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Medical operation suture thread

A technology of surgical sutures and sutures, applied in the field of sutures, can solve the problems of large systemic side effects, affecting the recovery of patients, and inability to administer sufficient doses, and achieve the effect of reducing drug dosage and systemic side effects

Inactive Publication Date: 2009-03-11
李捷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the degree of pain after surgery is often severe, narcotic analgesics represented by opioids are widely used clinically, but most of them are short-acting preparations, which cannot be administered on demand due to addiction and other problems; and The systemic side effects of long-acting preparations are relatively large, which often affects the recovery of patients and cannot be administered in sufficient doses. Therefore, most patients still need to bear the pain to survive the acute period after surgery.

Method used

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  • Medical operation suture thread
  • Medical operation suture thread
  • Medical operation suture thread

Examples

Experimental program
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Effect test

Embodiment 1

[0014] The braided suture was prepared with chitosan, and bupivacaine was used as an analgesic drug. The suture was braided around, that is, the fiber containing bupivacaine was used as the central axis, and other ordinary fibers were woven around the central axis.

[0015] The process flow for preparing chitosan fibers containing bupivacaine is as follows: dissolving chitosan in 3% dilute acid solution, adding 0.6% urea and 0.3% zinc acetate as auxiliary agents to prepare 5% chitosan fibers The spinning dope, add bupivacaine dry powder in the spinning dope, the drug concentration is controlled at 20%. After filtering and vacuum degassing the spinning dope dissolved in bupivacaine, spray it into a 6% NaOH solution through a spinneret with a diameter of 0.10mm to solidify it, and then stretch it 1.5 times. It is obtained by drying at ℃ for 30 minutes.

[0016] The process flow for preparing ordinary chitosan fiber is as follows: dissolving chitosan in 3% dilute acid solution, ...

Embodiment 2

[0018] Embodiment two: use polylactide-glycolide as material to prepare single-strand fiber suture, select bupivacaine as an analgesic drug, and the preparation method of covering bupivacaine drug coating on polylactide-glycolide fiber is as follows: Polylactide glycolide and tetrahydrofuran were formulated into a 3% solution, and bupivacaine and deionized water were formulated into a 3% aqueous solution. The two solutions were prepared at a ratio of 1:10, and the drug-loaded polylactide was prepared by dip coating. Glycolide coating.

[0019] Next, a local acute pain model will be established to evaluate the effect of the present invention.

[0020] (1) Fray brush stimulation method after operation on common peroneal nerve and tibial nerve ring in rat hindlimb:

[0021] Principle: After the animal's common peroneal nerve and tibial nerve ring are connected, the side of the hind limb will produce pain sensitivity within 4-12 hours and last for 30-60 days. During this period o...

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PUM

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Abstract

The invention discloses a medical suture that contains an analgesic drug which can slowly release in a body. The suture is combined with the analgesic drug. The medicine administration is simultaneously accomplished during suture, and the medicine is slowly released from the suture, thereby achieving the long term acesodyne effect on the sutured part. Due to the partial medicine administration, the medicine dosage is greatly reduced compared with the whole body medicine administration, and the side effect on the whole body is remarkably reduced while the partial effective pain stop is achieved.

Description

technical field [0001] The present invention relates to a surgical suture. Background technique [0002] Surgery is an important method for treating many diseases such as trauma, tumor, infection and deformity, and some are even the only method. Hemostasis and suturing are the basic techniques of surgery. Practice has proved that the pain at the surgical suture site often persists after the operation (at least 1 week). The traditional method of surgical pain relief is to apply analgesics systemically or locally. Since the degree of pain after surgery is often severe, narcotic analgesics represented by opioids are widely used clinically, but most of them are short-acting preparations, which cannot be administered on demand due to addiction and other problems; and The systemic side effects of long-acting preparations are relatively large, which often affect the recovery of patients and cannot be administered in sufficient doses. Therefore, most patients still need to bear th...

Claims

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Application Information

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IPC IPC(8): A61L17/10
Inventor 李捷
Owner 李捷
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