Aminoindan derivative or salt thereof

Abstract

Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain. A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2, 3-dihydrdo-1-benzofuran, 2, 3-dihydrdo-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.

Description

technical field

[0001] The present invention relates to aminoindan derivatives or salts thereof useful as medicines, especially NMDA receptor antagonists, and NMDA receptor antagonists containing the aminoindan derivatives or salts thereof as active ingredients. The aminoindane derivative or its salt of the present invention, and the NMDA receptor antagonist with said aminoindane derivative or its salt as active ingredients are effective against Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, Ischemic stroke, pain, etc. have therapeutic or preventive effects. Background technique

[0002] Glutamate functions as a neurotransmitter in the mammalian central nervous system, and it regulates the activity of nerve cells or the release of neurotransmitters through glutamate receptors present in synapses. At present, many pharmacological and physiological studies have shown that glutamate receptors can be divided into ion channel type and metabolic regulation ty...

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