Method for preparing stable water dispersion xanthophyll microcapsule from xanthophyll crystal

A technology of body lutein and lutein, applied in the field of lutein microcapsules, can solve problems such as poor safety, high energy consumption, and poor product stability, and achieve the effects of avoiding direct contact, increasing the application range, and widening the application range

Inactive Publication Date: 2009-05-20
黑龙江省嘉宝生物技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The foreign patent publication number US6863914 on this technology discloses a preparation method of a stable aqueous dispersion of lutein and a stable water-dispersible dry powder. The method first dissolves lutein in an organic solvent and water. In the mixed solution, due to the residual organic solvent, it is not conducive to the application in medicine and food industry, which is unfavorable to the stability of lutein, high energy consumption, and poor safety.
And my country's patent application number 200610049837.0 is called lutein microcapsules and its preparation method. No emulsifier is used in the preparation process, which affects the embedding effect and the solubility of the finished product, and the stability of the product is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 100g of lutein crystals (content is 80%), put in a 1000ml reactor, add 150g of vegetable oil, the reaction temperature is 80°C, react for 20min, add 60g of 1,2 propylene glycol, 40g of sucrose ester, 100g of deionized water, Stir and mix at 3000r / min for 1 hour, and homogenize the active compound by high-pressure homogenization to prepare a nano-scale lutein solution.

[0017] Weigh 100 g of sodium carboxymethyl cellulose and 200 g of ethyl cellulose, mix them, and use them as a capsule material to carry out fluidized granulation with the above-mentioned nano-scale lutein solution. The drying temperature is 65° C., and sieved to obtain a particle size of 10um lutein microcapsules 754g (content is 10.26%).

Embodiment 2

[0019] Weigh 50g of lutein crystals (80% content), put them in a 1000ml reactor, add 100g of vegetable oil, the reaction temperature is 80°C, react for 20min, add 20g of soybean lecithin, 20g of Tween 8020g, 40g of 1,2-propanediol, remove 60g of ionized water was stirred and mixed for 1 hour at a rotating speed of 3000r / min, and the active compound was homogenized by high-pressure homogenization to prepare a nano-scale lutein solution.

[0020] Weigh 200g of soluble starch and 50g of ethyl cellulose, mix them, and use them as a capsule material to perform fluidized granulation with the above-mentioned nano-scale lutein solution. Capsule 529g (content is 6.85%).

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Abstract

The invention relates to a method for preparing a stable aqueous dispersion lutein microcapsule from lutein crystals. The method comprises the following steps: dissolving the lutein crystals by an instant high-temperature fusion method, adding an emulsified substrate to the lutein for emulsification, and homogenizing an active compound through a high-pressure viscolizer to prepare nano-grade lutein solution; pelletizing and coating by a fluidized bed, adsorbing and condensing a capsule material to be molded through a droplet surface; and screening and packaging the material. Dispersed dry powder prepared by the lutein crystals by the microcapsule technology can be evenly dispersed in cold water or normal-temperature water so as to widen the application range of the microcapsule; meanwhile, the lutein is protected from directly contacting environment, and stability of the microcapsule is maintained in transportation, storage and use process; the lutein in the microcapsule dry powder has amorphous state, is favorable for human body to absorb and utilize, and can be widely applied in fields of foods and medicinal health food.

Description

(1) Technical field [0001] The invention relates to lutein microcapsule technology, in particular to a method for preparing stable water dispersion lutein microcapsules from lutein crystals. (2) Background technology [0002] Lutein is an oxygen-containing carotenoid widely found in bananas, kiwis, corns and marigolds. Morbidity and vision protection, especially in the prevention of senile cataract and age-related macular degeneration, etc., have received extensive attention. However, lutein is prone to oxidation under natural conditions, so its application is limited, and microencapsulation technology is an effective way to solve this problem. Microencapsulation is to embed solid, liquid, and gaseous substances (called core materials) into tiny capsules, and release them under certain conditions in a controlled manner. The embedded material is called the core material, and the embedded material is called the wall material. The advantage of microencapsulation is that it c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/047A61P39/06A61P35/00A61P9/00
Inventor 王宝根赵志刚王丹
Owner 黑龙江省嘉宝生物技术开发有限公司
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