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A method of drying a rapidly dissolving very fine sodium ferric ethylenediamine tetraacetate (nafeedta) product

A technology of sodium ferric ethylenediamine tetraacetate, which is extremely fine, is applied in the direction of drying solid materials, chemical instruments and methods, and drying solid materials without heating, which can solve the problems of slow dissolution and large particle size, and achieve high absorption rate , Improve the yield rate, the effect of strong stability

Active Publication Date: 2011-12-14
BEIJING VITA SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, AkzoNobel abroad has launched a sodium iron ethylenediamine tetraacetate product named Ferrazone, but its product also has the disadvantages of slow dissolution and large particle size.

Method used

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  • A method of drying a rapidly dissolving very fine sodium ferric ethylenediamine tetraacetate (nafeedta) product
  • A method of drying a rapidly dissolving very fine sodium ferric ethylenediamine tetraacetate (nafeedta) product

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Preparation and drying method of rapidly dissolving iron ethylenediaminetetraacetate:

[0023] Take 180kg of ferrous lactate and dissolve it in 500 liters of water, take 240kg of disodium ethylenediaminetetraacetic acid and dissolve it in 1000 liters of water. After mixing the two, adjust the pH value to 5 with sodium bicarbonate and react for 2 hours. In the filter tank, use a vacuum pump to depressurize and filter for solid-liquid separation, concentrate to 400kg, recrystallize 3 times with 80% ethanol, and then transport the NaFeEDTA material to a SZG200 double-cone rotary vacuum dryer heated to 60°C in advance, and vacuum , the vacuum degree is -0.05MPa, start the main motor, and turn the dryer to dry. Adjust the steam control valve at any time during the drying process, control the temperature at 60°C, and dry for 120 minutes; then turn off the steam valve to stop heating, turn off the vacuum valve, stop the vacuum pump, open the negative pressure valve to restore ...

Embodiment 2

[0025] Preparation and drying method of rapidly dissolving iron ethylenediaminetetraacetate:

[0026] Take 110kg of ferrous sulfate and dissolve it in 300 liters of water, take 240kg of disodium ethylenediaminetetraacetic acid and dissolve it in 1000 liters of water. After mixing the two, adjust the pH value to 7 with sodium hydroxide and react for 1 hour. In the filter tank, use a vacuum pump to depressurize and filter for solid-liquid separation, concentrate to 400kg, recrystallize 3 times with 80% ethanol, and then transport the NaFeEDTA material to a SZG200 double-cone rotary vacuum dryer heated to 100°C in advance, and vacuum , the vacuum degree is -0.1MPa, start the main motor, and turn the dryer to dry. Adjust the steam control valve at any time during the drying process, control the temperature at 120°C, and dry for 150 minutes; then turn off the steam valve to stop heating, turn off the vacuum valve, stop the vacuum pump, open the negative pressure valve to restore th...

Embodiment 3

[0028] The preparation method of fast-dissolving ultra-fine ferric edetate:

[0029] Get 160 kg of ferric chloride and dissolve it in 500 liters of water, get 240 kg of ethylenediamine tetraacetic acid disodium salt and dissolve it in 1000 liters of water, after the two are mixed, adjust the pH value to 5 with sodium bicarbonate and sodium hydroxide, react for 0.1 hour, The reaction mixture was passed through a LLW type horizontal screw discharge filter centrifuge with a rotation speed of 4500r / min, centrifuged for 5min, concentrated to 500kg, recrystallized with 80% ethanol for 3 times, and then the NaFeEDTA material was transported to SZG200 preheated to 80°C Double-cone rotary vacuum dryer, vacuumize, the vacuum degree is -0.06MPa, start the main motor, and rotate the dryer to dry. Adjust the steam control valve at any time during the drying process, control the temperature at 110°C, and dry for 110 minutes; then turn off the steam valve to stop heating, turn off the vacuum...

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Abstract

The invention discloses a drying method of fast-dissolving ultrafine ferric sodium ethylenediamine tetraacetate. The method comprises dissolving EDTA sodium salt and iron salt in water, and adjusting The pH value of the reaction liquid is obtained after solid-liquid separation, recrystallization, drying, crushing and sieving, wherein the drying process adopts vacuum drying under reduced pressure. The sodium ferric EDTA obtained by this drying process has the characteristics of rapid dissolution, and the particles of the dried and sieved products are extremely fine, which can all pass through a 120-mesh sieve, and the sieved products do not appear to aggregate into lumps.

Description

technical field [0001] The invention belongs to the technical field of biology and new medicine, and relates to a drying method of very fine sodium iron ethylenediaminetetraacetate (NaFeEDTA) that can be quickly dissolved. Background technique [0002] Sodium ferric ethylenediamine tetraacetate (NaFeEDTA) is an iron nutrition enhancer approved by the Ministry of Health in 1999. Because it is a chelated iron, the absorption rate is 2 to 3 times that of traditional iron nutrition enhancers, and It has good taste, no rust smell and no gastrointestinal irritation, does not affect the sensory and physical and chemical quality of food, is stable in food processing and storage, does not affect the absorption of other minerals and trace elements, and is widely used in soy sauce , fish sauce, cereals and their products, solid beverages and other common food nutritional fortification, but also used in dietary supplements to improve nutritional anemia and promote lead excretion. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/16C07C227/40F26B5/04
Inventor 许中敏刘鲁林
Owner BEIJING VITA SCI TECH
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