Adonis amurensis total-flavone mouth plaster

Abstract

The invention relates to a herba adonidis total flavonoids oral paster and preparation method thereof. The oral paster includes two layers, one is a medicine containing adhering layer, the other is a hydrophobic protecting layer; the medicine containing adhering layer contains 100-50mg of herba adonidis total flavonoids extract directly touched with the oral mucosa surface, while the hydrophobic protecting layer faces the oral cavity. The medicine is make to be released only to the ulcerative surface direction, and positioned on the focus region; consequently, the effect time is prolonged, the problem of saliva dilution to the medicine and low bioavailability are solved; while, the effective constituents are absorbed by the mucosa, liver first pass effect of the medicine is avoided, and the bioavailability is increased; additionally, the paster is applied directly on the ulcerative surface, can protect the ulcerative surface and promotes ulceration to cure. The herba adonidis total flavonoids oral paster in the invention can be used for treating ulcerations of the oral cavity in clinic.

Description

Technical field: [0001] The invention relates to a preparation of total flavonoids of calendula officinalis, in particular to an oral patch of total flavonoids of calendula officinalis, which is used for treating oral ulcers. [0002] The invention also relates to a preparation method of the total flavonoids of calendula officinalis oral patch. Background technique: [0003] Lateral calendula is the dried flower of Malvaceae hollyhock, which is widely used among the people. In ancient my country, there is a record of using side calendula to treat oral ulcers, "Zhizhi Fang": "Children with aphthous sores, burn the powder and apply it." Modern pharmacological research results show that the ethanol extract of Calendula officinalis (containing total flavonoids) has obvious anti-inflammatory, antibacterial, analgesic and other pharmacological effects, and the pharmacological effects have confirmed the feasibility of using it in the treatment of aphthous ulcers. Through the scre...

AI Technical Summary

Problems solved by technology

[0009] One object of the present invention is to provide a kind of oral patch of total flavonoids of calendula officinalis, which is used for the treatment of oral ulcer, and has the advantages of accurate and controllable drug content, good stability, no stimulation to mucous membrane, and protective effect on ulcer surface. Advantages; at the same time, the patch is a double-layer tablet prepared by secondary compression or spray film technology, and the drug can be released to the ulcer surface in one direction, so that the drug can be localized in the lesion, prolong the action time, and overcome the dilution of the drug by saliva , the problem of low bioavailability; at the same time, the active ingredients are absorbed by the mucosa, avoiding the liver first-pass effect of the drug, and improving bioavailability; in addition, the patch directly adheres to the surface of the ulcer, which can also directly protect the ulcer surface and effectively promote ulcer healing; And the patch is easy to administer, and the administration can be terminated by removing the preparation, which is convenient for patients to use

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