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Xanthophyll micro-capsule and its preparation method

A technology of lutein and microcapsules, which is applied in the field of microcapsule preparation, can solve the problems of instability, limited use, storage, transportation and easy failure of use, etc.

Inactive Publication Date: 2010-06-02
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although lutein is widely used in many fields, due to its instability, it is prone to failure during storage, transportation and use, which limits its use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] The preparation method of the above-mentioned lutein microcapsules is prepared by a composite coacervation method, and the steps are as follows:

[0018] (1) Dissolve lutein or lutein extract in an organic solvent at room temperature to make a 0.3-0.6g / mL lutein solution for later use.

[0019] (2) prepare the acetic acid solution of chitosan, the mass concentration of chitosan is 0.5%-3%wt, the mass ratio of chitosan and acetic acid is 0.5-3: 1, or gelatin is dissolved in hot water and the preparation concentration is 1%-4% wt gelatin solution; dissolving gum arabic in water to prepare a 1%-6% wt gelatin solution for later use.

[0020] (3) Add an emulsifier to the gum arabic solution and stir evenly, then add the lutein solution in step (1), add an antioxidant, and then homogenize the mixed solution into a uniform emulsion with a homogenizing machine.

[0021] (4) Add the gum arabic solution homogeneously emulsified in step (3) into the chitosan acetic acid solution ...

Embodiment 1

[0033] Dissolve 1g of chitosan in 50mL of 1% acetic acid solution at room temperature to prepare a 2% chitosan-acetic acid solution; dissolve 2g of gum arabic in 50mL of water to prepare a 4% aqueous solution of gum arabic, and add Stir and dissolve 2mL Tween-80, add 1g lutein, emulsify homogeneously at 8000rpm for 10min; pour the emulsified emulsion into the chitosan solution, coagulate at 60°C, adjust the pH to 4.5, stir for 30min, add 100mL 60°C water Dilute, stop heating, lower the temperature to room temperature, add 4 mL of 25% glutaraldehyde to solidify for 1 h; adjust the pH value of the system to 7, and continue stirring for 30 min; then stop stirring, settle, and wash the microcapsules with distilled water until the upper layer is clear. Add 3g of magnesium stearate therein, stir to make it uniformly mix with the microcapsules, filter, vacuum-dry, put the dry matter into water and stir to remove the magnesium stearate, filter to obtain dry microcapsules. Microcapsule...

Embodiment 2

[0035] Dissolve 1g of chitosan in 50mL of 1% acetic acid solution at room temperature to prepare a 2% chitosan-acetic acid solution, add 0.1g of vitamin C thereto; dissolve 3g of gum arabic in 50mL of water to prepare a 6% gum arabic solution Solution, add 2mL Tween-80 to the gum arabic solution and stir to dissolve, add 1g lutein, and emulsify at 8000rpm for 10min; pour the emulsified emulsion into the chitosan solution, coagulate at 60°C, adjust the pH to 4.5, Stir for 30min, add 100mL of 60°C water to dilute, stop heating, let the temperature drop to room temperature, add 4mL of 25% glutaraldehyde to solidify for 1h; adjust the pH value of the system to 7, continue stirring for 30min; Capsules, until the upper liquid is clear, add 4g of magnesium stearate to it, stir to make it evenly mixed with the microcapsules, filter, vacuum dry, put the dry matter into water and stir to remove the magnesium stearate, filter to obtain dry microcapsules . Microcapsules with an average p...

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PUM

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Abstract

The invention relates to a xanthophylls microcapsule and a preparation method thereof. The core material of the microcapsule is xanthophylls and the wall material is natural macromolecule chitosan orglutin, gum acacia and antioxidant. The technique has the following steps: the xanthophylls is dissolved in an organic solvent, which is added into a gum acacia solution containing emulsifier and antioxidant for uniform emulsion; the well emulsified gum acacia is added into the chitosan or glutin solution for being condensed into capsules, and the capsules are processed with magnesium stearate after solidification; the microcapsules with excellent dispersivity are obtained after drying. The microcapsule prepared by the technique has the grain diameter of 1-200 Mum. The preparation technique has simple process, mild preparation condition and easy popularization; the microcapsule prepared has good dispersivity and high stability and is suitable for industries such as food, health care products, feed, etc.

Description

technical field [0001] The invention relates to a microcapsule preparation process, in particular to a lutein microcapsule prepared by a composite coacervation method and a preparation method thereof. Background technique [0002] Lutein belongs to carotenoid, which is a kind of natural pigment. It has bright color, strong tinting power, good anti-oxidation, safe and non-toxic, and has rich nutritional value. It is a natural substance that widely exists in vegetables, flowers, fruits and some algae plants, and is widely used in many fields such as food, health care products, cosmetics, medicine, tobacco and animal and poultry feed, see Wang Mingchen et al. Antioxidant activity, mutagenicity / antimutagenicity and decomposition / anti-decomposition of lutein extracted from marigolds", Food and Chemical Toxicology, 2006, 44: 1522-1529 (Mingchen Wang, Rong Tsao, Shanfeng Zhang, et al. Antioxidant activity, mutagenicity / anti-mutagenicity, and clastogenicity / anti-clastogenicity of l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/047A61K9/50A61K47/30A61P39/06
Inventor 隋卫平黄亮亮
Owner UNIV OF JINAN
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