Unlock instant, AI-driven research and patent intelligence for your innovation.

Strong acid type ph fluorescent probe based on fluoro-boron fluorescent dye

A technology of fluoroboron fluorescent dyes and fluorescent probes, which is applied in the field of strong acid fluorescent molecular probes, can solve the problems of unsatisfactory fluorescent probe effects, and achieve the effects of good chemical/photostability, high yield, and high sensitivity

Inactive Publication Date: 2009-05-06
SHANXI DATONG UNIV
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the existing fluorescent probes for detecting pH values ​​are not ideal in a strong acid environment, the present invention provides a strong acid pH fluorescent probe based on fluoroboron dye

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Strong acid type ph fluorescent probe based on fluoro-boron fluorescent dye
  • Strong acid type ph fluorescent probe based on fluoro-boron fluorescent dye
  • Strong acid type ph fluorescent probe based on fluoro-boron fluorescent dye

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, a strong acid pH fluorescent probe based on fluoroboron dye, has the following general structural formula:

[0038]

[0039] in:

[0040] R 1 , R 2 is Cl or phenyl substituted with mercapto.

[0041] Such as Figure 6 As shown, the specific synthetic route is as follows:

[0042] (1) Synthesis of Intermediate 2: Add 36.5g (0.50mol) DMF into a 250mL three-necked flask, install a mechanical stirrer, cool to 0-5°C in an ice bath, and then slowly add 38.3g (0.25mol) dropwise Phosphorus oxychloride, add about 0.5h. Dissolve 15.1g (0.08mol) of N-bis(2-hydroxyethyl)aniline in 38mL of DMF, then add to the flask, stir and cool. Then heated to 85-90°C, stirred for 2.5h, and poured the solution into 500mL of ice water. Potassium carbonate was then slowly added and stirred vigorously until the solution was basic and a pale yellow solid precipitated. The precipitated solid was collected and recrystallized twice from ethanol to obtain 15.3 g (78.1%) of the whi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a strong acid type fluorescence molecule probe for pH (pondus Hydrogenii) examination in the field of fine chemistry industry, in particular to a strong acid type pH fluorescence probe based on fluorescent fluor borate dye, which solves the problem that the prior fluorescence probe for the pH examination has non-ideal effect in strong acid environment. The strong acid type pH fluorescence probe based on fluorescent fluor borate dye has a right-structure fomular. Probe molecules of the invention have an important application value. Particularly, the type of probe molecules has very high sensitivity and extremely good selectivity to the pH examination, and excitation wavelength is in a virtual region so that the type of probe molecules has wide application prospects as a reagent for the pH examination.

Description

technical field [0001] The invention relates to a strong-acid fluorescent molecular probe for pH detection in the field of fine chemical industry, in particular to a strong-acid pH fluorescent probe based on fluoroboron dye. Background technique [0002] The precise measurement of pH (proton concentration) is very important to chemical and biological research. The measurement of pH value generally uses glass electrodes, but it is not suitable for pH monitoring in vivo due to defects such as electrochemical interference and possible mechanical damage. It is well known that the change of fluorescence or light absorption properties of some organic compounds with pH can be used to indicate the change of acidity and alkalinity in the target medium. This pH measurement method based on optical signal changes can make up for the above-mentioned shortcomings of the glass electrode, and thus has been greatly developed. Because pH fluorescent molecular probes have higher sensitivity,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N21/64G01N21/80C09K11/02
Inventor 田茂忠王君玲袁跃华冯锋孟双明白云峰
Owner SHANXI DATONG UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com