Method for synthesizing ferulaic acid glyceride in surfactant modified organic solvent

A technology of ferulic acid glyceride and surfactant is applied in the field of preparation of ferulic acid glyceride, which can solve the problem that pure ferulic acid glycerol monooleate cannot be obtained, increase the price of ferulic acid monooleic acid glyceride, Downstream technology is complicated and other problems, to achieve the effect of convenient source of raw materials, few steps, and easy purification process

Inactive Publication Date: 2009-03-25
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Yet still can not obtain the ferulic acid monoolein glyceride with high purity in these two kinds of media, and the reaction time is too long (more than 144 hours)
In addition, due to the existence of various by-products in the product that need to be

Method used

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  • Method for synthesizing ferulaic acid glyceride in surfactant modified organic solvent
  • Method for synthesizing ferulaic acid glyceride in surfactant modified organic solvent
  • Method for synthesizing ferulaic acid glyceride in surfactant modified organic solvent

Examples

Experimental program
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Effect test

Embodiment 1

[0020] (1) Dissolve 30g of AOT in 170g of methanol solution, add a certain amount of activated carbon (15g of activated carbon per 100g of AOT), mix and shake for 24 hours, filter and distill under reduced pressure until a small amount of filaments appear, and rectify under reduced pressure to remove methanol , to obtain purified AOT;

[0021] (2) Add 1.11 g of the purified AOT into 50 mL of toluene, shake and react at room temperature for 48 h, and then filter under normal pressure. Take 5mL of the modified toluene solution and add 2mL of isopropanone, if it turns blue, it means AOT modification of toluene is completed;

[0022] (3) Enzyme-catalyzed reaction In a 25 mL Erlenmeyer flask with a stopper, 1 mmoL of ethyl ferulate, 3 mmoL of triolein, 120 mg of Candida rugosa lipase, and 3 mL of AOT-modified toluene were added. The reaction bottle was reacted at 50° C. and 180 rpm in an air bath shaker for 12 hours, and the whole system was carried out under normal pressure durin...

Embodiment 2

[0024] (1) Dissolve 45g of AOT in 255g of methanol solution, add a certain amount of activated carbon (15g of activated carbon per 100g of AOT), mix and shake for 24 hours, filter and distill under reduced pressure until a small amount of filaments appear, and rectify under reduced pressure to remove methanol , to obtain purified AOT;

[0025] (2) Add 1.11 g of the purified AOT to 50 mL of toluene, shake and react at room temperature for 48 hours, and then filter under normal pressure. Take 5mL of the modified toluene solution and add 2mL of isopropanone, if it turns blue, it means AOT modification of toluene is completed;

[0026] (3) Enzyme-catalyzed catalytic reaction In a 25 mL Erlenmeyer flask with a stopper, 2 mmoL of ethyl ferulate, 6 mmoL of triolein, 240 mg of Candida rugosa lipase, and 3 mL of AOT-modified toluene were added. The reaction bottle was reacted at 48° C. and 180 rpm in an air bath shaker for 12 hours, and the whole system was carried out under normal pr...

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Abstract

The invention relates to a method for synthesizing ferulic acid glyceride in an organic solvent modified by a surface active agent, which comprises the steps: (1) methanol and activated carbon are used for purifying the surface active agent (AOT); (2) the purified AOT is used for modifying toluene which is a reaction medium; and (3) ferulic acid ethyl ester and triglycerides are catalyzed by the lipase of Candida rugosa in the toluene modified by the AOT, thus obtaining the ferulic acid glycerol. The method has mild and safe reaction condition and has the advantages of short reaction time, high yield rate, and the like; in addition, as the purity of the target product, namely the ferulic acid glyceride, does not require isolation and purification with down stream processing of bioengineering, thereby greatly lowering price and being more suitable for industrialized production.

Description

technical field [0001] The invention belongs to the field of preparation of glyceryl ferulate, in particular to a method for synthesizing glyceryl ferulate in an organic solvent modified by a surfactant. Background technique [0002] Glyceryl monooleate is currently the most widely used emulsifier in the world, and it is also an emulsifier widely used in the fields of food, medicine and cosmetics in my country. In recent years, with the increasing demand for functional emulsifiers in the market, ferulic acid monoolein has attracted people's attention. This is because this functional emulsifier not only maintains the good emulsifying properties of glyceryl monooleate, but more importantly, because ferulic acid is introduced into the glyceride molecule, it endows glyceryl monooleate with many new physiological activities. , such as anti-inflammation, pain relief, anti-thrombosis, anti-ultraviolet radiation, inhibition of free radical production, regulation of endocrine, and r...

Claims

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Application Information

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IPC IPC(8): C12P7/62
Inventor 朱利民郑妍权静
Owner DONGHUA UNIV
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