Method for producing phenoxypyridine derivative

A technology of piperidine and methyl, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve the problems such as preparation of intermediates that are not disclosed.
CN101454286AInactive Publication Date: 2009-06-10EISIA R&D MANAGEMENT CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EISIA R&D MANAGEMENT CO LTD
Publication Date
2009-06-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R 1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc, R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.
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Description

technical field

[0001] The present invention relates to an antitumor agent, a cancer metastasis inhibitor, etc., which have hepatocyte growth factor receptor (Hepatocyte growth factor receptor; hereinafter abbreviated as "HGFR") inhibitory action, antitumor action, angiogenesis inhibitory action, cancer metastasis inhibitory action, etc. A method for producing a phenoxypyridine derivative useful as an agent (hereinafter referred to as "the present compound") and a production intermediate of the production method. Background technique

[0002] It has been reported that HGFR is overexpressed in various tumors such as pancreatic cancer, gastric cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, kidney cancer, brain tumor, and ovarian cancer (Non-Patent Document 1). It is considered that HGFR expressed in the above tumor cells is constantly or stimulated by hepatocyte growth factor (hepatocyte growth factor; hereinafter referred to as "HGF"), which causes au...

Claims

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