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Production of micro- and nanopore mass arrangements by self-organization of nanoparticles and sublimation technology

A nanopore and particle technology, which is applied in the field of preparing micropores and nanopore group arrays through nanoparticle self-organization and sublimation technology, can solve the problem of high cost, large area micropore and nanopore group arrays limited by optical lithography, long issues of time

Inactive Publication Date: 2009-06-10
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Current technical fabrication strategies for large-area arrays of microwells and nanowells are limited to optical lithography and imprint lithography.
These known methods are associated with a high technical complexity and therefore require very high costs and a long time

Method used

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  • Production of micro- and nanopore mass arrangements by self-organization of nanoparticles and sublimation technology
  • Production of micro- and nanopore mass arrangements by self-organization of nanoparticles and sublimation technology
  • Production of micro- and nanopore mass arrangements by self-organization of nanoparticles and sublimation technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Fabrication of well group arrays on glass substrates

[0040] A 10% by weight solution of bovine serum albumin (BSA) in water was provided on a clean small coverslip. After an exposure time of 10 minutes, an approximately 6 nm thick layer of BSA was adsorbed on the surface. The substrate was washed with Milli-Q-water in a glass beaker, then blown dry with nitrogen ( figure 1 a).

[0041] The functionalized small glass plate was dipped into a dispersion of polystyrene particles in water at a concentration of 2.5% by weight ( figure 1 b). Due to the electrostatic interaction between the BSA film and the sulfate groups on the surface of the particles, adsorption only occurred on the substrate area prepared with the adhesion promoter. The modified surface was washed with water to remove excess unattached particles, and the still wet sample was immersed in liquid nitrogen. The short-range ordering of particles in liquids due to mutual electrostatic repulsion is preserve...

Embodiment 2

[0045] Functionalizing substrates with organosilanes

[0046] Through 3-aminopropyltriethoxysilane (NH 2 (CH 2 )Si(OC 2 h 5 ) 3 ) to functionalize the substrate surface.

[0047] First, the glass substrate was treated with Caro's acid (H 2 o 2 / H 2 SO 4 (1:3 ratio) for 30 minutes, followed by Milli-Q-water and methanol in an ultrasonic bath. By dipping the substrate in 290ml methanol, 3ml aminosilane, 5ml H 2 Silanization of the surface was carried out in O and 18 μl of glacial acetic acid with a reaction time of 12 hours. Finally, the small glass slide was washed several times with methanol and dried (D. Cuvelier, O. Rossier, P. Bassereau, P. Nassoy, Eur. Biophys. J., 2003, 32, 342-354).

[0048] Incorporation of monolayers of different organosilane derivatives has been demonstrated on substrates such as silicon, alumina, quartz, glass, mica, zinc selenide, germanium oxide and gold (A. Ulman, Chem. Rev., 1996 , 96, 1533-1554).

[0049] The functionalized substrat...

Embodiment 3

[0051] Functionalization of silica particles with organosilanes

[0052] Inorganic silica particles were functionalized with triethoxysilyl-propyl-succinic anhydride (TESPSA). Silanization was achieved by incubating the particles in a 10% solution of TESPSA in toluene for 16 hours (G.K. Toworfe, R.J. Composto, I.M. Shapiro, PDucheyne, Biomaterials, 2006, 27(4), 631-642). The particles were separated from the reaction solution by centrifugation and sonication in several washing steps and washed with toluene and water. Finally, the carboxylated particles were resuspended in Milli-Q-water.

[0053] A 0.1% solution of polyethyleneimine (PEI) in water was coated on the cleaned glass surface. After an exposure time of 10 minutes, a thin PEI film was adsorbed on the surface. The substrate was washed and dried in a beaker of Milli-Q-water. Due to the amino groups on the substrate surface and the SiO 2 Attractive interactions between the carboxyl groups of the particles enable par...

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Abstract

The invention relates to a method for producing micro- and / or nanopore mass arrangements on a substrate, comprising the following steps: functionalizing the substrate surface in selected areas by applying a bonding agent; depositing, from an aqueous dispersion on the substrate surface, colloid particles which are capable of selectively binding to the functionalized areas of the substrate surface, an ordered monolayer of the particles forming on the substrate surface; removing non-bound colloid particles; freezing the substrate; and sublimating the residual water on the substrate in vacuo, the short-range order of the particle monolayer remaining intact.

Description

technical field [0001] The present invention relates to a new method for producing large-area arrays of micropore and nanopore clusters by pure self-organization. The array of holes can be controlled on the surface of the substrate in discrete areas. The size of the holes and the transverse hole spacing can be adjusted in the range of microns and nanometers. Background technique [0002] Micropores and nanopores or pore arrays, respectively, have numerous applications, eg as biomimetic model systems for simulating and explaining processes occurring at the level of the cell membrane. Nanopore systems are used to regulate intracellular and intercellular transport of ions and molecules and the maintenance of electrical potentials between cells and their environment. Thus, for example, the nucleus of a eukaryotic life form is separated from the rest of the cell by a nuclear membrane with permeable pores. The intertransmission of RNA, proteins and molecules between the nucleus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/02B01D71/02B01D67/00G03F1/14G03F1/20
CPCB01D67/0034B01D2323/36G03F1/20B01D69/02B01D67/0088B01D2325/16B01D71/022B01D67/0072B01D2323/28B01D2325/18B01D67/009
Inventor J·施帕茨T·勒米勒
Owner MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV
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