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Beta-carotene microcapsule and preparing method thereof

A technology of carotene and capsule material, which is applied in the field of health care products and pharmaceuticals, can solve the problems of limited dissolution, difficulty, and low drug content in products, and achieve the effects of enhanced stability and water solubility, good water solubility and coloring ability

Inactive Publication Date: 2008-10-29
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the above-mentioned patents and documents and documents not listed in this patent, the preparation of microcapsules by single coacervation or complex coacervation or spray drying requires the use of cross-linking curing agents or organic solvents with low solubility, while the two-phase emulsification spray drying method , due to the limited solubility of β-carotene by organic solvents, it is difficult to prepare a higher content of two-phase emulsion by adding an organic solvent as the oil phase, and the final product has a lower drug content or does not dissolve well completely
Among them, the two patents of BASF Company adopt the protective colloid method, which is also a microencapsulation method, but it also needs to use organic solvents, use isopropanol, and need to perform homogenization and other operations at a high temperature of 170 ° C, which requires relatively high equipment requirements. High, there is a certain risk, and there may be solvent residues

Method used

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  • Beta-carotene microcapsule and preparing method thereof
  • Beta-carotene microcapsule and preparing method thereof
  • Beta-carotene microcapsule and preparing method thereof

Examples

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Effect test

Embodiment 1

[0022] The lycopene microcapsules of the present invention are composed of the following raw materials in weight ratio:

[0023] Zeaxanthin: monoglyceride: gelatin: phospholipid: water = 1:3:3:2:90.

[0024] Its preparation method is as follows:

[0025] Take 10g of zeaxanthin and 30g of monoglyceride according to the above weight ratio, mix evenly, heat to 200°C to melt, cool, and form the oil phase; according to the above weight ratio, take 30g of gelatin, 20g of phospholipid and soak in water for 2 hours to form the water phase; The oil phase is melted at 70-80°C and mixed with the water phase, homogenized in a high-pressure homogenizer, the homogenization pressure is 100Ma, and circulated for 3 times, discharged, and spray-dried to obtain zeaxanthin microcapsules.

Embodiment 2

[0027] The lycopene microcapsules of the present invention are composed of the following raw materials in weight ratio:

[0028] Lycopene: tripalmitin: isinglass: sucrose: sucrose lipid: water = 1:5:6:2:5:80.

[0029] Take 10g of lycopene and 50g of tripalmitin according to the above weight ratio, heat to 100°C to melt, quickly pour it on a steel plate to cool, and crush it to form an oil phase; dissolve isinglass, sucrose, and sucrose ester in water to form a water Mutually. The oil phase and the water phase are mixed at 50-70°C, homogenized by micro-jet, discharged, and spray-dried to obtain the finished product.

Embodiment 3

[0031] Astaxanthin microcapsules of the present invention are composed of the following raw materials in weight ratio:

[0032] Astaxanthin: trilaurin: casein: Tween 20: water = 1:10:15:1:80.

[0033] Take 10g of astaxanthin and 100g of glyceryl trilaurate according to the above weight ratio and heat to 180°C to melt, then cool rapidly to room temperature to form an oil phase, dissolve casein and Tween 20 in water to form an aqueous phase; Mix with the oil phase at 70-80°C, and perform high-shear homogenization to obtain the material, which is then freeze-dried to obtain the finished product.

[0034] Tween 20 described in this example can be replaced by Tween 80, Tween 60 or any mixture thereof.

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Abstract

The invention discloses a beta-carotene micro-capsule and the preparation method thereof. The beta-carotene comprises one of lycopene, lutein, zeaxanthin and astaxanthin or the mixture thereof, belonging to the fields of drugs and health care products. The beta-carotene micro-capsule is composed of the following raw materials by weight proportions: beta-carotene: lipid material: capsule material: emulsifier: water equals to 1:1-20:1-20-1-10:80-100. The invention adopts a two-phase emulsion spray drying method to prepare the beta-carotene micro-capsule, which has good light and thermal stability and water-solubility or water dispersivity.

Description

technical field [0001] The invention relates to a beta-carotene microcapsule and a preparation method thereof, belonging to the field of medicines and health care products. Background technique [0002] β-carotene includes two types of compounds, one is carotene and lutein, carotene includes β-carotene and lycopene, lutein includes lutein, astaxanthin, and zeaxanthin. Carotenoids widely exist in nature and are the color components of many organisms. Recent studies have found that carotenoids have important physiological functions for the human body. For example, β-carotene is the precursor of VA, which can be converted into VA in the human body. Lutein and zeaxanthin have unique physiological functions in protecting vision, preventing cardiovascular disease and cancer, and enhancing immunity. Lycopene and astaxanthin have strong antioxidant effects in preventing free radicals from invading biofilms, quenching singlet oxygen and capturing active oxygen free radicals. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K31/015A61K31/045A61K31/122A61K9/50A61K47/10A61K47/12A61K47/14A61K47/34A61K47/36A61K47/38A61K47/42A61P3/02A61P39/06
Inventor 董英杰艾莉
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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