Hydrogel dressing and preparation method thereof

A hydrogel and water-soluble polymer technology, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problem that the strength and swelling properties of hydrogel cannot be both, and achieve good ability of absorbing wound exudate, good pain relief, etc. The effect of release performance and good toughness

Inactive Publication Date: 2009-01-07
SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a hydrogel dressing with high strength, good transparency, good air permeability and strong ability to absorb wound exudate in order to solve the problem that the strength and swelling property of the existing hydrogel cannot be combined

Method used

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  • Hydrogel dressing and preparation method thereof
  • Hydrogel dressing and preparation method thereof

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Effect test

Embodiment 1

[0022] Prepare an aqueous solution containing 15wt% polyvinyl alcohol, pour the solution into a plastic petri dish to form a 1mm thick solution layer after defoaming, cycle freezing and thawing twice (freezing temperature -20°C, time 7h; melting temperature 25°C, time 7h); Then pour 10wt% polyvinyl alcohol and 2wt% carboxymethyl cellulose on the physical gel to form a 1mm thick solution layer. 60 The Co source was irradiated with 70kGy, and the irradiation was carried out in an oxygen-free environment, and the solution was turned back and forth during the irradiation process to make the irradiation dose uniform, and then the gel was vacuum-sealed.

Embodiment 2

[0024] Prepare a mixed aqueous solution containing 6wt% polyvinyl alcohol and 2wt% water-soluble chitosan, pour the solution into a plastic petri dish to form a 3mm thick solution layer after defoaming, cycle freezing and thawing once (freezing temperature -20°C, time 7h; Melting temperature 25 DEG C, time 7h); Then pour the mixed aqueous solution of 7wt% polyvinyl alcohol and 5wt% polyvinylpyrrolidone on this physical gel again, form 3mm thick solution layer, this Petri dish is put into airtight container, After purging nitrogen and deoxygenating in 60 The Co source was irradiated with 70kGy, and the irradiation was carried out in an oxygen-free environment, and the solution was turned back and forth during the irradiation process to make the irradiation dose uniform, and then the gel was vacuum-sealed.

Embodiment 3

[0026] Preparation contains the mixed aqueous solution of 10wt% polyvinyl alcohol and 5wt% carboxymethyl chitosan, pours into the plastic petri dish after this solution defoams and forms the thick solution layer of 0.2mm, 7 times of circulation freezing and thawing (freezing temperature-20 ℃, Time 0.5h; Melting temperature 25 ℃, time 0.5h); Then pour into containing 9wt% polyethylene oxide and 3wt% agar on this physical gel again, form the thick solution layer of 0.4mm, irradiate under high-energy electron beam According to 40kGy, take it out, soak it in 2 times the volume of 5wt% aspirin solution for 48 hours under sterile conditions, take out the wiping surface solution and vacuum seal the gel.

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Abstract

The invention discloses hydrogel dressing which is composed of an upper layer and a lower layer. The lower-layer hydrogel is prepared by utilizing freeze thawing radiation method, and the upper-layer hydrogel is prepared by utilizing the radiation method; both the layers of hydrogel contain water-soluble polymer, and solvent for the residual; wherein, the lower-layer hydrogel contains polyvinyl alcohol. The invention also discloses a hydrogel-dressing preparation method which comprises the following steps: after the deaeration treatment of the water-soluble polymer solution containing polyvinyl alcohol, the hydrogel is prepared by utilizing circulating frozen thawing method; the water-soluble polymer solution after the deaeration treatment is positioned on the hydrogel, and then irradiation is performed under the high-energy rays. The hydrogel dressing has not only excellent strength and toughness, but also high transparence and wound fluid absorption ability. Meanwhile, the hydrogel dressing requires no additional chemical cross-linking agent or initiating agent, medical adhesive, and no reinforcing layer, such as fiber fabrics and woven fabrics, the two layers can be bonded firmly, and the preparation and the disinfection can be finished synchronously.

Description

technical field [0001] The invention relates to a hydrogel dressing and a preparation method thereof. Background technique [0002] Since Dr. George Winter, a British scientist, discovered in 1962 that a moist environment is beneficial to wound healing, various new dressings have been widely developed, and hydrogel dressings are one of the most important ones. A large number of studies have shown that hydrogel dressings have the advantages of being breathable, moisturizing, soft and can significantly relieve pain, and will not damage the healed wound tissue when changing the dressing, and have unique advantages in promoting wound healing. [0003] Chemical crosslinking, cyclic freezing and thawing, and radiation are currently commonly used methods for preparing hydrogels. Polyacrylic acid hydrogels prepared by chemical crosslinking were commercialized by Geistlich & Sons Co. in 1983. However, hydrogels prepared by chemical cross-linking usually have residual unreacted mono...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22A61L15/44
Inventor 杨小敏朱智勇李文新
Owner SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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