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Oral care compositions comprising zinc and phytate

A technology of oral care and composition, which is applied in the field of oral care composition, and can solve the problems of short-term anti-plaque effect

Inactive Publication Date: 2008-12-24
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, water-soluble zinc compounds have the disadvantages of leaving an unpleasant astringent and metallic taste in the mouth and being too short-lived in action against plaque, calculus and as odor suppressants

Method used

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  • Oral care compositions comprising zinc and phytate
  • Oral care compositions comprising zinc and phytate
  • Oral care compositions comprising zinc and phytate

Examples

Experimental program
Comparison scheme
Effect test

example

[0107] The following examples further describe and illustrate examples within the scope of the present invention. These examples are given by way of illustration only and should not be construed as limiting the invention, since many changes are possible therein without departing from the spirit and scope of the invention.

[0108] Dentifrice Composition Example I

[0109] Dentifrice compositions according to the present invention (IA to IF) and comparative examples (IG and IH) are listed below in weight percent of components. These compositions are prepared using conventional methods.

[0110] Element

[0111] 1 Zinc Carbonate AC was supplied by Bruggemann Chemical: Newtown Square, PA, USA

Embodiment II

[0113] The antimicrobial efficacy of the present compositions was measured using an in vitro plaque glycolysis and regeneration model (i-PGRM). Efficacy in controlling supragingival calculus was defined as prevention of plaque calcification activity, using a modified plaque growth mineralization assay. The efficacy of formulations containing ingredients associated with tooth discoloration, such as tin and copper ions, to prevent tooth discoloration was measured using an in vitro thin film tea stain model (i-PTSM). The aesthetic acceptability of the formulation, such as reduction of astringency, taste acceptability and application experience, is determined by controlled consumer testing.

[0114] antimicrobial activity

[0115] The concentration and bioavailability of zinc ions required for therapeutic action regulation may vary for different clinical actions, eg, antiplaque versus gingivitis. However, since the therapeutic activity of zinc can be adjusted below this concen...

example III

[0123] Example III Anti-corrosion Efficacy

[0124] In addition to the therapeutic and cosmetic benefits mentioned above, it was demonstrated in studies using an in vitro erosion cycle model that the present composition comprising a water insoluble zinc salt and phytic acid also resists the onset and progression of dental erosion. Erosion in this context means the permanent loss of tooth material from the surface by the action of chemicals, such as harsh abrasives and acids, as distinguished from surface demineralization or caries, which is caused by the action of bacteria. Tooth erosion is a condition that does not involve plaque bacteria and is therefore distinct from dental caries, which is a disease caused by acids produced by plaque bacteria. It is believed that the present compositions deposit a barrier film or coating on the surface of the teeth thereby protecting the teeth from the erosive effects of exposure to aggressive agents.

[0125]Human tooth enamel samples ...

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Abstract

Disclosed are oral care compositions and their use, comprising in an orally acceptable carrier: (a) from about 0.01 to about 10 percent by weight of an essentially water-insoluble zinc compound, and (b) from about 0.01 percent to about 10 percent by weight of a compound having C-O-P bonds selected from polyphosphorylated inositol compounds such as phytic acid, myo-inositol pentakis(dihydrogen phosphate); myo-inositol tetrakis(dihydrogen phosphate), myo-inositol trikis(dihydrogen phosphate), and an alkali metal, alkaline earth metal or ammonium salt thereof. The compositions are effective in preventing and controlling oral cavity conditions including plaque, calculus, caries, periodontal disease, mouth malodor and dental erosion and have acceptable aesthetics without the unpleasant astringent and metallic taste associated with the use of zinc.

Description

field of invention [0001] The present invention relates to oral care compositions comprising a substantially water insoluble zinc compound and a phytate compound. Background of the invention [0002] The use of zinc compounds in oral care products such as mouthwashes, rinses and toothpastes is widely accepted and practiced. Zinc is used for its ability to neutralize bad breath and provide antimicrobial, antiplaque and anticalculus activity. The activity of zinc compounds is generally attributed to zinc ions, specifically divalent zinc ions (Zn +2 ). It has thus been found that water soluble and highly ionized zinc compounds such as zinc chloride which readily provide active zinc ions, typically water based, are useful in oral compositions. However, water-soluble zinc compounds have the disadvantages of leaving an unpleasant astringent and metallic taste in the oral cavity, and of being too short-lived in efficacy against plaque, calculus and as an odor suppressant. Poorl...

Claims

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Application Information

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IPC IPC(8): A61K8/55A61K8/27A61Q11/00
CPCA61K8/27A61K8/55A61Q11/00A61K8/20
Inventor 威廉·迈克尔·格兰多夫王晓利
Owner THE PROCTER & GAMBLE COMPANY
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