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Precipitation polymerization preparation method of crosslinked polystyrene microspheres

A cross-linked polystyrene and styrene technology, which is applied in the preparation of microspheres and microcapsule preparations, can solve the problems of high toxicity of acetonitrile and environmental pollution, and achieve the effects of reducing toxicity, simple and easy preparation method, and reducing dosage

Inactive Publication Date: 2009-02-11
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, acetonitrile is highly toxic, and excessive use will cause great pollution to the environment.

Method used

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  • Precipitation polymerization preparation method of crosslinked polystyrene microspheres
  • Precipitation polymerization preparation method of crosslinked polystyrene microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Mix 47.5 milliliters of acetonitrile, 2.5 milliliters of n-butanol, 0.35 milliliters of styrene, 0.15 milliliters of divinylbenzene and 0.0136 grams of azobisisobutyronitrile, and deoxygenate with nitrogen gas for 15 minutes, constant oscillation frequency 40 rpm, 65 Celsius reaction for 16 hours. The polymerized product was separated by centrifugation, washed with absolute ethanol, and dried to constant weight.

[0020] Gained polystyrene microsphere average particle diameter is 1.22 micron, and crosslinking degree is 24%, and monodispersity is good, and its scanning electron micrograph is as follows: figure 1 shown.

Embodiment 2

[0022] Mix 45 milliliters of acetonitrile, 5 milliliters of n-butanol, 0.25 milliliters of styrene, 0.25 milliliters of divinylbenzene and 0.0048 grams of azobisisobutyronitrile, and deoxygenate with nitrogen gas for 15 minutes, constant oscillation frequency of 70 rpm, 70 Celsius for 24 hours. The polymerized product was separated by centrifugation, washed with absolute ethanol, and dried to constant weight.

[0023] Gained polystyrene microsphere average particle diameter is 1.67 micron, and crosslinking degree is 40%, and monodispersity is good, and its scanning electron micrograph is as follows: figure 2 shown.

Embodiment 3

[0025] Mix 47.5 milliliters of acetonitrile, 2.5 milliliters of n-butanol, 1.05 milliliters of styrene, 0.45 milliliters of divinylbenzene and 0.0135 grams of azobisisobutyronitrile, and deoxygenate with nitrogen gas for 15 minutes, constant oscillation frequency of 100 rpm, 75 Celsius for 24 hours. The polymerized product was separated by centrifugation, washed with absolute ethanol, and dried to constant weight.

[0026] The obtained polystyrene microspheres have an average particle diameter of 2.20 microns, a crosslinking degree of 24%, and good monodispersity.

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Abstract

The invention discloses a preparation method of monodisperse micron-scale crosslinked polystyrene microspheres. The preparation method is characterized in that: monomer styrene, divinyl benzene and zaodiisobutyronitrile as an initiator are dissolved in a mixed solvent formed by acetonitrile and butanol; nitrogen gas is fed into the obtained mixture to remove oxygen for 15 minutes; reaction is carried out with oscillation under stable temperature; the polymerization product is centrifugally separated, washed by anhydrous alcohol and dried till the weight is stable. The crosslinked polystyrene microspheres with good monodisperse performance, crosslinked degree reaching 64 percent and grain sizes arranging from 1 micron to 4 microns can be obtained by the preparation method disclosed by the invention. The preparation method is applicable to the fields, such as biological medication, electronic information, chromatographic separation, cosmetic and coatings.

Description

technical field [0001] The invention relates to a method for preparing monodisperse micron-level polystyrene microspheres with high crosslinking degree, and belongs to the field of polymer microsphere materials. Background technique [0002] Monodisperse micron-scale cross-linked polystyrene microspheres have large specific surface area, strong adsorption, high mechanical strength, good surface reactivity, excellent hydrophobicity, non-biodegradability, good controllability of particle size, and are not affected by general solvents. Dissolution or swelling, easy application and recycling and many other advantages, so it is more and more widely used in the fields of standard metrology, biomedicine, analytical chemistry, information information, chemical industry and microelectronics. In recent years, the preparation of monodisperse cross-linked polymer microspheres has become a hot spot in the field of polymer science. [0003] The general methods for preparing polymer micro...

Claims

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Application Information

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IPC IPC(8): B01J13/14C08F2/06C08F12/08C08F20/26
Inventor 陈厚姜红燕梁英
Owner LUDONG UNIVERSITY
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