Preparation method and application of Chinese medicine extract for 'prescription for treating diarrhoea with abdominal pain'

A technology of Tongxie essential prescription and extract, which is applied in the field of preparation of drugs for the treatment of irritable bowel syndrome, can solve the problems of no marketing of finished products in the application, difficult storage, difficult dosage forms, etc., and achieve moisture absorption The effect of reducing and reducing the process cost and the method is simple

Active Publication Date: 2009-07-08
SHENZHEN NEPTUNUS PHARM CO LTD
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] "Tongxie Yaofang" is a good prescription for treating irritable bowel syndrome, but its application and development have not been promoted in the market. At present, it is only limited to the decoction of clinicians for the preparation of its extract. Just a decoction, its further application is limited
[0007] The preparation process of the extract of "Tongxie Yaofang", according to the records of the past dynasties, is "Atractylodes macrocephala fried two liang [6g] white peony root fried two liang [6g], orange peel fried one liang five

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] [Example 1] Macroporous Resin Method 1 Preparation of "Tongxie Yaofang Extract"

[0054] Take 50 kg of Chinese herbal medicines fried Atractylodes macrocephala, 50 kg of white peony root, 38 kg of fried tangerine peel, 25 kg of Fangfeng, add 1 ton of 75% ethanol, heat and reflux for extraction for 2 hours, filter, and add 1 ton of 75% ethanol for extraction under reflux 2h, filter, and combine the two extracts. The solvent is recovered under reduced pressure, the temperature is 80°C, concentrated to 9 times the volume of the original medicinal material, the concentrated solution is diluted with 5 times hot water, and an appropriate amount of chitosan, a traditional Chinese medicine clarifying agent, is added, centrifuged, and the precipitate is removed. The supernatant is taken and loaded on D101 macroporous resin column (respectively use acid, alkali, water, alcohol to carry out pretreatment to resin column before sample loading), wash described adsorption with 5BV wat...

Embodiment 2

[0055] [Example 2] Macroporous Resin Method 2 Preparation of "Tongxie Yaofang Extract"

[0056] Take 50 kg of Chinese herbal medicines and stir-fry Atractylodes macrocephala, 50 kg of fried white peony root, 38 kg of fried tangerine peel, 25 kg of Fangfeng, add 1 ton of water, heat and reflux for extraction for 3 hours, filter, add 1 ton of water for reflux and extract for 2 hours, and filter. The two extracts were combined. Recover the solvent under reduced pressure, concentrate to 6 times the volume of the original medicinal material at a temperature of 80°C, dilute the concentrated solution with 3 times hot water, add an appropriate amount of chitosan, a traditional Chinese medicine clarifier, centrifuge, remove the precipitate, take the supernatant, and load the sample on D101 macroporous resin column (pre-treat the resin column with acid, alkali, water, and alcohol before loading the sample), rinse with 2BV of pure water after loading, discard the aqueous solution, and us...

Embodiment 3

[0057] [Example 3] Determination of active ingredients of Tongxie Yaofang extract

[0058] 1. Chromatographic conditions

[0059] High performance liquid chromatography HP1100 series (U.S. Hewlett-Packard Company), using octadecylsilane and silica gel as filler, C18 chromatographic column, specification is 5 μm, 4 × 250mm, column temperature 30 ℃, water (A) and acetonitrile ( B) is mobile phase, gradient elution, ultraviolet detector (UV), detection wavelength 230nm.

[0060] 2. Preparation of samples of Chinese herbal extracts from "Tongxieyao Fang"

[0061] 1) Extract of the present invention

[0062] According to the methods described in Examples 1 and 2 of the present invention, 3 batches of the above-mentioned Chinese medicine extracts were respectively prepared.

[0063] 2) Direct water extract (original method)

[0064] Take 50 kg of Chinese herbal medicines and stir-fry Atractylodes macrocephala, 50 kg of fried white peony root, 38 kg of fried tangerine peel, 25 kg...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method for a Chinese herbal extract 'prescription for treating diarrhoea with abdominal pain', comprising the following steps: (1) fried rhizoma atractylodis macrocephalae, white paeony root, fried dried orange peel and divaricate saposhnikovia root are taken as raw materials, alcohol solution or water is taken as solvent to extract the raw materials to obtain the extracting solution; the weight ratio of the raw materials is as follows: fried rhizoma atractylodis macrocephalae: white paeony root: fried dried orange peel: divaricate saposhnikovia root is equal to 1:1:0.75:0.5; (2) the obtained extracting solution is concentrated until the volume of the extracting solution is 6-9 times of the weight of the raw materials, namely, 1kg of the raw materials corresponds to 6-9L of extracting solution; (3) the concentrated solution obtained in step (2) is diluted by water with 3-5 times of volume and then the supernatant is extracted; (4) the supernatant is absorbed by macroporous resin column, the eluted part of the alcohol is collected to obtain the alcohol eluent; (5) the obtained alcohol eluent is concentrated and dried to prepare the Chinese herbal extract. The invention also relates to the application of the Chinese herbal extract 'prescription for treating diarrhoea with abdominal pain' prepared by the method in preparing the medicines for curing irritable bowel syndrome of intestinal canal.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of a traditional Chinese medicine extract for treating intestinal irritable bowel syndrome. [0002] The present invention also relates to the traditional Chinese medicine extract prepared according to the above preparation method and its application in the preparation of medicine for treating irritable bowel syndrome. Background technique [0003] Irritable bowel syndrome (Irritable bowel syndrome, IBS) is the most common clinical intestinal dysfunction disease, mainly manifested as abdominal pain, bloating, constipation, diarrhea or alternating constipation and diarrhea, is the most common digestive system one of the diseases. The prevalence of IBS in the community population in my country is about 5.7%, the prevalence of IBS in western countries is above 10%, and the global incidence is very high. The incidence is between 1...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/752A61P1/00
Inventor 严启新李勇薛焰高媛李姿陈萍
Owner SHENZHEN NEPTUNUS PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap