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a cough tablet

A technology of Keke tablets and ephedra, which is applied in the field of traditional Chinese medicine preparations and its preparation, can solve problems such as poor hardness, rough surface, loosening, etc., and achieve the effects of ensuring operability, smooth and delicate surface, and improving stability

Active Publication Date: 2011-11-30
中山市恒生药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug has been widely used in the treatment of cough and shortness of breath due to its good curative effect and convenient administration. The proportion in each Keke Tablet is 61.1%, and the obtained plain tablet (the plain tablet is the tablet before the film coating) is very prone to poor hardness, easy to split, loose Problems such as unresolved, unable to be film-coated or surface rough after film-coating, so that the existing Keke tablets often have problems such as splits, poor stability, and unqualified testing within the validity period, which are difficult to be accepted by manufacturers and consumers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] The preparation method of Keke tablet of the present invention comprises the following steps:

[0033] (1), put a certain weight of sucrose powder in the high-efficiency mixing granulator, add a certain weight of 20-95% medicinal alcohol, and start the machine to mix evenly.

[0034] (2), add a certain weight of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator and mix with the mixture of sucrose and 20-95% medicinal alcohol, and simultaneously start the machine and the granulation cutter for granulation ( (i.e., granules are made into granules), so that all the materials form numerous small granules that use sucrose containing 20-95% medicinal alcohol as the crystal nucleus to extract dry cream powder from outsourcing medicinal materials.

[0035] (3), the above-mentioned granulated material is taken out, and passed through a 18-mesh steel screen by a swinging granulator.

[0036] (4), the above-mentioned materia...

Embodiment 1

[0038] Example 1: First put 315.8g of sucrose powder in the high-efficiency mixing granulator, add 156.6g of 95% medicinal alcohol, start the machine and mix evenly; add 192g of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator Mix with a mixture of sucrose and 95% medicinal alcohol, and at the same time start the machine and granulation cutter to granulate (i.e. make granules), so that all materials are formed and the sucrose containing 95% medicinal alcohol is used as the crystal nucleus to extract medicinal materials outsourced Small particles of dry paste powder; take out the above-mentioned granulated material, and pass through a 18-mesh steel screen through a swing granulator; move the above-mentioned material that has passed through the 18-mesh steel screen into a three-dimensional mixer, and mix 15.7g of the medicine Add talcum powder, 15.7g of medicinal silicon dioxide, and 1.05g of medicinal magnesium stearate in...

Embodiment 2

[0039] Example 2: First put 70.2g of sucrose powder in the high-efficiency mixing granulator, add 34.8g of 70% medicinal alcohol, start the machine and mix evenly; add 437g of medicinal material extraction dry paste powder into the above-mentioned high-efficiency mixing granulator Mix with a mixture of sucrose and 70% medicinal alcohol, and at the same time start the machine and granulating cutter to granulate, so that all materials form small particles of dry cream powder extracted from outsourcing medicinal materials with 70% medicinal alcohol as the crystal nucleus The above-mentioned material through granulation is taken out, and crosses 18 mesh steel sieves by a swinging granulator; the above-mentioned material passed through 18 mesh steel sieves is moved to a three-dimensional mixer, and 15.7g of medicinal talc powder, 15.7g The medicinal silica of 1.05g and the medicinal magnesium stearate of 1.05g are added in the three-dimensional mixer and mixed evenly with the above-...

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PUM

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Abstract

The invention discloses a Keke Tablet, the components of which include dry cream powder extracted from medicinal materials, sucrose powder, medicinal talcum powder, medicinal silicon dioxide, medicinal magnesium stearate and 20-95% medicinal alcohol. Its preparation method is to firstly mix sucrose powder with 20-95% medicinal alcohol evenly, mix evenly with the dry cream powder extracted from medicinal materials, and make small particles with wet sucrose particles as crystal nuclei and dry cream powder extracted from medicinal materials, and then Keke tablets are formed by mixing evenly with medicinal talc powder, medicinal silicon dioxide, magnesium stearate and other raw materials according to a certain weight ratio, and then compressing into tablets. The invention effectively improves the hardness and stability of Keke Tablets, and greatly reduces the failure of film coating and poor stability caused by factors such as insufficient tablet hardness, lobes, loose tablets, and rough surfaces of the preparation during production, transportation, and storage. , unqualified detection, etc., ensure the operability of the Keke tablet of the present invention during production and the performance stability of the product within the validity period, and its preparation process is simple, easy, and low in production cost.

Description

【Technical field】 [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a Keke tablet for treating cough and shortness of breath and a preparation method thereof. 【Background technique】 [0002] Keke Tablets is a Chinese patent medicine with the functions of relieving cough, relieving asthma and eliminating phlegm. It is used for the treatment of cough and shortness of breath. Composition of traditional Chinese medicine. The existing Keke tablet preparation method is to take ephedra and poppy shells and crush them into fine powder, sieve, and keep 45.8% fine powder for later use; add acidic aqueous solution (use 10% hydrochloric acid solution to adjust the pH to about 5) and decoct the remaining coarse powder Second time, add water 10 times for the first time, add water 8 times for the second time, 2 hours each time, filter, adjust the pH value of the filtrate to 7 with 10% sodium hydroxide solution, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/20A61P11/14A61P11/06A61P11/10A61K33/06
Inventor 赖智填唐琳
Owner 中山市恒生药业有限公司