Preparation method of hydroxyapatite microsphere
A technology of hydroxyapatite and microspheres, which is applied in the field of preparation of hydroxyapatite microspheres, can solve the problems of high cost, complicated production process, unfavorableness and the like, achieves large specific surface and pores, good application prospects, easy to obtain Effect
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[0022] Example 1
[0023] In the first step, Ca(OH) at 0.6 mol / L 2 Add 100ml of the suspension to a three-necked flask placed on an electric heating mantle, and add 10ml of 0.3 mol / L ammonium salt of EDTA with stirring;
[0024] In the second step, add 20ml 0.36 mol / L (NH 4 ) 2 HPO 4 And 80ml 0.6 mol / L NH 4 HCO 3 After the solution is evenly mixed, it is gradually dripped into the three-necked flask, the dripping time is 120min, and the stirring speed is 800r / min;
[0025] In the third step, the three-necked flask was heated to 50°C, and 80ml of 0.36 mol / L H was added dropwise to it 3 PO 4 Solution, the dripping time is 150min, after the dripping is completed, continue to react for 300min to obtain the hydroxyapatite slurry;
[0026] In the fourth step, the slurry was naturally cooled overnight, filtered, washed twice with deionized water, and then dried in a vacuum drying oven at 50°C for 24 hours, and ground after cooling to obtain hydroxyapatite microspheres .
[0027] The XRD ...
Example Embodiment
[0028] Example 2
[0029] In the first step, at 0.4 mol / L Ca(OH) 2 Add 100ml of the suspension into a three-necked flask placed on an electric heating mantle, and add 5ml of EDTA ammonium salt at 0.3 mol / L under stirring;
[0030] In the second step, add 50ml of 0.24 mol / L (NH 4 ) 2 HPO 4 And 50ml 0.4mol / L NH 4 HCO 3 After the solution is evenly mixed, it is gradually dripped into the three-necked flask, the dripping time is 120min, and the stirring speed is 500r / min;
[0031] In the third step, the three-necked flask was heated to 80°C, and 50ml of 0.24 mol / L H was added dropwise to it 3 PO 4 Solution, the dripping time is 100min, after the dripping is completed, continue to react for 200min to obtain the hydroxyapatite slurry;
[0032] In the fourth step, the slurry was naturally cooled overnight, filtered, washed twice with deionized water, and then dried in a vacuum drying oven at 50°C for 24 hours, and ground after cooling to obtain hydroxyapatite microspheres .
[0033]After...
Example Embodiment
[0034] Example 3
[0035] In the first step, Ca(OH) at 0.6 mol / L 2 Add 100ml of the suspension to a three-necked flask placed on an electric heating mantle, and add 10ml of 0.3 mol / L ammonium salt of EDTA with stirring;
[0036] In the second step, 70ml 0.36 mol / L (NH 4 ) 2 HPO 4 And 30ml 0.6 mol / L NH 4 HCO 3 After the solution is evenly mixed, it is gradually dripped into the three-necked flask, the dripping time is 120min, and the stirring speed is 900r / min;
[0037] In the third step, the three-necked flask was heated to 80°C, and 30ml of 0.36 mol / L H was added dropwise to it 3 PO 4 Solution, the dripping time is 60min, after the dripping, continue to react for 300min to obtain the hydroxyapatite slurry;
[0038] In the fourth step, the slurry was naturally cooled overnight, washed twice with deionized water, then dried in a vacuum drying cabinet at 50°C for 24 hours, and ground after cooling to obtain hydroxyapatite microspheres.
[0039] The SEM image of the obtained hydroxya...
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