Preparation of stable water-soluble carotenoid dry powder

A carotene and water-soluble technology, which is applied in the field of preparation of nano-sized water-soluble carotenoid dry powder, can solve problems such as unsatisfactory, inconvenient storage and transportation, complicated preparation methods and processes, etc.

Inactive Publication Date: 2008-11-05
CHENGDU CANFO CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These documents have announced the method that can prepare the carotenoid substance particle of nano-scale particle size, but its finished product aqueous solution is often in the form of emulsion, and it is also inconvenient to store and transport
[0005] The publication number applied by BASF company is CN1348483A "The stable water dispersion of lutein and the stable water dispersible dry powder and its preparation and application", the formed dry powder can be dispersed in water to form a transparent powder with an average particle diameter of 129nm. Dispersion, but the preparation process requires a higher temperature (> 170 ° C), because the solvent used is isopropanol and other systems, so it needs to use high-pressure resistant equipment, the production is difficult and the process is more complicated
Publication No. CN101143132 provides "a kind of preparation method of water-soluble nanoparticles with high β-carotene content", which adopts vegetable oil solution, n-hexane or cyclohexane solution and emulsifier through high-pressure homogenization, and further Freeze-drying with volatile solvents can obtain β-carotene water-soluble nanoparticles freeze-dried powder, and the preparation method and process are still relatively complicated and unsatisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dissolve 10 g of lutein in 1200 ml of isopropanol at 65°C to prepare an organic solution phase; mix 0.5 g of xanthan gum, 20 g of Tween 80, 23 g of gum arabic, 12 g of β cyclodextrin, 0.1 g CMC sodium is dissolved in 1000 ml of water to make an aqueous phase, and the organic phase solution is added to the aqueous phase under high-speed stirring at 3000-5000 rpm, and the stirring is continued for 2 hours to fully disperse and mix. After the organic solvent was evaporated under reduced pressure, 25 g of water-soluble starch, 5 g of sucrose, and 5 g of sodium caseinate were added, stirred uniformly, and spray-dried to obtain the corresponding water-soluble lutein powder product. Dissolve the powder product in cold water to form a transparent yellow solution of 0.1% aqueous solution, with an average particle size of 162nm. After a 20-minute centrifugation test at 2000 rpm, no precipitation or suspended matter appeared; it was still uniform and no precipitation after being place...

Embodiment 2

[0020] After dissolving 10 grams of lycopene in 600ml acetone at 50℃, add it to 1000ml aqueous solution containing 15 grams of Tween, 30 grams of gum arabic, 5 grams of peach gum, and 5 grams of PVP at 11000 revolutions per minute. Stir at high speed for 2 hours to fully disperse and mix. Add 3 grams of β-cyclodextrin, 10 grams of sucrose and 30 grams of prime dextrin to the remaining liquid after steaming the organic solvent, stir evenly, and spray-dry to obtain a deep red powder product. The product powder is dissolved in water to prepare a 0.1% red transparent solution with an average particle size of 95nm. After a 10 minute centrifugation test at 3000 rpm, there was no precipitation and suspended matter, and there was no change after 60 days at room temperature.

Embodiment 3

[0022] Dissolve 10 grams of astaxanthin in 1000 ml of acetone at 50°C. Add this solution to 1000 ml of aqueous solution containing 10 grams of sucrose esters, 10 grams of S-40, 15 grams of gum arabic and 10 grams of β-cyclodextrin. Stir at high speed at 8000-10000 rpm for 2 hours and mix well. Add 40 grams of oxidized starch, 100 ml of 1% xanthan gum aqueous solution and 10 grams of pullulan to the residue after steaming the acetone solvent, stir evenly, and spray-dry to obtain a red powder product. The powder product was dissolved in water to form a red transparent solution, and the average particle size was determined to be 131 nm. The solution was centrifuged at 3000 rpm for 10 minutes without change; it remained unchanged at room temperature for 90 days.

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Abstract

The invention relates to a preparation method for stable water soluble carotenoid dry powder, the organic solvent of acetone or isopropanol dissolved with carotenoid component is added into an aqueous phase solvent containing a surfactant and adjuvant-stabilization component to be sufficiently mixed under sufficient stirring, then the organic solvent in the mixed solvent is removed and an auxiliary forming accessory which is one to twelve times of the carotenoid component by mass is added to be evenly stirred and treated with sponging frying to obtain the powder product. The preparation method is simple and easy, complex operation such as high pressure homogenization is not needed, and the procedures are less, therefore, the method is applicable to various carotenoid components containing Beta-carotene, astaxanthin, lutein, corn pigment and lycopene, etc. The method has the advantages that the performance of the products is good, the grain diameter of the powder product can be in the range of 90 to 170 nm, and the product can be evenly dispersed in water and form a stable and transparent carotenoid water dispersoid solvent.

Description

Technical field [0001] The invention relates to a method for preparing high-stability nanometer water-soluble carotenoid dry powder. Background technique [0002] Carotenoids are extremely difficult to dissolve in water, which greatly limits their application in various liquid products such as beverages, oral liquids, medicinal or feed use, and liquid preparations. [0003] For this reason, most commonly used methods are to increase its water solubility through emulsification or microencapsulation. For example, the Chinese patent document with publication number CN1757315A discloses a "water-soluble lutein", the Chinese patent document with publication number CN101032683A discloses a "lutein microcapsule and its preparation method", and CN101015342 discloses a "lycopene" CN1081333 discloses a “natural β-carotene aqueous solution and its preparations”, CN1623983 discloses a “method for preparing water-soluble β-carotene dry powder using fat-soluble β-carotene and Application" etc....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/275A61K8/31A61Q1/02A23L5/42
Inventor 陈思成
Owner CHENGDU CANFO CHEM
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