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Nanoemulsion compound transdermal spray for treating chronic gastritis and gastric ulcer

A chronic gastritis and nanoemulsion technology, applied in the field of medicine, can solve the problems of poor physical stability of volatile oil, poor transdermal absorption effect, and difficulty in exerting drug efficacy, so as to improve bioavailability efficiency, reduce drug dosage, and prevent liver disease. The first pass effect

Inactive Publication Date: 2012-04-11
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor physical stability of volatile oil, it is easy to fail
If it is made into a cream and applied to the skin, the transdermal absorption effect is not good, it is difficult to exert its medicinal effect, and it is easy to contaminate clothes

Method used

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  • Nanoemulsion compound transdermal spray for treating chronic gastritis and gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Preparation:

[0079] 1) Weigh the surfactant, co-surfactant, Amomum seed oil, patchouli oil, cinnamon oil, herb oil, tangerine peel oil, azone and deionized water according to the proportion of the formula for subsequent use;

[0080] 2) Fully stir and mix the surfactant and co-surfactant;

[0081] 3) Add spring amomum oil, patchouli oil, cinnamon oil, atractylodes oil, tangerine peel oil, azone in the formula ratio, and mix well;

[0082] 4) Slowly add deionized water dropwise at 20°C, and stir well until a clear, transparent, light yellow O / W nanoemulsion with low viscosity and fluidity is formed, and its weight is called 100 g.

[0083] The formula is as follows: 39.2 g of EL-40, 1.6 g of absolute ethanol, 5 g of spring amomum oil, 2.5 g of patchouli oil, 4.17 g of cinnamon oil, 3.33 g of herb oil, 2.5 g of tangerine peel oil, 0.5 g of azone, deionized 41.2 g of water, 100 g in total.

Embodiment 2

[0085] RH-40 35 g, absolute ethanol 1.6 g, PEG-600 0.4 g, spring Amomum seed oil 3 g, patchouli oil 2 g, cinnamon oil 3 g, atractylodes oil 2 g, tangerine peel oil 2 g, azone 1 g , 50 g of deionized water, a total of 100 g.

Embodiment 3

[0087] Tween-80 5 g, EL-40 40 g, 1,2-propanediol 0.5 g, spring Amomum oil 6 g, patchouli oil 1 g, cinnamon oil 2 g, atractylodes oil 4 g, tangerine peel oil 1 g, nitrogen Ketone 0.5 g, deionized water 40 g.

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Abstract

The invention discloses a nanoemulsion compound transdermal spray for treating chronic gastritis and gastric ulcer. The nanoemulsion compound transdermal spray is prepared from the following raw materials in percentage by mass: 35-45% of surfactant, 0.5-2% of auxiliary surfactant, 2-6% of fructus amomi oil, 1-4% of patchouli oil, 2-6% of cinnamon oil, 1-4% of atractylis oil, 1-3% of dried tangerine peel oil, 0.2-1% of azone and the balance of deionized water, wherein the sum of the mass percentages of the raw materials is 100%. The compound transdermal spray has rapid and durable pain alleviating action, has the effects of warming stomach and alleviating pain, warming spleen and promoting qi flow, eliminating inflammation and promoting tissue regeneration, improving microcirculation, promoting ulcer healing and the like, and is nontoxic and harmless to human bodies. The compound transdermal spray is applied to skin above navel and can be absorbed through massaging, has aromatic flavor, and does not pollute clothes, thereby greatly improving patient compliance.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a traditional Chinese medicine compound effective for treating chronic gastritis and gastric ulcer, in particular to a preparation method of compound nanoemulsion transdermal spray for treating chronic gastritis and gastric ulcer. Background technique [0002] The treatment of chronic gastritis and gastric ulcer currently has a variety of treatment options such as traditional Chinese medicine and western medicine, internal treatment and external treatment, and is faced with the following three inevitable problems: 1) Oral administration of traditional Chinese medicine is very irritating to the gastrointestinal tract. No appetite, often accompanied by nausea and vomiting, patients often reject this treatment; 2) Western medicines are taken orally to relieve pain, but they treat the symptoms but not the root cause, and cannot improve the state of the stomach from the root cause. Different de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/107A61K47/34A61K47/44A61P1/04
Inventor 欧阳五庆周莹欧阳伸雨
Owner NORTHWEST A & F UNIV
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