Rhodiola rosea has a long history of medicinal use, known as "golden ginseng" and "immortal grass". According to the Pharmacopoeia, Rhodiola rosea is the dry root and rhizome of Rhodiola grandiflora of the sedum family plant. It is sweet, bitter, and flat in nature. Burnout and shortness of breath. Modern pharmacological research shows that the biological activity of rhodiola rosea is inseparable from its various chemical components. [0003] Salidroside (salidroside) is a natural product isolated and pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/06A61K36/41A61P1/16C12N5/071C12N5/0775
Inventor 李连达欧阳竞锋吴理茂乔洪翔
Owner 北京瑞草堂三圣(汤阴)药业有限公司
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