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Preparation technique of alkaloids from Stephania tetrandra

A preparation process, the technology of Fangji, which is applied in the field of preparation of Fangji alkaloids, can solve the problems of difficult recovery of alkaloids, cumbersome operation steps, and reduced extraction rate, and achieve the effects of saving manpower, high extraction rate, and reducing pollution discharge

Inactive Publication Date: 2008-10-22
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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Problems solved by technology

Method 1 produces a large amount of waste water, tetrandrine is difficult to completely precipitate and the extraction rate is reduced, and water-soluble alkaloids are difficult to recover
Method 2 has a large solvent loss and high cost
Both methods have the disadvantage of cumbersome operation steps

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  • Preparation technique of alkaloids from Stephania tetrandra

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Abstract

The invention belongs to the chemistry of natural product field, which more particularly relates to a preparation technique of tetrandrine alkaloid. Dilute acid solution is used for percolating tetrandrine meal, leachate is absorbed by macroporous resin column, after being washed, alcohol solution with ammonia / amine is used for eluting, and then total alkaloids is get by concentration, finally tetrandrine alkaloid with high purity is obtained by crystallization. The tetrandrine alkaloid has the advantages of easy operation, less hazardous waste and residue, low cost, high yield, and getting all the tetrandrine alkaloid for once, etc. The method is a simple, economic, fast and strong practical processing method which comprehensively utilizes the tetrandrine alkaloid.

Description

Preparation technology of tetrandrine alkaloid technical field The invention belongs to the field of natural product chemistry, and in particular relates to a preparation process of tetrandrine alkaloids. Background technique Fangji has another name called powder Fangji, Han Fangji, and stone toad, which is the dry root of the perennial twining vine of Fangjiaceae, Stephaniatetrandra S. Moore. Bitter in the mouth, it has the effect of diuresis, detumescence, dispelling wind and relieving pain. For edema beriberi, dysuria, eczema sores, rheumatic arthralgia and hypertension (Pharmacopoeia of the People's Republic of China 2005 edition one, P101-102). Modern studies have found that Tetradendron alkaloids have various pharmacological effects such as antiarrhythmia, antimyocardial, cerebral, and renal ischemia, antihypertension, anti-inflammation, and anti-tumor multidrug resistance (Chinese Journal of Pharmaceutical Sciences, 2000, 35, P800 -802). Alkaloids are mainly tetr...

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Application Information

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IPC IPC(8): A61K36/59A61P9/00A61P29/00A61P35/00A61K125/00
Inventor 王明奎崔文峰鲍玲李甫
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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