Method for preparing taurine

A technology of taurine and isethionic acid, applied in the direction of organic chemistry, etc., can solve the problems of harsh production environment, excessive soda ash, decomposition of taurine, etc., to reduce power consumption and labor consumption, good production environment, The effect of improving the reaction yield

Inactive Publication Date: 2008-09-10
常熟市虞东化工有限公司 +1
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Problems solved by technology

[0042] This method is difficult to control in the actual production process, it is difficult to accurately measure the pH value, and it is easy to add too much soda ash. What is more complicated is the separation of taurine and sodium sulfate. Separation of taurine and sodium sulfate (glauber's salt) at low temperature, accompanied by a large amount of SO 2 gas, making the production environment extremely harsh
[0043] This process also has many heating and cooling steps in the water phase and takes a long time, which will cause taurine to decompose and cause side reactions.
In addition, a large amount of taurine is entrained during the removal of sodium sulfate, and the loss rate is large

Method used

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  • Method for preparing taurine
  • Method for preparing taurine

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Experimental program
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Embodiment 1

[0055] At 30° C., 78 g (1 mol) of hydroxyethyl mercaptan and 1133 g of 12% hydrogen peroxide (4 mol) were added to a 2000 mL autoclave, and the reaction was stirred for 3 hours after sealing. After the reaction, an isethionic acid solution was obtained.

[0056] Add 11mol ammonia to the isethionic acid solution obtained above (containing 1mol isethionic acid), add the solution to the pressure reactor, react at 260 degrees for 5 hours, drop to room temperature, and dropwise add hydrochloric acid to the precipitation. The solid was filtered and dried to obtain 100.2 g of taurine.

Embodiment 2

[0058] At 25°C, 78g (1mol) of hydroxyethyl mercaptan and 342g (4.5mol) of peracetic acid were added to a 2000mL autoclave, 1000mL of water was added, and the reaction was stirred for 6 hours after sealing. After the reaction, an isethionic acid solution was obtained.

[0059] Add 15mol ammonia to the isethionic acid solution obtained above (containing 1mol isethionic acid), add the solution to the pressure reactor, at 280 degrees, react for 3 hours, drop to room temperature, and dropwise add hydrochloric acid until it separates out. The solid was filtered and dried to obtain 105.6 g of taurine.

Embodiment 3

[0061] Under 20 ℃, in 2000mL autoclave, add the peroxybenzoic acid of 78g (1mol) hydroxyethyl mercaptan and 753g (5.5mol), add 700mL water and 50mL DMF, stir and react 8 hours after sealing, get hydroxyethyl alcohol after the reaction finishes. sulfonic acid solution.

[0062] Add 19mol ammonia to the isethionic acid solution obtained above (containing 1mol isethionic acid), add the solution to the pressure reactor, react at 300 degrees for 2 hours, drop to room temperature, and dropwise add hydrochloric acid to the precipitation. The solid was filtered and dried to obtain 101.2 g of taurine.

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Abstract

The invention discloses a preparation method for taurine which comprises the following steps that: 1. ethylene thioglycol is oxidized by oxidizer in the solvent to prepare hydroxyethylsulfonate; 2. the hydroxyethylsulfonate is reacted with ammonia to prepare taurine. The preparation method for taurine of the invention has short process route and low cost. The first-step oxidation reaction has mild conditions, can be made at normal temperature and has low energy consumption. The total reaction process has no waste liquid and waste residue, and no escape of sulfur dioxide gas, so the production environment is good. Compared with the prior commonly used method, the preparation method is more clean, can reduce large power consumption and manpower consumption, and the reaction yield can be improved by 20 percent compared with the general process.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a preparation method of taurine. Background technique [0002] Taurine, also known as taurine, is a sulfur-containing non-protein amino acid whose chemical name is 2-aminoethanesulfonic acid. It is also more and more widely, and has important applications in medicine, food, fuel, surfactant, pH buffer, etc. As a drug, taurine can be used for choleretic, hepatoprotective, detoxification, anti-inflammatory, antipyretic, sedative, anticonvulsant, antiarrhythmic, treatment of cardiac insufficiency, regulation of osmotic pressure, lowering blood pressure, treatment of arteriosclerosis, inhibition of central nervous system, maintenance of vision, etc. At present, some developed countries in the world, such as the United States and Japan, have added an appropriate amount of taurine to the milk and milk powder for infants to ensure the health and normal d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/14
Inventor 刘遗松徐斌钱继新邵学青赵国宏陆继东
Owner 常熟市虞东化工有限公司
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