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Vaginal suppository for exterminating AIDS virus and sperm

A vaginal suppository and suppository technology, applied in the field of medicine, can solve the problems of lack of correction and repair function of reverse transcriptase, high mutation frequency, etc.

Active Publication Date: 2009-02-11
孙祖越
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Because HIV is a retrovirus, and reverse transcriptase lacks the correction and repair function, the mutation frequency of HIV is very high, and about 10 base errors will be introduced in each round of replication

Method used

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  • Vaginal suppository for exterminating AIDS virus and sperm
  • Vaginal suppository for exterminating AIDS virus and sperm
  • Vaginal suppository for exterminating AIDS virus and sperm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Xiaobiling vaginal suppository is used to kill the AIDS virus. Xiaobiling vaginal suppository, the weight percentage of each ingredient is: nonoxynol 1-3%, polyketene iodine 3-5%, others are made of polyethylene glycol, sodium bicarbonate and anhydrous citric acid Suppositories.

[0017] Materials and methods

[0018] 1. Determination of drugs and compounds

[0019] The sample to be tested, Xiaobiling vaginal suppository of the present invention, and the positive control compound sodium hypochlorite were purchased from Kunming Hengxin Libang Economic and Trade Co., Ltd.

[0020] 2. Reagents and solutions

[0021] 1. Reagent

[0022] HEPES(N-2(2-Hydroxyothyl)piperazine-N'-(2-ethanesufonicacid), MTT(3,(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide), DMF(N,N '-Dimethyl formamine, Penicillin, Streptomycin sulfate, and Glutamine were purchased from Sigma; 2-Mercaptoethanol (2-ME, 2-Mercaptoethanol) was from Bio-Rad Products. RPMI-1640 and newborn calf serum are produ...

Embodiment 2

[0052] Xiaobiling vaginal suppository of the present invention is used for killing sperm

[0053] 1. Test product

[0054] 1. Name: Xiaobiling vaginal suppository

[0055] 2. The test product number: P2006-10;

[0056] 3. Properties: suppository;

[0057] 4. Provider: Shanghai Mingyueguang Biological Technology Development Co., Ltd.

[0058] 5. Lot number: 20060808

[0059] 6. Content: A total of 12 groups, the content of nonoxynol ether (NP-9) and polyketene iodine (PVP-I) are:

[0060] Experimental group 1: NP-9 (100mg / grain) + PVP-I;

[0061] Experimental group 2: NP-9 (80mg / grain) + PVP-I;

[0062] Experimental group 3: NP-9 (64mg / grain) + PVP-I;

[0063] Experimental group 4: NP-9 (100mg / grain) + PVP-I;

[0064] Experimental group 5: NP-9 (80mg / grain) + PVP-I;

[0065] Experimental group 6: NP-9 (64mg / grain) + PVP-I;

[0066] Experiment 7 group: NP-9 (100mg / grain) + PVP-I;

[0067] Experimental group 8: NP-9 (80mg / grain) + PVP-I;

[0068] Experimental 9 groups: NP-9 (100mg / ca...

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Abstract

The invention discloses a vaginal suppository used for killing AIDS virus and sperms, relating to an external drug and belonging to the technical field of medicines. A vaginal suppository compound that is a compound preparation takes nonoxynol(NP-9) and PVP-I as two main drugs and a proper amount of carbowax, sodium bicarbonate and citric acid anhy as accessories, wherein, the suppository is prepared by all the components according to the following weight percentages; 1-3 percent of nonoxynol, 3-5 percent of PVP-I and the rest of carbowax, sodium bicarbonate and citric acid anhy and the like of the proper amount. The dosage form of the vaginal suppository compound is the suppository, which has remarkable effect in the use for killing AIDS virus and sperms.

Description

Technical field [0001] The invention relates to a medicine for external use, especially a vaginal suppository for killing HIV and sperm, belonging to the technical field of medicine. Background technique [0002] Reproductive tract infections, unsatisfactory condom acceptance rates, and unmarried pregnancies have seriously affected the reproductive health and social stability of the general public. Currently on the market, such as chlorine-containing disinfectants, ozone, peracetic acid and hydrogen peroxide and other strong disinfectant lotions and vaginal suppositories, as well as single-chain quaternary ammonium salts and herbal low-efficiency disinfectants, are used in human reproduction. The health aspect has played a positive role. As for birth control contraceptive products, the products formed on the market mainly focus on the following aspects: 1. Contraceptive methods that block pregnancy pathways: such as various male condoms, vaginal diaphragms, cervical caps and fema...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/085A61K31/787A61P15/02
Inventor 孙祖越
Owner 孙祖越
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