Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Calcium orthophosphate porous particle material with biological activity as well as preparation method and use thereof

A porous particle and biologically active technology, applied in the field of biomedical materials and regenerative medicine, can solve the problems of limited bone damage speed coordination and matching, and achieve the effect of simple process, uniform size, and easy control of doping rate

Inactive Publication Date: 2009-03-04
ZHEJIANG UNIV
View PDF5 Cites 34 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent ZL200610049179.5 uses layer-layer assembly technology to prepare a shell-core multilayer microstructure nanoparticle material with silica gel nanospheres as the core carrier, calcium phosphate as the shell, and multiple trace elements. The method solved the problem of synergistic assembly of multiple active substances for the first time, and achieved the excellent effect of synergistically controlled release of multiple trace elements. However, the technical means to independently control the degradation rate of the silica gel nanosphere particle carrier in the preparation method is still limited, so the material exists. Coordination and matching of biodegradation process and bone damage speed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium orthophosphate porous particle material with biological activity as well as preparation method and use thereof
  • Calcium orthophosphate porous particle material with biological activity as well as preparation method and use thereof
  • Calcium orthophosphate porous particle material with biological activity as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 474 mL of deionized water into a three-neck flask with a capacity of 1000 mL, place it in a water bath at 60° C. with continuous mechanical stirring (650 rpm) and heat up, then add 40 μL of an aqueous solution of sodium polyaspartate with a concentration of 10 wt % and a concentration of 0.25 mol / 1.0 mL of sodium silicate solution in L, and 25 mL of sodium phosphate solution with a concentration of 0.5 mol / L was added. After the mixed solution reached 60°C and stabilized, the pH value of the above mixed solution was adjusted to 5.0 with dilute HCl and NaOH solution; then 0.5mol / L Ca(CH 3 COO) 2 ·H 2 O solution 30.25mL and SrCl 2 , Zn(NO 3 ) 2 and MgCl 2 Dilute 1.0 mL of the original solution with a concentration of 0.25 mol / L to prepare a 500 mL aqueous solution, and slowly add it dropwise to a three-necked flask; After 6, 6.5 and 16 hours, part of the solution was sucked out, and after filtration, the microsphere particles were washed with deionized water an...

Embodiment 2

[0045] Add 474 mL of deionized water to a three-necked flask with a capacity of 1000 mL, place it in a water bath at 37° C. with continuous mechanical stirring (450 rpm) and heat up, then add 40 μL of an aqueous solution of sodium polyaspartate with a concentration of 10 wt % and a concentration of 0.25 mol / 2.5mL of sodium silicate solution in L, and 50mL of sodium phosphate solution with a concentration of 0.5mol / L was added, and after the mixed solution reached 37°C and stabilized, the pH value of the above mixed solution was adjusted to 6.5 with dilute HCl and NaOH solution; then 0.5mol / L Ca(CH 3 COO) 2 ·H 2 O solution 49mL and SrCl 2 , Zn(NO 3 ) 2 and MgCl 2 Dilute 1.0 mL of each original solution with a concentration of 0.25 mol / L to prepare a 500 mL aqueous solution, and slowly add it dropwise into a three-necked flask; after adding the mixed solution containing the above trace elements, continue to stir and age for 3 hours, and then filter The microsphere particl...

Embodiment 3

[0048] With embodiment 1, difference is that stirring velocity is 550rpm, and concentration is that the sodium silicate solution add-on of 0.25mol / L is 0.5mL, and concentration is the Ca(CH of 0.50mol / L 3 COO) 2 ·H 2 O solution 23.75mL, after aging for 3 hours, the morphology of microsphere particles is as follows Figure 4 As shown in (a), the particle size is 80 to 150 μm. SiO in microsphere particles after aging for 3.5 and 6.5 hours 2 Contents are 0.25wt% and 0.29wt%, zinc, strontium and magnesium content such as Figure 6 shown.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
sizeaaaaaaaaaa
sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a porous granular material of bioactive calcium phosphate, which are porous microspherical granules mixed with two or more microelements of strontium, zinc, magnesium and silicon, and the grain diameter of the microspherical granules varies from 0.5 to 3000 mum. The preparation method comprises the following steps: under stirring conditions, inorganic salt containing SiO3<2->, PO4<3-> is added into aqueous solution of Poly aspartic acid sodium or polyacrylic acid sodium, and the PH value and the temperature of the aqueous solution are adjusted; aqueous solution drips of inorganic salt of two or more ions containing Ca<2+>, Sr<2+> and Mg<2+> are added to the aqueous solution for aging, filtration, washing, and drying. The material has the characteristics of simple preparation process, easy control of the size of the porous microspherical granules, and easy operation of the compound ratio of the multiple microelements. The microspherical granular material can be directly used for filling bone defect without secondary granulation or molding process, and have the advantage of fine biodegradation properties and the obvious improvement in repairing bone injury, thus being suitable for the regeneration medical application in the field of repairing bone injury.

Description

technical field [0001] The invention relates to a biologically active calcium phosphate porous particle material doped with trace elements and its preparation method and application, belonging to the field of biomedical materials and regenerative medicine for human bone and tooth tissue lesion and damage repair treatment. Background technique [0002] The rapid and complete regenerative repair of a series of bone injuries such as bone tissue necrosis caused by tumors and inflammation, bone loss and fractures caused by osteoporosis, and bone defects caused by mechanical forces is currently a difficult problem in clinical medicine. In the late 1960s, Professor Larry Hench first discovered a kind of CaO, SiO 2 ,P 2 o 5 and Na 2 The glass powder fired from the compound of the O component induces the deposition of bone-like apatite in the damaged bone tissue, can form a bone chemical bond with the living bone tissue, and develop into a bone repair material for clinical applica...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/56A61F2/28C01B25/32
Inventor 苟中入
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com