Double braid nerve trachea and preparation method thereof

A technology of nerve conduit and double-layer braiding, which is applied in the field of biomedical materials and tissue engineering, can solve the problems of brittle collapse, high brittleness, increased nerve conduit, bridge defect distance, nerve regeneration, etc., and achieve good cell compatibility , good mechanical properties, the effect of increasing the distance

Active Publication Date: 2009-02-18
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current problem of this material is its high brittleness, and it is easy to break and collapse when the tube wall is thin
[0008] On this basis, braided nerve conduits still have obvious deficiencies in increasing the distance that the nerve conduit can bridge defects and improving the quality and speed of nerve regeneration.

Method used

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  • Double braid nerve trachea and preparation method thereof
  • Double braid nerve trachea and preparation method thereof
  • Double braid nerve trachea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A double-layer braided nerve conduit is composed of an outer wall made of polyglycolide-lactide yarn and an inner wall made of chitin non-woven fabric.

[0024] The above-mentioned double-layer braided nerve guide is prepared by the following method: attaching chitin non-woven fabric to a mandrel to form an inner tube wall, and weaving polyglycolide-lactide yarns on its outer layer to form an outer tube wall; Set it at 90°C for 2 minutes, wash it with absolute ethanol, and set it at 90°C for 1 minute; remove the outer tube wall made of polyglycolide-lactide and the inner tube wall made of chitin non-woven fabric from the mandrel At the same time, it was withdrawn and freeze-dried at -50°C for 2 hours.

Embodiment 2

[0026] A double-layer braided nerve conduit is composed of an outer wall made of polyglycolide-lactide yarn and an inner wall made of chitin non-woven fabric.

[0027]The above-mentioned double-layer braided nerve guide is prepared by the following method: attaching chitin non-woven fabric to a mandrel to form an inner tube wall, and weaving polyglycolide-lactide yarns on its outer layer to form an outer tube wall; Set it at 105°C for 5 minutes, wash it with absolute ethanol, and set it at 100°C for 2 minutes; remove the outer wall made of polyglycolide-lactide and the inner wall made of chitin non-woven fabric from the mandrel At the same time, it was withdrawn and freeze-dried at -40°C for 3 hours.

Embodiment 3

[0029] A double-layer braided nerve conduit is composed of an outer wall made of polyglycolide-lactide yarn and an inner wall made of chitin non-woven fabric.

[0030] The above-mentioned double-layer braided nerve guide is prepared by the following method: attaching chitin non-woven fabric to a mandrel to form an inner tube wall, and weaving polyglycolide-lactide yarns on its outer layer to form an outer tube wall; Set it at 100°C for 3.5 minutes, wash it with absolute ethanol, and set it at 95°C for 1.5 minutes; the outer wall made of polyglycolide-lactide and the inner wall made of chitin non-woven fabric are removed from the core The sticks were withdrawn at the same time, and freeze-dried at -45°C for 2.5 hours.

[0031] The performance test of the double-layer braided nerve guide of embodiment 1-3 is as follows:

[0032] 1. Measurement and comparison of porosity: The concept equivalent to porosity is "relative density", which is the ratio of the apparent density of a po...

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PUM

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Abstract

The invention provides a double-layer knitting nerve duct having the characteristics that the double-layer knitting nerve duct consists of an outer layer tube wall knitted by polyglycollide-lactide yarns and an inner layer tube wall made from chitin non-woven fabrics, and also provides a method for preparing the double-layer knitting nerve duct having the characteristics that the method comprisesthe following steps of: attaching the chitin non-woven fabrics on a core bar and knitting the polyglycollide-lactide yarns on an outer layer; forming the polyglycollide-lactide yarns for 2 and 5 minutes at a temperature of between 90 and 105 DEG C, cleaning the polyglycollide-lactide yarns with anhydrous alcohol, and forming the polyglycollide-lactide yarns for 1 and 2 minutes at a temperature ofbetween 90 and 100 DEG C; taking down a polyglycollide-lactide knitting layer and a chitin non-woven fabric layer from the core bar at the same time, and freeze-dry the polyglycollide-lactide knitting layer for 2 and 3 hours at a temperature of between 50 below zero and 40 DEG C. The double-layer knitting nerve duct has the advantages of long-distance bridging defect, good quality and fast speed for nerve regeneration and good mechanical property, and contributes to regulation of a pH value in the body.

Description

technical field [0001] The invention relates to a double-layer braided nerve guide and a preparation method thereof, belonging to the technical field of biomedical materials and tissue engineering. Background technique [0002] Nerve conduits are prefabricated tubular structures made of biological or non-biological materials to guide the growth of damaged nerves. It bridges between nerve stumps and is used to repair nerve damage. At present, the biodegradable absorbing materials used for artificial nerve conduits at home and abroad are mainly polylactic acid (PLA), chitosan (chitosan), collagen (collagen), polyglycolic acid (PGA), polyphosphazenes (polyphosphazenes) and their copolymerization. The reason is that these materials have a wide range of sources and are cheap; they are biodegradable and have no toxic effect on nerve tissue. In addition, with the in-depth research on the cellular and molecular mechanisms of peripheral nerve regeneration, people gradually realized...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/12A61L29/06A61L29/04
Inventor 陈南梁孙丹丹张佩华王文祖沈尊理郯志清
Owner DONGHUA UNIV
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