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Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof

A wound dressing and chitosan technology, applied in dressings, viscous dressings, medical science and other directions, can solve the problems of inability to keep the wound surface moist, delayed wound healing, heavy dressing change workload, etc., and achieve good biocompatibility, operation Simple, low-cost effects

Inactive Publication Date: 2012-12-05
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages are: unable to keep the wound surface moist, resulting in delayed wound healing, dressing fibers are likely to cause foreign body reactions and affect healing, easy to damage new tissue when changing dressings, pathogens are easy to pass through soaked dressings, and the workload of dressing changes is heavy, etc.
It does have a good application in chest, abdomen, back and other flat parts, but its disadvantages are also obvious. If it hurts the neck, limbs and other areas, the gel solution is easy to slip before curing, which limits the application area.

Method used

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  • Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Dissolving the chitosan powder in 1.5% dilute acetic acid with a mass concentration of 1.5% is prepared into a chitosan slurry with a mass percentage of 3.5%;

[0044] 2. Dissolve PVP powder in deionized water and stir to form a uniform and transparent solution with a mass fraction of 25%;

[0045] 3. Dissolve polyacrylic acid in a deionized aqueous solution with a mass concentration of 27.5% dilute NaOH, and stir to form a 25% mass percent sodium acrylate solution;

[0046] 4. Take 7g of sodium acrylate solution, put 0.01g of potassium persulfate crystals and 0.0164g of N,N-methylenebisacrylamide, then pour 8g of PVP solution and 3.5g of chitosan slurry into it and stir to form a mixed solution;

[0047] 5. Pour the mixed solution into a plastic mold (about 8.5cm×6.5cm in length×width);

[0048] 6. Put it in a vacuum oven, evacuate to remove oxygen, set the temperature at 60°C, and react for 6 hours;

[0049] 7. Take out the hydrogel primary product from the mold,...

Embodiment 2

[0053] 1. Chitosan powder is dissolved in 2% dilute acetic acid with a mass concentration of 2%, and it is prepared into a chitosan slurry with a mass percentage of 3.5%;

[0054] 2. Dissolve PVP powder in deionized water and stir to form a uniform and transparent solution with a mass fraction of 20%;

[0055] 3. Dissolve polyacrylic acid in a deionized aqueous solution with a mass concentration of 27.5% dilute NaOH, and stir to form a sodium polyacrylate solution with a mass percentage of 22%;

[0056] 4. Take 8g of sodium acrylate solution, add 0.01g of ammonium persulfate and 0.01g of polyethylene glycol, then pour 15g of PVP solution and 4g of chitosan slurry into it and stir to form a mixed solution;

[0057] 5. Pour the mixed solution into a plastic mold (about 8.5cm×6.5cm in length×width);

[0058] 6. Put it in a vacuum oven, evacuate to remove oxygen, set the temperature at 50°C, and react for 7 hours;

[0059] 7. Take out the hydrogel primary product from the mold, ...

Embodiment 3

[0063] 1. Dissolving the chitosan powder in 1.5% dilute acetic acid with a mass concentration of 1.5% is prepared into a chitosan slurry with a mass percentage of 3.5%;

[0064] 2. Dissolve PVP powder in deionized water and stir to form a uniform and transparent solution with a mass fraction of 30%;

[0065] 3. Dissolve polyacrylic acid in a deionized aqueous solution with a mass concentration of 27.5% dilute NaOH, and stir to form a sodium polyacrylate solution with a mass percentage of 28%;

[0066] 4. Take 10g of sodium acrylate solution, add 0.01g of benzoyl tert-butyl peroxide and 0.015g of xylitol, then pour 15g of PVP solution and 5g of chitosan slurry into it and stir to form a mixed solution;

[0067] 5. Pour the mixed solution into a plastic mold (about 8.5cm×6.5cm in length×width);

[0068] 6. Put it in a vacuum oven, evacuate to remove oxygen, set the temperature at 45°C, and react for 8 hours;

[0069] 7. Take out the hydrogel primary product from the mold, and ...

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Abstract

The invention relates to a chitosan transparent hydrogel wound dressing for medical use, comprising polyacrylic acid (PAA), polyvinyl ketopyrrolidine (PVP) and chitosan, the weight ratio thereof is 4-20:1.5-15:0.15-3; the wound dressing is transparent flake. The preparation method comprises the following steps: respectively configuring chitosan serum, PVP solution and polyacrylate sodium solution; mixing the 3 solutions and adding evocating agent and cross linking agent to the 3 solutions; pouring the mixture into a mould and obtaining the primary product after reaction at the temperature of 40-75 DEG C; adding preservative to the surface of the primary product and drying the product at the temperature of 40 DEG C; obtaining the wound dressing after cutting, ventilated membrane addition, encapsulation and gamma ray sterilization. The wound dressing can be applied to skin wounds, outside body wounds and tissue engineering. The hydrogel wound dressing of the invention has the characteristics of diminishing inflammation and stanching, and having good hydroscopic property, good conformity and the like, as a result, the wound dressing can partially replace the traditional gauze dressing; the preparation method thereof is simple in operation, low in cost, friendly to the environment and high in economic benefits.

Description

technical field [0001] The invention belongs to the field of medical wound dressing and its preparation and application, in particular to a medical chitosan transparent hydrogel wound dressing and its preparation and application. Background technique [0002] The first human records of wound healing date back thousands of years, when it was discovered that covered wounds healed better than bare wounds. Various types of dressings have appeared for a long time, such as animal fur, honey, plant leaves, and even clay and incense ash are also used as wound coverings. However, gauze dressings called traditional dressings are the most practical, most influential, and have been used for the longest time, and still occupy a large market share. These dressings are generally made from cotton, burlap, and linen. Its advantages are: certain absorbency, simple manufacture, cheap price and reusable. The disadvantages are: the inability to keep the wound moist leads to delayed wound heal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/60A61F13/02A61L15/24
Inventor 杨庆邬莹章悦庭
Owner DONGHUA UNIV
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