Chinese medicine granule containing Huangyangning and preparation method thereof

A technology of traditional Chinese medicine granules and Huang Yang Ning is applied in the field of traditional Chinese medicine granules containing Huang Yang Ning and its preparation. Small, regular particle size distribution effect

Inactive Publication Date: 2012-09-05
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Take an appropriate amount of Huang Yang Ning;

[0046] The preparation of master batch: get the weight ratio of dextrin and starch to be 1: 1 mixture and pass through 200 mesh sieves, wherein 65% are put into the side spraying pot of fluidized bed as bottom material, and starch is added with water to prepare starch slurry (15%) Spray it in as slurry, and screen out small particles (particle size of 180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time remove the remaining 35% of dextrin from the dusting gun Sprinkle with the fine powder of starch to make the particle size of the mother nucleus grow, and screen out the master batch with a particle size of 450μ-600μ for use.

[0047] Preparation of product: take 450g of masterbatch, 50g of microcrystalline cellulose (200 mesh), 6000 polyethylene glycol (heated and melted) 500 g, Huang Yang Ning 320g; add microcrystalline cellulose and micro-powde...

Embodiment 2

[0049] Take an appropriate amount of Huang Yang Ning;

[0050] The preparation of master batch: get the mixture of micropowder silica gel and chitosan weight ratio of 1: 1 and pass through a 200 mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and PVP K30 is added with water, extract, and prepared. Adhesion-forming agent - sprayed in as slurry, and screened out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continued to spray starch slurry, and at the same time removed the remaining 35% from the dusting gun The micro-powder silica gel and the fine powder of chitosan are sprinkled in, so that the particle size of the mother nucleus grows, and the master batch with a particle size of 200μ-300μ is selected for use.

[0051] Product preparation: take 300g of masterbatch, 250g of microcrystalline cellulose (200 mesh), 14g of micropowder silica gel, and 200g of buxu...

Embodiment 3

[0053] Take an appropriate amount of Huang Yang Ning;

[0054] The preparation of master batch: get the mixture of dextrin and starch weight ratio of 1: 1 to cross 200 mesh sieves, wherein 65% is put into the side spraying pot of fluidized bed as bottom material, and starch, extract (after being folded to dry, account for mother batch) 15% of the weight of the grains), add water to prepare a slurry and spray it, and sieve out small particles (with a particle size of 180 to 250 μ) as the parent core, then put the parent core into the pot, continue to spray the starch slurry, and at the same time from the dusting gun. Sprinkle the remaining 35% fine powder of dextrin and starch to make the particle size of the parent nucleus grow, and screen out the master batch with a particle size of 300 μ to 400 μ for use.

[0055] Preparation of product: take 450g of masterbatch, 50g of microcrystalline cellulose (200 mesh), 6000 polyethylene glycol (heated and melted) 500 g, 1000g of Huang...

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Abstract

The invention provides a traditional Chinese medicine granular preparation containing buxenine and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by buxenine and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g / ml. The spheroidized particles of the invention have low single dose, are convenient in use, can be served as intermediate products of capsules, and also can be used for developing a traditional Chinese medicine controlled release preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing Huang Yangning and a preparation method thereof. Background technique [0002] Cyclovir Buxus D(C 26 H 46 N 2 O) It is a Chinese herbal medicine variety contained in the Chinese Pharmacopoeia (2000 edition), which activates qi and activates blood, and relieves pain by dredging collaterals. Cyclovitamin D is the active ingredient extracted from the woody parts of Chinese boxwood. Chinese small-leaf boxwood, also known as melon seed boxwood, is known as millennium dwarf, white day red, and evergreen. It is mainly produced in the south of the Yangtze River. Li Shizhen's "Compendium of Materia Medica" of the Ming Dynasty records that it has the functions of activating qi, activating blood, dispelling dampness and dredging collaterals; "Xiyang Zazu", "Classification of Herbal Properties"...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/88A61K31/56A61P9/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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