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Flavin adenine dinucleotide disodium salt freeze-dried powder needle preparation and preparation thereof

A technology of disodium dinucleotide and flavin adenine, which is applied in freeze-dried delivery, powder delivery, drug combination, etc., and can solve the problems of good solubility and limited clinical application

Inactive Publication Date: 2008-11-12
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Its function and properties are similar to flavin adenine dinucleotide, but its solubility is good, which is expected to improve the utilization rate of this kind of vitamin medicine. At present, the synthesis and analysis methods of flavin adenine dinucleotide disodium are very mature, but Its clinical application is not extensive, and research on pharmaceutical preparations with flavin adenine dinucleotide disodium as the active ingredient is still in progress

Method used

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  • Flavin adenine dinucleotide disodium salt freeze-dried powder needle preparation and preparation thereof
  • Flavin adenine dinucleotide disodium salt freeze-dried powder needle preparation and preparation thereof
  • Flavin adenine dinucleotide disodium salt freeze-dried powder needle preparation and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 FAD freeze-dried powder injection

[0016] prescription:

[0017]

[0018]

[0019] Preparation:

[0020] Weigh the prescribed amount of FAD and dissolve it in 80% water for injection to make FAD solution, add the prescribed amount of mannitol, adjust the pH value to 9.0-10.5, heat the medicinal liquid to about 60°C, add 0.1% activated carbon for injection according to the preparation amount , stir for 30min, filter and decarbonize and then use 0.22μm microporous filter membrane for fine filtration. After the intermediate is qualified, it is aseptically filled into a 2.7ml vial (the theoretical amount of each bottle is 1ml), and the liquid is placed in a freezer. Dry box, freeze for 4 hours to make the temperature drop to about -45°C; for the first sublimation for 12 hours, the temperature rises to about -5°C; for the second sublimation for 4 hours, the temperature rises to 30°C, take out after vacuum sealing, Cover and get it.

Embodiment 2

[0021] Example 2 FAD freeze-dried powder for injection

[0022] prescription:

[0023]

[0024] Preparation:

[0025] Weigh the prescribed amount of FAD and add it to heat to about 60°C to dissolve in 80% water for injection, then add the prescribed amount of dextran, adjust the pH value to 9.0-10.5, add 0.1% of activated carbon for injection according to the preparation amount, keep stirring for 30 minutes, filter, remove charcoal, and then use 0.22μm microporous filter membrane for fine filtration. After the intermediate is qualified, it is aseptically filled into a 2.7ml vial (the theoretical amount of each bottle is 1ml), and the medicinal liquid is placed in a freeze-drying box and frozen for 3 hours. , make the temperature drop to about -45°C; for the first sublimation for 8 hours, the temperature rises to about -5°C; for the second sublimation for 4 hours, the temperature rises to 30°C, take it out after vacuum pressing, and tie the cover.

Embodiment 3

[0026] Example 3: FAD freeze-dried powder injection

[0027] prescription:

[0028]

[0029] Preparation:

[0030] Take the FAD of the recipe quantity and add it to be heated to about 60 ℃ and dissolve in 80% water for injection, then add the glycine, sodium metabisulfite, sodium calcium EDTA of the recipe quantity, and adjust the pH value 9.0-10.5 after stirring and dissolving. Add 0.1% activated carbon for needles, keep stirring for 30min, filter, decarbonize, and then use 0.22μm microporous membrane for fine filtration. After passing the test of the intermediate, aseptically fill it into a 2.7ml vial (theoretical amount of each bottle is 1ml). ), put the medicinal liquid in a freeze-drying box, freeze for 3 hours, and make the temperature drop to about -45 °C; the first sublimation 14-16 hours, the temperature rises to about -5 °C; the second sublimation 4-6 hours, The temperature rises to 30 ℃, after vacuuming the lid, take it out, tie the lid, and that’s it.

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Abstract

The invention relates to a FAD-Na2 freeze-dried acanthopanax powder spasmolytic preparation and a method for preparing the same. The FAD-Na2 freeze-dried acanthopanax powder spasmolytic preparation is a drug composition made by mixing FAD-Na2 serving as medicinal active ingredients and pharmaceutically acceptable excipients. The preparation method is as follows: the FAD-Na2 is used as raw material and added with certain spices of excipients according to certain proportions; the mixture is prepared and developed by a technical means provided by the invention into freeze-dried acanthopanax powder spasmolytic agent which can be used for subcutaneous injection, intramuscular and intravenous injection and used to cure a variety of diseases caused by lacks of vitamin B2.

Description

technical field [0001] The invention relates to a freeze-dried powder injection preparation of disodium flavin adenine dinucleotide and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Flavin adenine dinucleotide (FAD) is the active substance in vivo phosphorylation of vitamin B2, and is an active riboflavin present in the body. As a prosthetic group of certain oxidoreductases, it is widely involved in various The redox reaction plays a role in the transmission of hydrogen in the biological oxidation system, and can also participate in the metabolism of carbohydrates, proteins, and fats, maintain normal visual function, and promote growth. In addition, FAD can also activate vitamin B6 and maintain the integrity of red blood cells. When the body is deficient, the biological oxidation process in the body will be affected, and normal metabolism will be disrupted, and typical symptoms of vitamin B2 deficiency will appear. ...

Claims

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Application Information

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IPC IPC(8): A61K31/7084A61K9/19A61P43/00
Inventor (发明人请求不公开姓名)
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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