Compound glycyrrhizin dispersible tablet and preparation method thereof

A technology of compound glycyrrhizin and monoammonium glycyrrhizinate, which is applied in the field of medicine, can solve the problems of reduced therapeutic effect, low patient medication compliance, and inconvenient medication, and achieve the effects of reducing electrolyte metabolism abnormalities, convenient treatment, and tight packaging

Inactive Publication Date: 2008-10-22
孙向阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the compound glycyrrhizinate injection is mainly on the market. The existing problems are that it is inconvenient to use the drug, and the patient’s medication compliance is low. It is difficult for chronic patients, especially those with hepatitis, to adhere to long-term injection medication, which often leads to a decrease in the therapeutic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Monoammonium Glycyrrhizinate 35g

[0051] Glycine 25g

[0052] Methionine 25g

[0053] Crospovidone 60g

[0054] Hypromellose 40g

[0055] Microcrystalline cellulose (added inside) 120g

[0056] 5% Povidone K 30 50% ethanol solution appropriate amount

[0057] Microcrystalline cellulose (extra) 40g

[0058] Carboxymethyl Starch Sodium 24g

[0059] Silica 12g

[0060] Magnesium Stearate 4g

[0061] Weigh monoammonium glycyrrhizinate, glycine, methionine, microcrystalline cellulose, crospovidone, and hydroxypropyl cellulose according to the above table, and place these raw and auxiliary materials in a mixer and mix them uniformly; 5% Povidone K 30Add 50% ethanol solution into the mixture of raw and auxiliary materials and stir to make a suitable soft material; use a 30-mesh sieve in a swing granulator to make the soft material into wet granules; dry the wet granules at 60°C for 4 hours, Then the dry granules are granulated through a 20 mesh sieve; the carboxyme...

Embodiment 2

[0063] Monoammonium Glycyrrhizinate 70g

[0064] Glycine 50g

[0065] Methionine 50g

[0066] Crospovidone 120g

[0067] Hypromellose 80g

[0068] Microcrystalline cellulose (added inside) 240g

[0069] 5% Povidone K 30 50% ethanol solution appropriate amount

[0070] Microcrystalline cellulose (extra) 80g

[0071] Carboxymethyl Starch Sodium 48g

[0072] Silica 24g

[0073] Magnesium stearate 8g

[0074] Weigh monoammonium glycyrrhizinate, glycine, methionine, microcrystalline cellulose, crospovidone, and hydroxypropyl cellulose according to the above table, and place these raw and auxiliary materials in a mixer and mix them uniformly; 5% Povidone K 30 Add 50% ethanol solution into the mixture of raw and auxiliary materials and stir to make a suitable soft material; use a 30-mesh sieve in a swing granulator to make the soft material into wet granules; dry the wet granules at 60°C for 4 hours, Then the dry granules are granulated through a 20 mesh sieve; the carbo...

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PUM

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Abstract

The invention pertains to the field of medicine and provides a compound glycyrrhizin dispersible tablet and a preparation method thereof, the compound glycyrrhizin dispersible tablet contains the components with the following weight percentages: 5 to 15 percent of monoammonium glycyrrhizinate, 3.5 to 10 percent of glycin, 3.5 to 10 percent of methionine, 10 to 20 percent of cross-linking PVP, 5 to 15 percent of hydroxypropyl cellulose, 35 to 45 percent of microcrystalline cellulose, 4 to 8 percent of sodium starch glycolate, 2 to 4 percent of silicon dioxide, 0.5 to 1.5 percent of magnesium stearate and 0.5 to 1.5 percent of polyvinylpyrrolidone K30. The dispersible tablet provided by the invention has the advantages of good absorption, convenient administration, high bioavailability, convenient usage, long-term combined usage, simple preparation method and so on.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a compound glycyrrhizin dispersible tablet and a preparation method thereof. Background technique [0002] The intravenous and oral preparations with glycyrrhizic acid as the main component were first developed in Japan in 1948. Because of its anti-allergic and anti-inflammatory effects, it was mainly used in the field of dermatology to treat a variety of allergic skin diseases. It was approved in 1958. Trial for the treatment of chronic hepatitis, the liver function index has been significantly improved; in 1977, Japanese liver disease experts used a strict randomized double-blind control method to verify the curative effect of compound glycyrrhizin on chronic hepatitis, and confirmed its effect on chronic hepatitis. The exact curative effect of hepatitis; in 2002, Hiromitsu Kumata reported the long-term curative effect of compound glycyrrhizin on hepatitis C. Since the compound glycyrrh...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/704A61K47/16A61P1/16
Inventor 孙向阳
Owner 孙向阳
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