Loperamide hydrochloride dimethicone compound rapidly disintegrating oral membrane

Abstract

The present invention provides a hydrochloride loperamide dimethicone composite oral instant soluble membrane, which is used for relieving diarrhea with gastroenteric turgor symptom. The hydrochloride loperamide dimethicone composite oral instant soluble membrane contains hydrochloride loperamide and dimethicone; wherein, the weight proportion of the hydrochloride loperamide and the dimethicone is 1: 60 to 65 and the optimal weight proportion is 1:62.5. The present invention also discloses a preparation method of the hydrochloride loperamide dimethicone composite oral instant soluble membrane: water-soluble components are dissolved in water except for water-soluble polymers; at least a bio-acceptable water-soluble polymer ia added into a water solution under the stirring state; a polymer gel is obtained after full stirring and dispersing; a plasticizer is added into the polymer gel and evenly stirred; finally hydrochloride loperamide, dimethicone and other components are added to obtain the hydrochloride loperamide dimethicone polymer gel; degasifying is carried out, and the gel is evenly painted on a plate, blowing is carried out for heating and drying at the temperature of 70 to80 DEG, and cutting is carried out, thus the instant soluble membrane is obtained.

Description

technical field [0001] The invention relates to a loperamide hydrochloride simethicone compound oral instant film, which relates to a compound oral instant film preparation containing loperamide hydrochloride and simethicone and a preparation method thereof, which is used for relieving diarrhea accompanied by gastrointestinal flatulence symptoms. Background technique [0002] Loperamide Hydrochloride is an antidiarrheal drug that acts on opioid receptors on the intestinal wall to prevent the release of acetylcholine and prostaglandins, thereby inhibiting intestinal peristalsis and prolonging the residence time of intestinal contents. It can increase the tension of the anal sphincter, so it can inhibit fecal incontinence and urgency, and is used for acute and chronic diarrhea caused by various etiologies. For patients undergoing ileostomy, it can reduce the volume and frequency of defecation, and increase the consistency and hardness of stool. [0003] Due to the small surf...

AI Technical Summary

Problems solved by technology

[0004] At present, there are many oral preparations of loperamide hydrochloride and simethicone on the market at home and abroad, but because the traditional oral preparations must first disintegrate in the stomach to release the drug, the onset is slow and it is inconvenient to take. Although it can take effect quickly, it needs a spoon or a glass when taking it, and it is even more inconvenient to take it while driving, and it is not conducive to quantitative administration, and it is also inconvenient to carry. The preparation process of orally disintegrating tablets and orally dissolving tablets is more complicated , requires special equipment, slow disintegration when prepared by wet granulation and tableting technology, and unsatisfactory appearance, fragility and easy moisture absorption when prepared by freeze-drying method, which greatly affects the oral administration of loperamide hydrochloride and simethicone Application of preparation

Moreover, for the symptoms of diarrhea accompanied by flatulence in the gastrointestinal tract, no matter loperamide hydrochloride or oral preparations of simethicone are used alone, they cannot relieve the symptoms of both diarrhea and flatulence in the patient’s intestines well at the same time. Existing known technology also does not improve the suggestion of above defective

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