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Use of total saponin extract of fenugreek

A technology of total saponins and fenugreek, applied in the field of application of fenugreek total saponins extract, can solve problems such as reduced exercise tolerance and sexual dysfunction

Active Publication Date: 2011-07-27
GENEHAM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Decreased sexual function and reduced exercise tolerance

Method used

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  • Use of total saponin extract of fenugreek
  • Use of total saponin extract of fenugreek
  • Use of total saponin extract of fenugreek

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 10 kilograms of fenugreek, add 120 kilograms of 50% ethanol, reflux and extract 3 times, each time is 1 hour, centrifuge, combine the centrifugal liquid, and concentrate to obtain the concentrated solution; the concentrated solution is adsorbed on D101 macroporous resin column, washed and discarded , Washed with 0.05% NaOH solution, eluted with 80% ethanol, collected the eluate, concentrated in vacuum to a thick paste, and dried in vacuum to obtain the total fenugreek saponins extract. The saponins content was 35.7% based on diosgenin. This extract was used in Examples 2-5.

[0025] The method of extracting total saponins in this example refers to "Technical Research on Extraction and Purification of Total Saponins from Fenugreek by Macroporous Adsorption Resin"[J]. Research and Information of Chinese Medicine, 2005, 7(6): 19-21.

Embodiment 2

[0027] Acute Toxicity Test of Fenugreek Total Saponins Extract

[0028] 1 Experimental materials

[0029] 1.1 Medicine: Fenugreek total saponin powder, take 15g of this product powder, add water to 100ml, make 1ml suspension containing 0.15g extract, this concentration is the maximum concentration.

[0030] 1.2 Animals: Clean-grade Kunming mice, weighing 18-22g, 60 males, provided by Dongchuang Laboratory Animal Science and Technology Service Department, Kaifu District, Changsha City, Laboratory Animal Production License: SCXK (Hua) 2006-0001; Provided by the animal room of the Hunan Provincial Institute for Drug Control, laboratory animal use license: SYXK (Xiang) 2003-0006. The laboratory temperature is 18~25℃. The animals are reared in separate cages, with 5 animals per cage, fed with standard pellet feed, and freely ingested food and water.

[0031] 2 Experimental methods and results

[0032] 2.1 Pre-test First take 20 mice (male), weighing 18-22g. One-time intragastric administr...

Embodiment 3

[0040] Effect of Fenugreek Total Saponins Extract on Rat Body Weight and Serum Testosterone

[0041] 1 Experimental materials

[0042] Reagent: Fenugreek total saponin powder of the present invention, the powder was dissolved in distilled water during the experiment. Animals: Clean SD rats of Kunming species, provided by Dongchuang Laboratory Animal Science and Technology Service Department, Kaifu District, Changsha City; Laboratory Animal Production License: SCXK (Xiang) 2006-0001; Hunan Provincial Institute of Drug Control Animal Room, Laboratory Animals License: SYXK (Xiang) 2003-0006. Before the experiment, the rats were adaptively fed for 3 days, and the clean SD rats of Kunming species were raised with 5 per cage.

[0043] 2 Experimental methods and results

[0044] 2.1 Drug preparation methods and grouping of experimental animals

[0045] Experimental animals are generally divided into four groups: the first group is the normal control group, given equal volume of distilled wa...

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Abstract

The invention provides application of a common fenugreek seed total saponin extract in preparing a medicine or a health care product for treating or preventing the reduction of the testosterone level and the exercise tolerance. The usage and the dosage of the medicine are determined according to the illness state of patients; the medicine can be taken for 2 to 3 times per day; and the daily dosage per person is between 200 and 4,000 milligrams and preferably between 600 and 1,200 milligrams or is between 0.0036 and 0.0145 gram per kilogram of the body weight. Common fenugreek seed total saponin can improve the testosterone level of blood serum, so that the common fenugreek seed total saponin extract has important function of treating or preventing the reduction of the testosterone level and the exercise tolerance.

Description

Technical field [0001] The invention relates to a new use of a traditional Chinese medicine fenugreek total saponins extract, in particular to the application of a fenugreek total saponins extract in medicines or health products for treating or preventing decreased testosterone levels and decreased exercise tolerance. Background technique [0002] Testosterone is the main component of androgens. It is a C-19 steroid hormone. It is mainly synthesized in the interstitial cells of the testis. In addition to the production and maintenance of male reproductive organs, reproductive function and secondary sexual characteristics, testosterone has been found in recent studies. Low can cause many diseases and impaired exercise tolerance: [0003] The plasma testosterone of male patients with coronary heart disease is significantly lower than that of normal people. Intervention research on coronary heart disease patients with decreased androgen levels also found that long-term intervention t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P5/26A61K36/48A61P43/00A61K131/00
Inventor 谭华
Owner GENEHAM PHARMA CO LTD