Preparation method and application of Chinese medicine extract for 'prescription for treating diarrhoea with abdominal pain'

Abstract

The invention discloses a preparation method for a Chinese herbal extract 'prescription for treating diarrhoea with abdominal pain', comprising the following steps: (1) fried rhizoma atractylodis macrocephalae, white paeony root, fried dried orange peel and divaricate saposhnikovia root are taken as raw materials, alcohol solution or water is taken as solvent to extract the raw materials to obtain the extracting solution; the weight ratio of the raw materials is as follows: fried rhizoma atractylodis macrocephalae: white paeony root: fried dried orange peel: divaricate saposhnikovia root is equal to 1:1:0.75:0.5; (2) the obtained extracting solution is concentrated until the volume of the extracting solution is 6-9 times of the weight of the raw materials, namely, 1kg of the raw materials corresponds to 6-9L of extracting solution; (3) the concentrated solution obtained in step (2) is diluted by water with 3-5 times of volume and then the supernatant is extracted; (4) the supernatant is absorbed by macroporous resin column, the eluted part of the alcohol is collected to obtain the alcohol eluent; (5) the obtained alcohol eluent is concentrated and dried to prepare the Chinese herbal extract. The invention also relates to the application of the Chinese herbal extract 'prescription for treating diarrhoea with abdominal pain' prepared by the method in preparing the medicines for curing irritable bowel syndrome of intestinal canal.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of a traditional Chinese medicine extract for treating intestinal irritable bowel syndrome. [0002] The present invention also relates to the traditional Chinese medicine extract prepared according to the above preparation method and its application in the preparation of medicine for treating irritable bowel syndrome. Background technique [0003] Irritable bowel syndrome (Irritable bowel syndrome, IBS) is the most common clinical intestinal dysfunction disease, mainly manifested as abdominal pain, bloating, constipation, diarrhea or alternating constipation and diarrhea, is the most common digestive system one of the diseases. The prevalence of IBS in the community population in my country is about 5.7%, the prevalence of IBS in western countries is above 10%, and the global incidence is very high. The incidence is between 1...

AI Technical Summary

Problems solved by technology

[0006] "Tongxie Yaofang" is a good prescription for treating irritable bowel syndrome, but its application and development have not been promoted in the market. At present, it is only limited to the decoction of clinicians for the preparation of its extract. Just a decoction, its further application is limited

[0007] The preparation process of the extract of "Tongxie Yaofang", according to the records of the past dynasties, is "Atractylodes macrocephala fried two liang [6g] white peony root fried two liang [6g], orange peel fried one liang five money [4.5g], Two [3g], cut finely, divided into eight servings, decocted in water or taken as pills", the traditional prescription is decocted as the extract, because the extract is decocted in water, it is not easy to store, easy to deteriorate, and has a large fluidity , strong viscosity, if further processed into related preparations, the product has strong moisture absorption and is prone to mold, the main active ingredient contained in it is not high, the volume is large, and it is very difficult to process and prepare new dosage forms