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Method for partially oxidizing sodium alginate

A technology for oxidizing sodium alginate and sodium alginate, which is applied in the field of biomedical materials, can solve the problems of excessive hydrophilicity, lack of cell recognition sites, and high price of sodium periodate, and achieves that the method is simple, easy to control, and easy to popularize. The effect of application, easy availability of raw materials

Inactive Publication Date: 2008-09-10
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are two disadvantages when alginate hydrogel is used in biomedical materials: (1) alginate degrades slowly in vivo, and the degradation product is relatively large; (2) too strong hydrophilicity hinders Adsorption of protein components while lacking cellular recognition sites
The modification methods mainly include physical blending modification method and chemical modification method, among which the currently known chemical modification method only uses sodium periodate as an oxidant to partially oxidize sodium alginate, but this method has no The control of the degree of oxidation is not easy, and the price of sodium periodate is relatively high, so it has not been widely used

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Examples

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Effect test

Embodiment 1

[0025] Weigh 1 g of sodium alginate and add it to 100 ml of deionized water, and stir magnetically until the sodium alginate is completely dissolved to obtain a 1% (w / v) sodium alginate solution. Weigh 1.5878g of potassium permanganate and put it in 100ml of distilled water, stir and boil. After the potassium permanganate is fully dissolved, let it stand in the dark for 6 days, and finally take the upper clear solution for calibration. The concentration of the potassium permanganate solution is 0.1227mol / L, stored in a brown bottle for later use. Add dropwise 0.5 ml of (1:5) aqueous sulfuric acid solution to the sodium alginate solution to adjust the pH value to 4, and stir the solution sufficiently. Then accurately measure 1.5ml of the above potassium permanganate solution and add it to the sodium alginate solution, stir and react at room temperature in the dark, and stop the oxidation reaction when the solution becomes colorless. In the solution after reaction, add 0.30g s...

Embodiment 2

[0027] Weigh 1 g of sodium alginate and add it to 100 ml of deionized water, and stir magnetically until the sodium alginate is completely dissolved to obtain a 1% (w / v) sodium alginate solution. Weigh 2.3756g of potassium permanganate and place it in 100ml of distilled water, stir and boil. After the potassium permanganate is fully dissolved, let it stand in the dark for 8 days. Finally, take the upper clear solution for calibration. The concentration of the potassium permanganate solution is 0.1671mol / L, stored in a brown bottle for later use. Add dropwise 0.5 ml of (1:5) aqueous sulfuric acid solution to the sodium alginate solution to adjust the pH value to 4, and stir the solution sufficiently. Then accurately measure 1.0ml of the above potassium permanganate solution and add it to the sodium alginate solution, stir and react at room temperature in the dark, and stop the oxidation reaction when the solution becomes colorless. In the solution after reaction, add 0.30g so...

Embodiment 3

[0029] Weigh 1 g of sodium alginate and add it to 100 ml of deionized water, and stir magnetically until the sodium alginate is completely dissolved to obtain a 1% (w / v) sodium alginate solution. Weigh 1.2683g of potassium permanganate and put it in 100ml of distilled water, stir and boil it. After the potassium permanganate is fully dissolved, let it stand in the dark for 4 days, and finally take the upper clear solution for calibration. The concentration of the potassium permanganate solution is 0.0848mol / L, stored in a brown bottle for later use. 0.3 ml of sulfuric acid aqueous solution (1:5) concentration was added dropwise to the sodium alginate solution to adjust the pH value to 3.5, and the solution was fully stirred. Then accurately measure 0.5ml of the above potassium permanganate solution and add it to the sodium alginate solution, stir and react at room temperature in the dark, and stop the oxidation reaction when the solution becomes colorless. Add 0.30g sodium c...

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Abstract

The invention discloses a method for partially oxidizing sodium alginate. The steps of the method are as follows: 1) a sodium alginate solution is prepared; 2) a potassium permanganate solution is prepared; 3) the pH value of the sodium alginate solution is adjusted by an acid solution; 4) the potassium permanganate solution is added to the sodium alginate solution and stirred for reaction under conditions of room temperature and light prevention; the oxidizing reaction stops when the mixed solution is colorless; 5) the solution after reaction is added with sodium chloride and then added with ethanol so as to separate precipitation out of the filtrate, and coarse products are obtained after decompression and pumping filtration; 6) the coarse products are dissolved in water and dialyzed; 7) after the complete dialysis, dialyzate is pre-freezed and then freeze-dried, and finally partially oxidizing sodium alginate products are obtained. The method has the advantages of simple and easy control of process, easy collection of raw materials, low cost and convenient popularization and application; the partially oxidizing sodium alginate prepared can be used to degrade gel materials, drug slow release materials, biological carrier materials and tissue engineering materials, etc.

Description

technical field [0001] The invention relates to a partial oxidation method of sodium alginate, which is applied to biomedical materials. Background technique [0002] Sodium alginate is a natural polysaccharide polymer extracted from brown algae, which has the characteristics of good biocompatibility, low toxicity and abundant resources. In the presence of divalent ions, sodium alginate can form alginate gel through ionic cross-linking reaction, which is widely used in biomedical materials and other fields. However, there are two disadvantages when alginate hydrogel is used in biomedical materials: (1) alginate degrades slowly in vivo, and the degradation product is relatively large; (2) too strong hydrophilicity hinders Adsorption of protein components, while lacking cell recognition sites. In order to make sodium alginate meet the application requirements in the field of biomedical materials, it is often necessary to modify it. The modification methods mainly include ph...

Claims

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Application Information

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IPC IPC(8): C08B37/04
Inventor 卢凌彬张苹曹阳庞素娟林强王华明
Owner HAINAN UNIVERSITY
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