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Special glue for producing algal polysaccharides plant capsules

A seaweed polysaccharide and plant capsule technology, which is applied in the directions of capsule delivery, medical preparations with non-active ingredients, and pharmaceutical formulations, can solve problems such as incomplete grasp of physical and chemical properties, inability to meet product standard requirements for hard-shell hollow capsules, and the like. The effect of convenient control of raw materials, low cost and simple production process

Inactive Publication Date: 2008-11-05
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some manufacturers declare that their products are plant capsules, the applicant found that these products cannot meet the national standard requirements for hard-shell hollow capsule products.
[0009] One of the root causes of the above-mentioned problems is that the physical and chemical properties of the raw materials for the production of plant capsules are not fully grasped, and the raw materials for the production of plant capsules cannot be well selected, that is, there is no mature reasonable formula for plant capsule special glue in our country.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] When the number of parts of water is 100, the required weight ratio of various substances is: 8 kg of cellulose with a viscosity of 10 centipoise (viscosity at 20°C) dissolved in 70 kg of 30°C warm water After fully stirring and dissolving evenly, add 2 kg of seaweed polysaccharide as a coagulant and heat to 70 degrees while stirring, and then add 2 ml of 0.5% calcium citrate as a coagulant after the two substances are fully dissolved. Dissolve 3 kg of hydrolyzed starch and 30 kg of water, mix with the above solution and heat it in a water bath to 70 degrees, keep it for at least 2 hours to make all the substances reach the reaction equilibrium, and then immerse the capsule template in it for 5 seconds at a temperature of 45 degrees , After taking it out, dry it in a 35-degree drying tunnel, and then perform pilling and film removal. The hollow capsule prepared according to the formula provided in this example has a thickness of about 10 filaments, which meets the natio...

Embodiment 2

[0043] According to the weight of various substances when the number of water is 100: take 10 kg of cellulose hydroxypropyl methyl ether with a viscosity of 10 centipoise (viscosity at 20°C), mix them with 3 kg of seaweed polysaccharide and dissolve them in 80 Add 5ml of 0.5% calcium ion as a coagulant in kilograms of 70°C hot water, fully stir and dissolve evenly. Add 2 kg of hydrolyzed starch to 20 kg of water to dissolve, mix with the above solution, and heat the water bath to 70 degrees. The equilibrium reaction time is kept for at least 2 hours, and the capsule template is immersed in it for 3-4 seconds at a temperature of 48 degrees. Take it out Finally, it is dried in a drying tunnel at 35 degrees, and then the pellets are pulled out to remove the film. The hollow capsules prepared according to the formula provided in this example have a thickness of about 9-10 filaments, meeting the national standard for gastric dissolution within 10 minutes.

Embodiment 3

[0045] According to the weight of various substances when the number of water is 100: take 7 kg of gum arabic and 3 kg of seaweed polysaccharide and dissolve them in 70 kg of water, heat to 75 degrees, stir well for about 1 hour, add 10 ml of 1.0% citric acid Potassium solution is used as a coagulant aid, and it is stirred evenly again. After adding 3 kg of maltodextrin and dissolving it with 30 kg of water, the above solutions are combined and heated to 50°C. After maintaining the reaction equilibrium time for 2 hours, keep the temperature at 45 degrees, immerse the capsule template in it for 3-4 seconds, take it out and dry it in a dryer at 35 degrees, and then pull out the pill and remove the film.

[0046]The hollow capsules prepared according to the formula provided in this example have a thickness of about 9-10 filaments, meeting the national standard for gastric dissolution within 10 minutes.

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PUM

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Abstract

The invention relates to seaweed chemistry and empty capsules, in particular to a special gum used for producing seaweed polysaccharide plant capsules, comprising a film-forming agent, a filming aid, water, a colloid with thermal reversibility and a coagulant aid. The proportions of the components are calculated by weight: when the water is 100 portions, cellulose hydroxy propyl methyl ether, locust bean gum or acacia is selected as the film-forming agent which is 7 to 15 portions; algal polysaccharides is selected as the filming aid which is 1 to 5 portions; hydrolyzed starch or maltodextrin is selected as the colloid with thermal reversibility which is 1 to 10 portions; dissoluble sylivine or calcium salt is selected as the coagulant aid and when 7kg to 15kg film-forming agent is selected, the dosage is 2ml to 10ml and the weight concentration ranges from 0.5 percent to 1.2 percent. The gum of the invention has reasonable mixture ratio of raw materials and obtained products can meet the product quality required by National Formulary.

Description

technical field [0001] The invention relates to seaweed chemistry and hollow capsules, in particular to a special glue for producing seaweed polysaccharide plant capsules. Background technique [0002] Empty capsules are divided into stomach-soluble empty capsules, enteric-coated empty capsules, soft capsules and hard-shell capsules. Medicinal empty capsule is a special pharmaceutical excipient, it enters the digestive system of the human body together with the pharmaceutical preparation and is absorbed by the human body, so the quality of medicinal empty capsule is directly related to the quality and safety of the finished drug. [0003] The used raw material overwhelming majority of hard-shell hollow capsule (commonly known as animal capsule) preparation at home and abroad is the animal protein colloid gelatin that the skin of pig or ox, bone are made. The hard-shell hollow capsule of animal origin has defects such as high water content, high cholesterol level and the pos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/38A61K9/48
Inventor 韩丽君史大永袁毅李敬房国明
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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